Friday, October 7, 2011

The Benefits of Buying Virtually Everything Used

The Benefits of Buying Virtually Everything Used


Alan Powdrill / Getty Images
Alan Powdrill / Getty Images

Most folks understand that buying a new car is — on paper at least — a poor financial decision. Buying a used car generally provides substantial long-term savings. But did you know there’s a growing number of folks who try to buy everything used? Or if not everything, then at least as much as possible.

Take Katy Wolk-Stanley, for instance, who bills herself as The Non-Consumer Advocate. Wolk-Stanley takes her motto from a Depression-era saying: “Use it up, wear it out, make it do, or do without.” On her blog, she’s posted a list of the things she lets herself by new, which basically boils down to underwear and perishables.

(LIST: 12 Things You Should Stop Buying Now)

I had a chance to meet Wolk-Stanley recently, and she proudly gave me a tour of her home, pointing out the used furniture she’s acquired and telling me the story behind each piece. Her dining room chairs, for instance, are from a 1920s Carnegie library and are solid oak with a very classic “craftsman” style.

“I had gone for a walk in my neighborhood and spied a big pile of unwanted stuff on someone’s porch,” Wolk-Stanley said. “That included a grouping of antique chairs. I knocked on the door and asked if they’d sell them to me, which the owner was all too pleased to do. I bought 11 chairs for a grand total of $75. They look perfect in my 1914 Portland bungalow!”

Or there’s Ryan Finlay, who scours Craigslist for good deals. “When I started buying on Craigslist, I had to get past the stigma of buying things used,” Finlay says. “Friends would laugh when they learned that I’d purchased certain items secondhand instead of new. I have much more confidence now, having become very skilled at finding good deals. I usually buy things on average for 10% of the new price.”

Finlay saves big bucks by buying used furniture, appliances, and technology. But more than that, he’s discovered he can make a living buying and selling used stuff on Craigslist. You can read about Finlay’s adventures at ReCraigslist.com.

(MORE: 5 Weird Things People Are Stealing While the Economy’s in Bad Shape)

Even I get in on the act in my own way. My last car was a used Mini Cooper, which may be the best car I’ve ever owned. My next car will also be a used Mini Cooper. And while much of what I buy is new — no question — my wife and I have discovered the frugal siren call of gently used goods. Much of my wardrobe was built from thrift stores or the used gear sales at REI. I buy used books. I buy used tools. I buy refurbished computers.

But maybe the King of Used is my neighbor across the street. John (as we’ll call him) is a retired shop teacher, whom I’ve dubbed the real millionaire next door. Through a passionate devotion to thrift (and some savvy investing), John managed to build wealth on a modest income. After living next door to him for seven years, I’ve come to appreciate his frugal habits: He re-uses kitchen bags, is parsimonious with paper towels, and cuts up old garden hoses for other purposes. Maybe that sounds like a miserable life, but these thrifty habits haven’t cut into his quality of life. Instead, they allow John to spend our winters in New Zealand and our summers on his boat in Alaska.

Buying used isn’t just for weirdos or the working poor. Buying used is for anyone who’d rather pinch pennies on keeping up appearances so they can spend the big bucks on things that matter more.

'Put America back to work' to address deficit, says economist

'Put America back to work' to address deficit, says economist

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The US economy added 103,000 jobs in September, ahead of many economists' expectations.

But the jobless rate was stuck at 9.1%, according to latest data from the Department of Labor.

Professor Joseph Stiglitz won the Nobel Prize in Economics in 2001, and is a professor at Columbia Business School. He told the BBC that the figures did not reflect the dire situation within the US jobs market.

Source

Go to source to watch video.

Millions stroll in New York's 'park in the sky'

Millions stroll in New York's 'park in the sky'

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One of the runaway hits of this past summer in New York has not been on Broadway - instead it has been at a most unusual park which is attracting millions of visitors from all around the world.

The disused elevated railway track that runs through downtown Manhattan now offers commuters and tourists alike a peaceful escape from the chaos on the busy city streets below.

The inside story of New York City's so-called "park in the sky'' is about to be told in a book called High Line.

Michael Maher took a stroll through the park to find out more.

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Go to the source to watch the amazing video about "The High Line" :)

Thursday, October 6, 2011

Steve Jobs: 'Death is life's best invention' - DO what you love to do - Keep looking, DON'T SETTLE!!

Steve Jobs: 'Death is life's best invention'










Steve Jobs, the co-founder of Apple, who died on Wednesday after a long battle with cancer, was an inspiring speaker.

In 2005 he made speech to Stanford University in which he said his mortality was what helped him to make the big choices in his life.

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Wednesday, October 5, 2011

Michael Moore Tonight at #OccupyWallStreet: "This Is a Historic Day" (Day 19, 10/5/11)

Michael Moore Tonight at #OccupyWallStreet: "This Is a Historic Day" (Day 19, 10/5/11)



Michael's courage is hope for us all. He is our economic hero. He wants a fair society based on fair regulations, fair trade, and happiness for as many as possible.



What a disgrace to all officers and all our courageous heroes that risk their lives for the safety of their fellow citizen.

The Pancreatic Cancer That Killed Steve Jobs

The Pancreatic Cancer That Killed Steve Jobs

Getty Images

In their announcement of founder Steve Jobs' death, at age 56, Apple officials did not mention a specific cause of death. But the visionary digital leader had been battling pancreatic cancer since 2004.

Pancreatic cancer is one of the faster spreading cancers; only about 4% of patients can expect to survive five years after their diagnosis. Each year, about 44,000 new cases are diagnosed in the U.S., and 37,000 people die of the disease.

The pancreas contains two types of glands: exocrine glands that produce enzymes that break down fats and proteins, and endocrine glands that make hormones like insulin that regulate sugar in the blood. Jobs died of tumors originating in the endocrine glands, which are among the rarer forms of pancreatic cancer.

IN MEMORIAM: Technology's Great Reinventor: Steve Jobs (1955-2011)

In 2004, Jobs underwent surgery to remove the cancer from his pancreas. In 2009, after taking another leave of absence from Apple, Jobs had a liver transplant in an effort to retain as much of his organ function as possible after his cancer had spread beyond the pancreas. In January, he took a third leave from the company before resigning as CEO in August.

"I have always said if there ever came a day when I could no longer meet my duties and expectations as Apple's CEO, I would be the first to let you know," Jobs wrote in a letter to the Apple board of directors on August 24. "Unfortunately, that day has come."

According to experts, Jobs' was an uphill medical battle. "He not only had cancer, he was battling the immune suppression after the liver transplant," Dr. Timothy Donahue of the UCLA Center for Pancreatic Disease in Los Angeles, who had not treated Jobs, told MSNBC.com. He noted that most patients who receive liver transplants survive about two years after the surgery.

Standard treatments for pancreatic cancer include the common tumor-fighting strategies — surgery, chemotherapy, radiation and, most recently, targeted anticancer drugs that may slightly extend patients' lives. In 2005, the Food and Drug Administration approved erlotinib, a drug that specifically targets growth factors found on cancer cells, for the treatment of patients with advanced pancreatic cancer who are receiving chemotherapy. The drug has been shown in trials to improve overall survival by 23% after a year when added to routine chemotherapy. The tumors in patients being treated with erlotinib and chemo also develop more slowly than those in patients receiving chemotherapy alone.

PHOTOS: The Long, Extraordinary Career of Steve Jobs

Because of the poor prognosis of pancreatic cancer, however, many patients elect to try alternative therapies, including a popular therapy known as the Gonzalez regimen, which involves fighting pancreatic tumors with pancreatic enzymes. Patients on the Gonzalez regimen also take a large number of nutritional supplements, including vitamins and minerals such as magnesium citrate, along with coffee enemas performed twice a day.

The treatment's developer, Dr. Nicholas Gonzalez of New York, has claimed that the use of pancreatic enzymes is a powerful way to suppress the growth of advanced pancreatic cancer cells. But a study published in the Journal of Clinical Oncology in 2009, which compared groups of patients on the Gonzalez regiment to patients on standard chemotherapy treatment, found that those on chemo survived for a median of 14 months while those on the alternative therapy survived for a median of only 4.3 months.

Jobs is not reported to have tried the Gonzalez regimen, but he is known to have suscribed to alternative therapy. In a 2008 story, Fortune reported that Jobs initially tried to treat his tumor with diet instead of surgery, soon after he was diagnosed in 2004. In January, Fortune reported that he had also made a hush-hush trip to Switzerland in 2009 for a radiation-based hormone treatment. The exact details aren't clear, but the University Hospital of Basel in Switzerland is known for its special form of treatment for neuroendocrine cancer, which is not available in the U.S.

Whether these treatments helped to extend Jobs' life or improve the quality of his last days isn't clear. But cancer experts expressed surprise that Jobs survived as long as he did, continuing to fight his disease. Other pancreatic cancer patients typically aren't as fortunate. Another high-profile patient, actor Patrick Swayze, managed to live for 20 months after his diagnosis, taking advantage of chemotherapy treatments. But, overall, patients' median survival is generally only five months.

VIDEO: Steve Jobs' Career at Apple (in Two Minutes)

Jobs lost his battle with cancer at a time when researchers are constantly pushing the boundaries of treatments, particularly with antitumor agents that can home in on abnormally growing cells with increasing precision. In the end, his cancer proved too advanced to rein in with even the most innovative technologies.

"Apple has lost a visionary and creative genius, and the world has lost an amazing human being," Tim Cook, Jobs' successor at Apple, wrote to employees on Wednesday. "Steve leaves behind a company that only he could have built, and his spirit will forever be the foundation of Apple."

Alice Park is a writer at TIME. Find her on Twitter at @aliceparkny. You can also continue the discussion on TIME's Facebook page and on Twitter at @TIME.

Nobel winner Ralph Steinman's quest to cure cancer - including his own

Nobel winner Ralph Steinman's quest to cure cancer - including his own

Ralph Steinman

Ralph Steinman died days before it was announced that he was to share the Nobel Prize for Medicine. His work had been part of an unorthodox experiment to save his life, writes journalist Brett Norman.

When Ralph Steinman learned he had pancreatic cancer, the dogged immunologist put his life's work to the test.

He launched a life-and-death experiment in the most personal of personalised medicine.

By unlucky coincidence, he had been diagnosed with pancreatic cancer, a disease that might benefit from the therapies he had spent his life researching.

Usually, medical research proceeds at a glacial, thorough pace: cell studies lead to studies in small animals which lead to studies in larger animals, which eventually lead to small, highly-selective clinical trials in humans. But Steinman didn't have that kind of time.

He did, however, have access to world class facilities, cutting-edge technology, and some of the world's most brilliant medical minds, thanks to his position as a researcher at Rockefeller University.

So Steinman decided to make his own body the ultimate experiment.

He had removed a piece of the tumour that would eventually kill him, and trained his immune cells to track down any hint of the tumour that might have escaped the surgery, like putting hounds on a scent.

Start Quote

The made-for-Hollywood story of the renegade scientist who fights the establishment to prove his discovery, and then uses it to cure himself, was powerful enough to compel hope.”

On Friday, four-and-a-half years after he was diagnosed with a disease that kills the vast majority of its victims in less than one, that experiment came to an end.

Steinman died at the end of a week in which he continued his work in the lab. It was a testament to the undying optimism of the scientific enterprise, to the unrelenting man, and to the limits of both.

An open secret

I joined Rockefeller as a science writer to chronicle the work of its researchers - Steinman included - about halfway through one of his experiments on himself.

His experiment was an open secret on campus, registered with the hospital and aided by a long-time friend and staff physician. The sense of hope was palpable, bound up in respect for the man but also something broader.

Dendritic Cells

Dendritic cell
  • Dendritic cells are a special class of cells similar to monocytes
  • They live in the blood and lymph tissues, and in the lungs and intestines
  • They've recently been discovered in the heart and brain of mice
  • One dendritic-cell based vaccine - Provenge - is available now for advanced prostate cancer. It has not been a huge success, but it has led the way to commercialisation for drug makers
  • Other vaccines are under development

Could the painstakingly incremental research that seemed to have so much potential on lab animals this once grant a reprieve from certain death?

Of course everyone was rooting for him, and I had a special interest. Toward the end of 1999, my father had a stomach complaint. Over a few months, the initial diagnosis of an ulcer morphed into a death sentence: inoperable, metastatic cancer of the pancreas.

Pancreatic cancer is often known as the "silent killer" because it doesn't often produce truly scary symptoms until it has spread beyond repair. After chemotherapy, my dad bounced back for a few months, but the cancer inevitably did, too. He died at home in the early fall of 2000.

Could Steinman beat it?

I hoped so. The work had promise.

'Sceptical' science

In 1973, along with his mentor, Zanvil Cohn, Steinman published the discovery of a new class of cell in the immune system - the dendritic cell. Like many new discoveries, his faced a deeply sceptical reception.

The experiments couldn't be immediately reproduced, but Steinman was convinced of his discovery. He fought for a decade before immunologists began to broadly recognise the central importance of those cells to their field.

In the past 20 years, the study of dendritic cells has spread to hundreds of labs all over the world. Researchers are exploring how they might be harnessed to fight cancer, HIV and transplant rejection, among other major medical problems.

Dendritic cells are the "sentinel cells" of the mammalian immune system. Named after the Greek word for tree, they develop distinctive probing branches when activated, sweeping their environment in search of unwelcome things - like bacteria, viruses, tumours.

When dendritic cells encounter something they don't like, they take a physical marker of the invader, called an antigen, and present it to B and T cells, the defenders of the body' s immune system. Those cells then adapt weapons to identify and destroy the interlopers.

Steinman bet that if he could train his dendritic cells to recognise and tag his cancer, they would be able to convince the T and B cells to do the rest.

Dream deferred

There was no good reason to expect that Steinman could fashion a cure for one of the world's most vicious cancers in time to save his own life. But it was easy to think it was at least possible. The made-for-Hollywood story of the renegade scientist who fights the establishment to prove his discovery, and then uses it to cure himself, was powerful enough to compel hope.

Unfortunately, the dendritic cell-based treatments didn't work - at least not well enough.

Training Steinman's dendritic cells to the tumour did generate a "vigorous immune response to mesothelin, a tumour specific antigen," said Dr. Sarah Schlesigner, a longtime colleague of Steinman's who ran the trial.

In other words, while there were significant side effects, the therapy seemed to enable him to work much longer than he otherwise would have. Month after month, he remained at the University, continuing his work.

He survived much longer than expected, and continued his research until the end.

Over time, it wasn't enough.

At least, not enough to save him.

But the research he pioneered continues - and the scientists who continue his work have an extraordinary example to follow.

Brett Norman is a health care reporter for POLITICO Pro

Source

Steve Jobs - His Life and Obituary

Steve Jobs

Steve Jobs
He combined technical innovation with cool design

Despite his wealth and corporate success, Steve Jobs always managed to retain the air of a Silicon Valley buccaneer.

His abrasive style meant he was often difficult to work with but his eye for a desirable product made Apple one of the planet's most recognised brands.

Steven Paul Jobs was born in San Francisco on 24 Feb 1955, the son of two unmarried university students, Joanne Schieble and Syrian born Abdulfattah Jandali.

His parents gave him up for adoption and he was taken in by a working class Californian couple Paul & Clara Jobs.

Months after his adoption, his biological parents married and had a daughter, Mona, who did not learn of her brother's existence until she was an adult.

He was brought up in his adoptive parent's home in Silicon Valley, the hub of the US electronics industry.

LSD

While attending a local high school the young Jobs was offered a summer job at the Hewlett Packard plant in Palo Alto where he found himself working alongside a fellow student named Steve Wozniak.

He dropped out of college after one term and went to work for the video game manufacturer Atari with the idea of raising enough money to travel to India.

Apple 1 computer
The Apple 1 kick started the PC revolution

Jobs returned from his trek around the sub continent with a shaven head, wearing Indian robes and having experienced the effects of LSD; he was to remain a Buddhist and vegetarian throughout his life.

He went back to work at Atari and joined a local computer club with his friend Steve Wozniak who was designing and building his own computer.

In 1976 Jobs pre-sold 50 of Wozniak's machines to a local computer store and, armed with a copy of the order, successfully persuaded an electronics distributor to let him have the components on credit.

He managed to launch the machine, called the Apple 1, without having borrowed any money or given up a share of the business to anyone else.

Ousted from Apple

He named the company after his favourite fruit which, either by chance or design ensured it appeared in phone book listings ahead of rival Atari.

The profit from the first Apple was ploughed back into an improved version, the Apple II, which appeared at a Californian computer fair in 1977.

Development of the new machine was expensive and Jobs persuaded Mike Markkula, a local investor, to guarantee a $250,000 loan and, together with Wozniak, the three formed the company Apple Computer.

The Apple II, unlike many other computers of the time, came complete and worked straight out of the box rather than the purchaser having to assemble the various parts.

The new model became an instant success, kick starting the personal computer boom, achieving sales in excess of six million before production ended in 1993.

Wozniak & Jobs
Budding entrepreneurs Steve Wozniak (l) and Steve Jobs

But there were concerns at Apple about Jobs' lack of management experience and professional executives were hired to run the company.

One Apple board member claimed Jobs was "uncontrollable." "He got ideas in his head, and being a founder of the company, he went off and did them regardless of whether it ended up being good for the company."

Jobs introduced the Macintosh in 1984 to wild acclaim, but behind the hyped up launch there were financial problems at Apple.

A downturn in sales, and a growing resentment at what many employees saw as Jobs' autocratic style, resulted in an internal power struggle and he was ousted from the company.

Toy Story

By this time he had other irons in the fire. He founded NeXT Computer in 1985 and a year later bought Graphics Group from the Star Wars director, George Lucas.

The company, which Jobs renamed Pixar, produced extremely expensive computer animation hardware which was used by a number of film makers, including Disney.

Jobs switched the emphasis away from computer manufacturing and began producing computer animated feature films.

The breakthrough came in 1995 with the film Toy Story, which went on to gross more than $350 million worldwide, and was followed by other successes including A Bug's Life, Finding Nemo and Monsters Inc.

Steve Jobs
Ever the showman at new product launches

A year later, Apple paid more than $400 million for NeXT computer and Jobs was back with the company he founded, wasting no time in removing Apple's then, Chief Executive Officer.

Jobs tackled Apple's poor profitability by dropping some fringe projects and moving the company into the burgeoning consumer electronics market.

The iPod, launched in 2001 satisfied the demand for music on the move and immediately became a style icon with its sleek design and distinctive white ear phones.

To drive his new machine Jobs also launched iTunes, allowing customers to download music from the internet and create their own play lists.

iphone

In 2003 Jobs was diagnosed with pancreatic cancer and, rejecting the idea of surgery, set about finding alternative therapy, including a special diet.

He finally underwent surgery in 2004 having kept his illness secret from all but a small handful of Apple insiders.

Steve Jobs
The launch of the iphone

In 2005 Disney paid $7 billion worth of stock to buy Pixar from Jobs who, as a result, became the Walt Disney Company's biggest shareholder.

Two years later, at yet another much hyped launch, Jobs introduced the iPhone to a legion of customers, many of whom had queued for hours at their local Apple store.

In 2008 the ultra thin Macbook Air was launched with Jobs doing his usual stage presentation dressed in his habitual black turtle neck jumper and faded jeans.

His thin and somewhat gaunt appearance fuelled speculation that his illness had returned and it was announced, in early 2009, that he was taking a six month break to cope with what was described as a "hormonal imbalance."

In April of that year he underwent a liver transplant, with his doctors announcing that the prognosis was "excellent."

However, in Jan 2011, Apple announced that Jobs would taking a leave of absence for health reasons.

Unlike his contemporary, Microsoft's Bill Gates, Steve Jobs showed little inclination to use his personal wealth for philanthropic purposes.

And, strangely for a self-professed Buddhist, he did not embrace environmental concerns, with Apple coming under fire from Greenpeace for its reluctance to produce easily recyclable products.

Steve Jobs was a one off; a man who had total belief in his own abilities and a shortage of patience for anyone who failed to agree with him.

His great gifts were an ability to second guess the market and an eye for well designed and innovative products that everyone would buy.

"You can't just ask customers what they want and then try to give that to them," he once said. "By the time you get it built, they'll want something new."

Source

L.A. Noire developer shuts down for good

L.A. Noire developer shuts down for good


After months of rumors, L.A. Noire developer Team Bondi is officially out of business.

It has been a tumultuous year for Team Bondi, filled with some very high highs, and some very low lows. After nearly seven years spent in development, this May the results of years of work was finally released, and L.A. Noire was an immediate hit. Using facial animation technology in a new way, Team Bondi created a game that took existing gaming styles of gameplay and turned them on their head. L.A. Noire has sold close to two million copies worldwide, and both the game and the developer were applauded. Then the criticisms began.

It began when problems between Team Bondi and publisher Rockstar came to light. Rockstar had considered incorporating Team Bondi into its family and rebranding them as Rockstar Sydney, but then tensions between Team Bondi founder Brendan McNamara and Rockstar execs flared, and the publisher publicly refused to continue working with the developer. Fair or not, McNamara received the bulk of the blame for the deteriorating relationship, and that impression was further fueled by several current and former Team Bondi employees coming forth and claiming that the working conditions violated several legal and ethical rules. Over 100 developers were said to be excluded from the final credits as well.

There were defenders of Team Bondi, but the damage had already been done, and the loss of Rockstar as a partner became an insurmountable obstacle. Rumors of bankruptcy began to fly, and then a last minute save from George Miller’s KMM Studios seemed to be in the works.

Those negotiations ended up going nowhere, and now Gamasutra is reporting that papers filed with the Australian Securities and Investment Commission reveal that Team Bondi is in the process of fully shutting down.

L.A. Noire was originally planned as the first game in a potential franchise, utilizing the motion capture technology. The question now becomes, what happens to the property? Even without Team Bondi, the possible series-in-them-making has the potential to remain a lucrative one, and Take Two–Rockstar’s parent company and IP holder–isn’t likely to let a successful series die along with its developer.

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How foreign doctors save lives in rural America

How foreign doctors save lives in rural America

Dr Afram and Dr Salem talk about their experiences in rural West Virginia

Many rural areas in the US suffer from a shortage of doctors. Unable to attract Americans, they have turned to foreign-born physicians.

The city of Logan in West Virginia has just 1,779 citizens. The nearest large city, Charleston, is an hour away, via winding roads through the Appalachian mountains. Logan is surrounded by rural land, and is in an area which has lost half its population since the 1950s.

It's a far cry from just about anything that would attract an affluent doctor from overseas. And yet they come.

Dr Salem
Dr Salem is the only gastroenterologist in the area

Just 232 doctors per 100,000 residents work in the state of West Virginia. One neighbouring state has more than 400.

The US Department of Health designates 51 out of 55 counties in the state as "medically under-served areas". Logan County is among them, and that is precisely why doctors from all parts of the world fill the hallways of Logan Regional Medical Center.

Path to green card

A visa waiver programme was set up in 1994 to address the shortage by offering foreign-born doctors on J-1 student visas an easy path to a permanent residency - if they agree to work in an under-served area for three years.

Foreign-born doctors in the US

  • India: 40,000
  • Philippines: 12,800
  • China: 9,600
  • Canada: 8,200
  • North and South Korea: 7,900
  • Pakistan: 7,900

Source: American Community Survey, 2009

"I would never even have considered West Virginia when I was training back in New Jersey," says Dr Ziad Salem, who has been working in Logan for more than five years.

Born in Beirut, Dr Salem grew up in Paris and went to medical school in Los Angeles. A job in a rural area was the only chance to stay in the US, but Logan was not his only option.

Hospitals and state agencies have to compete to get the best foreign-born doctors to their part of the country.

Logan Regional recruits them through its corporate office in Tennessee, and by using professional recruiters scouring hospital residency programmes nationwide.

The specialist areas that most of the foreign-born physicians were trained in makes them an invaluable asset to hospital and community alike.

Map of West Virginia
Logan County lies in the southern part of West Virginia

"We have a pulmonologist on a J-1 because we didn't find an American. That is life-saving treatment right there," says John Walker, CEO of Logan Regional.

Each state is allowed to fill 30 slots every year under the visa waiver programme. West Virginia was able to fill 19 of them in 2011.

"We try to speak to them and let them know that the state is beautiful and great to raise a family. It's economically safe and has a low crime rate," says Monique Witten Mahone, J-1 visa waiver co-ordinator for the Division of Rural Health and Recruitment.

Rare species

It's a marketing campaign to a highly skilled and needed workforce that might have never heard about the area and feels slightly out of place.

Start Quote

Abraham Verghese

Many of my patients were very grateful that I didn't look like a hometown boy.”

Abraham Verghese Former physician in Tenessee

"When I first decided to go to West Virginia there was a little bit of an anxiety," says Dr David Afram, who was born in Syria and did his residency in Washington, DC.

"I mean this is not New York, New Jersey, or Detroit. It's probably not an area that is used to foreign-born people or accents and even minorities like African-Americans or Hispanics are extremely rare in the state."

Only 1.3% of the population in West Virginia is foreign-born, one of the US's lowest levels, but a third of its doctors was born abroad, according to Census data. People have grown accustomed to hearing foreign accents in the doctor's office.

"This area... needed a gastroenterologist. [People] actually respect the fact that we are here," says Salem.

When Dr Abraham Verghese worked in rural Tennessee in the 1980s caring for Aids patients, he found that his foreign looks were a welcome sight in a small community where everyone knew each other.

"Many of my patients were very grateful that I didn't look like a hometown boy and that I had no reason to judge them," says Dr Verghese.

Potential abuse
Logan, West Virginia
The median household income in Logan County was $34,596 (£22,060) according to Census 2010 data

The physicians' visa very much depends on them staying employed at the hospital that sponsored them from the start, which in some instances has resulted in abuse.

Dr Salem and Dr Afram say they feel very appreciated at Logan Regional, but each know of colleagues in other states that did not get the same treatment.

"It was very obvious," says Dr Afram of his friends' experiences. "You are here because you have to be here, because you have nowhere to go. In terms of the hours, in terms of the respect, in terms of the call schedule - it was sort of like a slave labour."

But word-of-mouth reputation is important for Logan's hospital to satisfy the never-ending demand for more doctors.

Both doctors received their green card recently and with it the freedom to leave Logan and practise anywhere in the US.

"You see the huge need and what you would have to leave behind if you actually left here," says Dr Salem.

"I finished my waiver requirement, I even got my green card recently, and I still have signed a contract for another two years because I grew accustomed to the people and to the place. I'm still here."

Source

Nobel win for crystal discovery

Nobel win for crystal discovery

Shechtman (Credit: Nobelprize.org)
"There can be no such creature," Dr Shechtman initially said

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The Nobel prize for chemistry has gone to a single researcher for his discovery of the structure of quasicrystals.

The new structural form was previously thought to be impossible and provoked controversy.

Daniel Shechtman, from Technion - Israel Institute of Technology in Haifa, will receive the entire 10m Swedish krona (£940,000) prize.

The Nobel prize in chemistry caps this year's science awards.

Professor David Phillips, president of the Royal Society of Chemistry, called quasicrystals "quite beautiful".

He added: "Quasicrystals are a fascinating aspect of chemical and material science - crystals that break all the rules of being a crystal at all."

Dr Shechtman had to fight a fierce battle against established science to convince others of what he had first seen in his lab at the National Institute of Standards and Technology in Washington - formerly called the National Bureau of Standards - on an April morning in 1982.

For years, the researcher was "ridiculed" and "treated badly" by his peers, he recounts.

The Nobel laureate first created quasicrystals by rapidly cooling molten metals, such as aluminium and manganese, by squirting the mixture onto a cool surface.

By sending an electron wave through a molten metal "grate", the Israeli researcher was able to see how the wave was diffracted by the metals' atoms.

Under the microscope he observed that the new crystal was made up of perfectly ordered, but never repeating, units - a structure that is at odds with all other crystals that are regular and precisely repeating.

Dr Shechtman himself is said to have cried "Eyn chaya kazo", which translates from the Hebrew as "there can be no such creature".

Against the grain

"The head of my lab came to me smiling sheepishly, and put a book on my desk and said: 'Danny, why don't you read this and see that it is impossible what you are saying,'" Dr Shechtman recounted in an interview with Technion.

The Israeli researcher was later told that he was a disgrace to the group and asked to leave.

On returning to Israel, Dr Shechtman published the results.

"Then all hell broke loose," he said.

Many scientists from around the world started telling him that they too had seen the same crystal structure.

Not everyone was convinced, however. To his dying day, Linus Pauling, the head of the American Chemical Society, said that Dr Shechtman was "talking nonsense".

But Bassam Shakhashiri, president-elect of the American Chemical Society, told BBC News: "This is how we make progress in science.

"[If] someone comes up with a discovery that we are sceptical about…we [have to] take time to verify the observations and discuss the conclusions among ourselves."

He added: "This is a really great example of the triumph of science.

"And an opportunity for all of us... who are curious about nature, to be vigilant, to be careful, and to engage in respectful debate about the interpretation of results."

'Quite beautiful'

Irregular shapes, similar to what Dr Shechtman was seeing, are found in the medieval Islamic mosaics of the Alhambra Palace in Spain. The tiles that line the walls and floors of the palace are regular, and follow mathematical rules, but also never repeat themselves.

Following Dr Shechtman's discovery, scientists have formed other kinds of quasicrystals in the lab, and a naturally forming example has been found among mineral samples from a Russian river.

Quasicrystal (Credit: SPL)
The "forbidden symmetry" of the quasicrystal was first spied in 1982

Quasicrystal structures tend to be hard, non-sticky and are poor conductors of heat and electricity. These properties make them useful as coatings for frying pans and as insulating material for electrical wires.

They are also found in the world's most durable steel, used in razor blades and ultra-fine needles in eye surgery.

"It's a great work of discovery, with potential applications that range from light-emitting diodes to improved diesel engines," said the president of the American Chemical Society, Nancy Jackson.

Dr Andrew Goodwin, from the department of chemistry at Oxford University, added: "Shechtman's quasicrystals are now widely used to improve the mechanical properties of engineering materials and are the basis of an entirely new branch of structural science.

"If there is one particular lesson we are taking from his research, it is not to underestimate the imagination of nature herself."

The Nobel prizes have been given out annually since 1901, covering the fields of medicine, physics, chemistry, literature and peace.

Monday's award of the 2011 prize for physiology or medicine went to Bruce Beutler of the US, Jules Hoffmann from France and Ralph Steinman from Canada for their work on immunology.

And Tuesday's award for physics went to Saul Perlmutter and Adam Riess of the US and Brian Schmidt of Australia, who will divide the prize for their discovery that our Universe's expansion is accelerating.

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Commentary

Science is becoming more and more close minded.

Newer discovers are taking longer and longer to accept and more proof is being asked than should rationally be acceptable.

This story should lessen the ego of scientists and allow them to think more creatively and with more of an open mind.

Apple co-founder Steve Jobs dies aged 56

Apple co-founder Steve Jobs dies aged 56

Steve Jobs
Steve Jobs had battled pancreatic cancer for years

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Former chief executive and co-founder of US technology giant Apple Steve Jobs has died, the company says. He was 56.

"Steve's brilliance, passion and energy were the source of countless innovations that enrich and improve all of our lives. The world is immeasurably better because of Steve," Apple said.

Jobs announced he was suffering from pancreatic cancer in 2004.

He was one of the world's best-known business leaders and introduced the iPod and the iPhone to the world.

His death came a day after Apple unveiled its latest iPhone 4S model.

More than almost any other business leader, Jobs was indistinguishable from the company he co-founded in the 1970s.

As the face of Apple, he represented its dedication to high-end technology and fashionable design.

And inside the company he exerted a level of influence unheard of in most businesses.

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Monday, October 3, 2011

Vast shark sanctuary created in Pacific

Vast shark sanctuary created in Pacific


Environment correspondent, BBC News
"Sharks now banned" underwater photoshoot
The Marshall Islands initiative is the latest in a worldwide islands' movement to protect sharks

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The Marshall Islands government has created the world's largest shark sanctuary, covering nearly two million sq km (750,000 sq miles) of ocean.

The Pacific republic will ban trade in shark products and commercial shark fishing throughout its waters.

Tourism, including diving, is a staple of the Marshall Islands archipelago, which is home to just 68,000 people.

Sharks and their near relatives such as rays are seriously threatened by issues such as habitat loss and fishing.

Start Quote

The momentum for protecting these animals continues to spread across the globe”

Matt Rand Pew Environment Group

About a third of ocean-going sharks are on the internationally-recognised Red List of Threatened Species.

"In passing this [shark protection] bill, there is no greater statement we can make about the importance of sharks to our culture, environment and economy," said Senator Tony deBrum, who co-sponsored the bill through the Marshallese parliament.

"Ours may be a small island nation, but our waters are now the biggest place sharks are protected."

To put the sanctuary in context, it covers roughly the same area as Indonesia, Mexico or Saudi Arabia, and is about eight times bigger than the UK.

The move will extend the area of ocean in which sharks are protected from about 2.7 million sq km to 4.6 million sq km (1.0 to 1.8 million sq miles).

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Under the bill, commercial shark fishing and any trade in shark products will be banned, and any of the fish accidentally caught must be released alive.


Whale shark
The sanctuary will swallow a huge chunk of the Pacific Ocean


Certain designs of fishing gear will be banned from Marshallese waters; and violators of all these measures face fines of up to £200,000.

The Marshallese government has worked on the plan with advisors from the Pew Environment Group, the US-based organisation that identified archipelago nations as providing big marine conservation "wins" because of the vast scale of their territorial waters.

"We salute the Republic of the Marshall Islands for enacting the strongest legislation to protect sharks that we have seen," said Matt Rand, Pew's director of global shark conservation.

"As leaders recognise the importance of healthy shark populations to our oceans, the momentum for protecting these animals continues to spread across the globe."

The Marshall Islands follows the lead taken by Palau two years ago, whose sanctuary was then the world's biggest. Other nations including the Bahamas have since followed suit.

Last week, a group of eight countries including Mexico, Honduras, the Maldives and Northern Mariana Islands signed a declaration announcing they would push for more shark protection across the world.

Because they grow and reproduce relatively slowly, sharks are especially vulnerable to factors such as accidental or targeted fishing.

Shark protection measures are also likely to help marine biodiversity overall, as they restrict the rights of fishing vessels and require greater scrutiny of landings.

However, with the Marshall Islands as with Palau and some other countries, there are questions over the capacity of authorities to monitor fully such huge expanses of ocean.

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Commentary

For anyone unsure of the benefit of sharks and why we should protect them, I'll give small rundown as to why this sanctuary is beneficial.

Sharks limit other animals from eating away natural resources too quickly. The herbivores that sharks feed on eat the producers. The only protection producers have are the sharks that, as carnivores eating herbivores, keep the other animals in check and stop them from destroying the natural ecosystem, keeping the environment sustainable.

Think of a shark as a diet on a group of herbivores. That diet keeps the environment fit and healthy and sustains it, rather than allowing all the herbivores to destroy their environment and eat all the natural resources around them.

Sharks are very beneficial in this way and are crucial to the harmony of the ecosystems of our world. The majority of them also do not eat humans and are not aggressive towards humans.

Hundreds freed after New York Wall Street protest

Hundreds freed after New York Wall Street protest

Protester Michael Pellagatti, New York, 2 October
Protester Michael Pellagatti holds up the plastic handcuffs used to restrain him and the court summons he was issued

Police in New York City have freed most of the more than 700 people arrested on Brooklyn Bridge on Saturday during a protest against corporate greed.

Fewer than 20 protesters are still held as they are yet to be identified.

Most of those freed were given citations for disorderly conduct and a criminal court summons.

The Occupy Wall Street group, camped in Manhattan's financial district for two weeks, says it will continue its demonstrations.

A spokesman for the New York Police Department told the BBC the small group still detained were expected to appear at the Manhattan criminal court on Sunday.

'Multiple warnings'

The arrests took place on Saturday after protesters carried out an impromptu walk over the East River to Brooklyn.

Some demonstrators carried slogans reading "End the Fed" and "Pepper spray Goldman Sachs".

Police said the protesters were given "multiple warnings" to keep to the pedestrian walkway but spread to the road, halting bridge traffic for several hours.

Some protesters accused the police of not issuing warnings or of tricking them on to the roadway, accusations the police denied.

Demonstrator Henry-James Ferry: "'The police moved in with orange mesh barricade". Saturday footage courtesy Robert Cammiso

Occupy Wall Street says it will continue its campaign, with meetings on Sunday in Zuccotti Park, the privately owned area of land not far from Wall Street that it has occupied since 17 September.

There will be another march on Wall Street on Wednesday afternoon.

"We are the majority. We are the 99%. And we will no longer be silent," the group said in a statement.

"We are using the revolutionary Arab Spring tactic to achieve our ends and encourage the use of non-violence to maximise the safety of all participants."

The protesters have had previous run-ins with New York's police.

On Friday, about 2,000 people marched under the Occupy Wall Street banner to New York's police headquarters to protest against arrests and police behaviour.

Some 80 people were arrested during a march on 25 September, mostly for disorderly conduct and blocking traffic, but one person was charged with assaulting a police officer.

A series of other small-scale protests have also sprung up in other US cities in sympathy with the aims of Occupy Wall Street.

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What damage does alcohol do to our bodies?

What damage does alcohol do to our bodies?

Alcoholic drinks

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We know that drinking too much alcohol is bad for us. It gives us hangovers, makes us feel tired and does little for our appearance - and that is just the morning afterwards.

Long term, it increases the risk of developing a long list of health conditions including breast cancer, oral cancers, heart disease, strokes and cirrhosis of the liver.

Research shows that a high alcohol intake can also damage our mental health, impair memory skills and reduce fertility.

The direct link between alcohol and the liver is well understood - but what about the impact of alcohol on other organs?

Numerous heart studies suggest that moderate alcohol consumption helps protect against heart disease by raising good cholesterol and stopping the formation of blood clots in the arteries.

Toxic

However, drinking more than three drinks a day has been found to have a direct and damaging effect on the heart. Heavy drinking, particularly over time, can lead to high blood pressure, alcoholic cardiomyopathy, congestive heart failure and stroke. Heavy drinking also puts more fat into the circulation of the body.

The link between alcohol and cancer is well established, says Cancer Research UK. A study published in the BMJ this year estimated that alcohol consumption causes at least 13,000 cancer cases in the UK each year - about 9,000 cases in men and 4,000 in women.

Cancer experts say that for every additional 10g per day of alcohol drunk, the risk of breast cancer increases by approximately 7-12%.

High alcohol intake - the surprises

  • Digestive problems
  • Spotty, bloated face
  • Cellulite
  • Disrupted sleep
  • Depression
  • Short-term memory failure
  • Reduced fertility

For bowel cancer, previous studies show that increasing alcohol intake by 100g per week increases the cancer risk by 19%.

A recent report in BioMed Central's Immunology journal found that alcohol impairs the body's ability to fight off viral infections.

And studies on fertility suggest that even light drinking can make women less likely to conceive while heavy drinking in men can lower sperm quality and quantity.

Why alcohol has this negative effect on all elements of our health could be down to acetaldehyde - the product alcohol is broken down into in the body.

Acetaldehyde is toxic and has been shown to damage DNA.

Dr KJ Patel, from the Medical Research Council's laboratory of molecular biology in Cambridge, recently completed a study into the toxic effects of alcohol on mice.

His research implies that a single binge-drinking dose of alcohol during pregnancy may be sufficient to cause permanent damage to a baby's genome.

Foetal alcohol syndrome, he says, "can give rise to children who are seriously damaged, born with head and facial abnormalities and mental disabilities".

'Clear dose relationship'

Alcohol is a well-established cancer causing agent, he says.

"You cannot get a cancer cell occurring unless DNA is altered. When you drink, the acetaldehyde is corrupting the DNA of life and puts you on the road to cancer.

"One of most common genetic defects in man is our inability to counteract the toxicity of alcohol."

Dr Nick Sheron, who runs the liver unit at Southampton General Hospital, says the mechanisms by which alcohol does damage are not quite so clear cut.

Alcohol intake - the major health risks

Drinking about three drinks per day:

  • Cancers of the oral cavity and pharynx, oesophagus, larynx, breast, liver, colon, rectum
  • Liver cirrhosis
  • Essential hypertension
  • Chronic pancreatitis

"The toxicity of alcohol is complex, but we do know there is a clear dose relationship."

With alcoholic liver disease, the greater the alcohol intake per week the greater the liver damage and that increases exponentially for someone drinking six to eight bottles or more of wine in that period, for example.

Over the past 20 to 30 years, Dr Sheron says, deaths from liver disease have increased by 500%, with 85% of those due to alcohol. Only in the last few years has that rise slowed down.

"Alcohol has a bigger impact than smoking on our health because alcohol kills at a younger age. The average age of death for someone with alcoholic liver disease is their 40s."

'More harmful than heroin or crack'

Alcohol is undoubtedly a public health issue too.

Earlier this year, NHS figures showed that alcohol-related hospital admissions has reached record levels in 2010. Over a million people were admitted in 2009-10, compared with 945,500 in 2008-09 and 510,800 in 2002-03. Nearly two in three of those cases were men.

At the same time the charity Alcohol Concern predicted the number of admissions would reach 1.5m a year by 2015 and cost the NHS £3.7bn a year.

Last year, a study in The Lancet concluded that alcohol is more harmful than heroin or crack when the overall dangers to the individual and society are considered.

The study by the Independent Scientific Committee on Drugs also ranked alcohol as three times more harmful than cocaine or tobacco because it is so widely used.

So how much alcohol is too much? What can we safely drink?

Glasses of wine Did you know? There are 16g of alcohol in a 175ml glass of red or white wine.

The government guidelines on drinking are being reviewed at present. They currently say that a women should not drink more than two to three units of alcohol per day and a man three to four units a day.

But Paul Wallace, a GP and chief medical adviser of Drinkaware, says people are just not aware of the alcohol content of a large glass of wine.

"Most of us don't realise what we're drinking and you can very easily slip beyond acceptable limits."

Katherine Brown, head of research at the Institute of Alcohol Studies, says the current guidelines and how they are communicated may be giving the public misleading information.

"We need to be very careful when suggesting there is a 'safe' level of drinking for the population. Rather, we need to explain that there are risks associated with alcohol consumption, and that the less you drink the lower your risk is of developing health problems.

"We hope the government use this as an opportunity to help change perceptions about regular drinking being a normal, risk-free practice."

Dr Wallace wants the government to do a better job on the message it sends out by explaining the alcohol guidelines in units per week, rather than per day - no more than 21 units for men, 14 units for women per week.

Dr Sheron agrees: "There is no such thing as a safe level, but the government has got to draw a line somewhere. It's a balance.

"People like having a drink, but they have to accept there's a risk-benefit ratio."

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