Thursday, March 8, 2012

Touch-and-go tablet and computer screens

Touch-and-go tablet and computer screens

(Copyright: Getty Images)

(Copyright: Getty Images)

The new iPad launched yesterday amid its usual fanfare. But could dwindling supplies of a crucial component make such events a thing of the past?

Another iPad launch, another event filled with intense anticipation and speculation. This time Apple’s CEO Tim Cook revealed that the latest iteration of iPad will feature a high-definition screen, and no doubt its competitors will rapidly follow suit.

But there is a problem looming on the horizon for fans of the latest tablet computers, not to mention smart phones and flatscreen TVs. Whether it is on the shiny new iPad, computer or phone, the chances are that you are reading this article through a screen laced with one of the rarest metals on Earth: indium. And analysts are warning that global supplies of indium could be exhausted as soon as 2017. So how will we live without the gadgets that we have come to depend on?

Such a prospect might not seem as alarming as running out of essential commodities, such as food or water. But over the past few decades digital displays have become so enmeshed in our lives that they are integral to our social interactions and livelihoods from rural East Africa to the offices of Wall Street. I have met Kenyan fisherwomen trading their wares via SMS to clients based hundreds of kilometres away – an opportunity that depends on indium just as much as my need to read these words I am typing on my computer monitor.

Wonder metal

Though it was discovered 150 years ago, indium’s remarkable qualities have been harnessed only recently to create wafer-thin electrodes. It is a very soft silvery metal that can be painted onto glass because unlike other soft metals, such as mercury, it wets the glass rather than forming beads. (Another curious property of indium is that when you bend a rod of the metal, it issues a high-pitched crackling sound, known as its “cry”.)

Indium is most useful, however, when it is manufactured into indium tin oxide, or ITO. The reason you cannot see it is because when indium reacts with oxygen, it becomes transparent. This, plus its tremendous ability to conduct electricity, allows our mobile phones to be smarter, our TV flatscreens to be larger and our tablet computers to be more sleek.

As a result, the price of indium has rocketed in recent years – it went from $60 per kilogramme in 2003 to $1,000 in just three years – giving rise to a whole new indium smuggling industry, primarily out of China. And there is no let up on our demand for hi-tech displays – there were more than 1.5 billion mobile phone handsets alone sold in 2011, one of which was to me.

But the supply of indium cannot meet our voracious demands. Indium is harvested as a byproduct of zinc mining because this so-called "hitchhiker" metal exists almost entirely in trace amounts inside deposits of other ores such as zinc and lead – sometimes as little as 1 part per million. And because indium is not mined in its own right, greater demand for it won't necessarily lead to more being mined, according to Robert Ayres, a physicist and economist at INSEAD business school in France. "Most of the indium is just single atoms stuck inside rock that can never be utilised," he says.

If the most gloomy predictions for indium are true, Ayres says the only solution is to increase recycling efforts. Because of its value, the indium recycling market is already bigger than primary production.

But a single monitor screen typically contains less than 0.5 g of ITO, so recovering such a tiny amount from electronic products is expensive and energy-intensive. "I call indium a “spice metal”, because it's sprinkled into products in a way that makes it almost impossible to recover," says Armin Reller, a materials physicist at the University of Augsburg in Germany.

So what other options do we have to indium? Finding a material that is transparent, light and conducts electricity as efficiently as ITO is a big challenge, but there are some candidates. So-called non-stochiometric tin oxides, which use the far more abundant aluminium, are one option that could be incorporated fairly easily into current manufacturing set-ups. The problem is that they do not perform as well as ITO and that tin is itself running out, with reserves estimated to last another 20-40 years.

Researchers in Germany and Japan are working on a flexible polymer-based material called PEDOT, which when doped with various chemicals becomes more transparent and a better conductor. Again, the polymer relies on non-renewable oil or coal supplies.

What’s desperately needed is a sustainable alternative, and the best solution could come in the shape of a remarkable material called graphene, the subject of a recent Nobel Prize. Like pencil-lead and diamonds, graphene is yet another form of carbon, one of the most abundant elements on Earth. Graphene's carbon atoms are arranged in a flat sheet of hexagons, like chicken wire, and this structure makes it the strongest known material and can conduct electricity as well as copper. And because graphene is just one atom thick, it is almost transparent.

Graphene may be one of the most versatile materials ever discovered – with an endless list of possibilities ranging from miniaturised computer chips to high-capacity batteries (and believe it or not for making extra-strong vodka). But one of its most-desired applications is to roll it up into carbon nanotubes and use it in touchscreens, as it offers several advantages over ITO. Graphene is more stable, so it will survive better in applications where the product will be subjected to constant physical force, such as regular finger-pounding. And graphene's superior flexibility means that it can be shaped in various configurations – you could create a spherical touchscreen, for example.

So why have we not already moved from ITO to carbon? Mark Hersam, a carbon nanotubes pioneer at Northwestern University in Illinois, believes we're waiting for an industry tipping point. "There's tremendous inertia in the electronics sector because the entire industry is modelled around ITO. Big companies like Apple are wedded to the ITO manufacturing processes and will need to invest substantially to start using carbon," he says. However, as the price of indium goes up and it becomes harder to get hold of, there is likely to be a switch."

With solar cells and electronics all competing for the same rare metal, industry is already under increasing pressure to start using a different material, whether that's another metal oxide or novel carbon chicken-wire. Looking through the breathless coverage of the iPad 3 launch on my phone, one thing is for sure: our unwavering enthusiasm for touchscreen/display-screen technologies means we desperately need to find alternatives soon.

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Which jobs have more women than men?

Which jobs have more women than men?

Commuters

Most journalists are women. Most authors are women. Most teachers, lab technicians, therapists, editors, librarians, public relations officers and insurance underwriters are women.

In fact, it is arguable that women now hold a greater proportion of Britain's professional jobs than their representation in the workforce would lead one to expect.

The statistics team in the House of Commons library has just published data on women in public life, the professions and the board room. On International Women's Day it is worth celebrating the progress there has been over the past decade in trying to achieve equality for women in the workplace.

In some parts of public and corporate life there is still some way to go. Just 22% of MPs and peers are women, with a similar proportion in the Cabinet and serving as judges in the courts. As of last month, just 15% of FTSE 100 company directors were women.

But what does equality look like? As I scrutinised the tables of occupations and the ratio of male to female employees, I began to wonder if only 50:50 really represented job done.

A look at official employment stats reveals that the number of men working full-time is 13.58m compared to 7.68m women. The figures for part-time working show 2.01m men and 5.86m women. If we assume that two part-time jobs equals one full-time job, it means that 58% of the workforce are men and 42% are women.

So, it could be argued that equal gender representation within the current employment market would see roughly four out of 10 jobs in any sector held by women.

With this in mind, one sees that among the professions, some 44% of jobs are filled by women - slightly higher than their representation within the workforce might lead one to expect.

Women now make up 45% of the country's GPs, with the same figure in a category comprising solicitors, lawyers, judges and coroners. It is a similar story with scientists - 46% are women.

The employment consequences of the government's austerity package are expected to have a greater impact on women than men, particularly those working part-time in the public sector. There are still glass ceilings for women in some parts of the country's professional and public life.

But on International Women's Day, perhaps it is also worth reflecting on how much has been achieved already.


Table showing Women in the professions, 2001 - 2010

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Stem cells beat kidney rejection

Stem cells beat kidney rejection

Operating theatre
The study involved eight patients

Related Stories

An injection of stem cells given alongside a kidney transplant could remove the need for a lifetime of drugs to suppress the immune system, say scientists.

Early tests of the technique at US hospitals were successful in a small number of patients.

The journal Science Translational Medicine reports how the majority no longer need anti-rejection medication.

Researchers said it could have a "major impact" on transplant science.

One of the key problems associated with organ transplantation is the risk that the body will "recognise" the new organ as a foreign invader and attack it.

To prevent this, patients take powerful drugs to suppress their immune systems, and will have to do this for life.

The drugs come at a price, preventing organ rejection but increasing the risk of high blood pressure, diabetes and serious infection.

Challenges

The study, carried out at the University of Louisville and the Northwestern Memorial Hospital in Chicago, involved eight patients.

Their transplant came from a live donor, who also underwent a procedure to draw stem cells, the building blocks of their immune system, from the blood.

The transplant recipient's body was prepared using radiotherapy and chemotherapy to suppress their own immune system.

Then the transplant went ahead, with the stem cells put into their body a couple of days later.

“Start Quote

It's almost surreal when I think about it because I feel so healthy and normal”

Lindsay Porter

The idea is that these will help generate a modified immune system that no longer attacks the organ or its new owner.

Although the patients started off with the same anti-rejection drugs, the aim was to reduce these slowly, hopefully withdrawing them completely over time.

Five out of the eight patients involved in the trial managed to do this within a year.

One of those is 47-year-old Lindsay Porter, from Chicago.

She said: "I hear about the challenges recipients have to face with their medications and it is significant.

"It's almost surreal when I think about it because I feel so healthy and normal."

Dr Joseph Leventhal, associate professor of surgery at Northwestern University Feinberg School of Medicine, said: "The preliminary results from this ongoing study are exciting and may have a major impact on organ transplantation in the future."

He said that, as well as kidney patients, the technique might improve the lives of those receiving other organs.

While stem cells from organ donors have been used before, this is the first time it has been used for "mismatched" transplants, in which donors and recipients do not have to be related and immunologically similar.

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Can three minutes of exercise a week help make you fit?

Can three minutes of exercise a week help make you fit?

Michael Mosley on exercise bike

A few relatively short bursts of intense exercise, amounting to only a few minutes a week, can deliver many of the health and fitness benefits of hours of conventional exercise, according to new research, says Dr Michael Mosley. But how much benefit you get from either may well depend on your genes.

When I first read studies which suggested that I could make significant and measurable changes to my fitness by doing just three minutes of exercise a week, I was incredulous.

But this apparently outrageous claim is supported by many years of research done in a number of different countries including the UK, so I decided to give it a go.

“Start Quote

Aerobic fitness is a measure of how good your heart and lungs are at getting oxygen into your body and is an excellent predictor of future health”

My guide into the world of High Intensity Training (HIT), was Jamie Timmons, professor of ageing biology at Birmingham University.

Jamie assured me that by doing just three minutes of HIT a week for four weeks, I could expect to see significant changes in a number of important health indices.

The first, and the one I was most interested in, is insulin sensitivity. Insulin removes sugar from the blood, it controls fat and when it becomes ineffective you become diabetic.

My father was a diabetic and died from complications of that disease. Jamie assured me that research from a number of centres has shown that three minutes of HIT a week improves insulin sensitivity by an average of 24%.

The second improvement I was likely to see would be in my aerobic fitness. Aerobic fitness is a measure of how good your heart and lungs are at getting oxygen into your body and is an excellent predictor of future health. I asked Jamie why.

"The simple answer is we don't know," he replied. "What we do know is that it is a very, very powerful predictor of future health."

Genetic test

So if I could improve my insulin sensitivity and my aerobic fitness then that should improve my general health. But Jamie said there was a potential sting in the tail. There was a possibility that I wouldn't improve. Not because HIT doesn't work but because I've inherited the wrong genes.

FIND OUT MORE

Michael Mosley
  • Michael Mosley presents Horizon: The Truth About Exercise on BBC Two at 21:00 GMT on Tuesday 28 February 2012 or watch online via iplayer (UK only) afterwards at the above link

The fact is that people respond to exercise in very different ways. In one international study 1,000 people were asked to exercise four hours a week for 20 weeks. Their aerobic fitness was measured before and after starting this regime and the results were striking.

Although 15% of people made huge strides (so-called "super-responders"), 20% showed no real improvement at all ("non-responders").

There is no suggestion that the non-responders weren't exercising properly, it was simply that the exercise they were doing was not making them any aerobically fitter.

Jamie and his collaborators investigated the reasons for these variations and discovered that much of the difference could be traced to a small number of genes.

On the basis of this finding they have developed a genetic test to predict who is likely to be a responder, and who is not. Jamie offered me that test. But I would not be told the results until I had completed my HIT regime.

I agreed, had blood taken and went through some baseline tests to assess my starting point, fitness-wise. Then I began to do HIT.

Full throttle

It's actually very simple. You get on an exercise bike, warm up by doing gentle cycling for a couple of minutes, then go flat out for 20 seconds.

A couple of minutes to catch your breath, then another 20 seconds at full throttle. Another couple of minutes gentle cycling, then a final 20 seconds going hell for leather. And that's it.

Michael Mosley tries high intensity training

So how does it work? According to Jamie, and other researchers I spoke to, part of the explanation is (probably) that HIT uses far more of our muscle tissue than classic aerobic exercise.

When you do HIT, you are using not just the leg muscles, but also the upper body including arms and shoulders, so that 80% of the body's muscle cells are activated, compared to 20-40% for walking or moderate intensity jogging or cycling.

Active exercise also seems to be needed to break down the body's stores of glucose, deposited in your muscles as a substance called glycogen. Smash up these glycogen stores and you create room for more glucose to be sucked out of the blood and stored.

Somewhat sceptical I went off and dutifully did my four weeks of HIT, making a grand total of 12 minutes of intense exercise and 36 minutes of gentle pedalling. I then went back to the lab to be retested.

HEALTH AND EXERCISE

The results were mixed. My insulin sensitivity had improved by a remarkable 24%, which was extremely satisfying, but my aerobic fitness had not improved at all.

I was crestfallen, but Jamie was not surprised. It turns out that the genetic test they had done on me had suggested I was a non-responder and however much exercise I had done, and of whatever form, my aerobic fitness would not have improved. My dreams of winning Olympic gold ended there and then.

I will continue doing HIT because I can see the benefits. It won't suit everyone, because although it is short, it is extremely intense. Like any new exercise regime if you have a pre-existing medical condition you should consult your doctor before trying it.

Michael Mosley presents Horizon: The Truth About Exercise is on BBC Two at 21:00 GMT on Tuesday 28 February 2012 or watch online afterwards at the above link.

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Nicolas Sarkozy says France has too many foreigners

Nicolas Sarkozy says France has too many foreigners

Nicolas Sarkozy at his interview on French television [6 March 2012] Nicolas Sarkozy says the system for integrating immigrants is at risk of breaking down

French President Nicolas Sarkozy has said there are too many foreigners in France and the system for integrating them is "working worse and worse".

In a TV debate, Mr Sarkozy defended his plan to almost halve the number of new arrivals if re-elected next month.

Mr Sarkozy is trailing in the opinion polls behind the Socialist candidate Francois Hollande.

He is also competing for conservative voters with the far-right National Front party led by Marine le Pen.

The president said while immigration could be a boon for France, it needed to be controlled more tightly through tougher qualification rules for residency.

Mr Sarkozy, whose father was a Hungarian immigrant, also said he wanted to restrict some benefit payments to immigrants who had been in the country for 10 years.

Tough new rules

He has often made controversial comments on race and immigration issues, sharply dividing opinion in France.

In 2005, just before the Paris riots, he described young delinquents in the Paris suburbs as "racaille", meaning rabble.

He has said that if re-elected, he will reduce the number of immigrants to France from 180,000 a year to 100,000 and introduce tighter controls on access to welfare benefits.

As president, Mr Sarkozy has already pushed through tough new immigration rules, including the controversial deportation of Roma gypsies.

On Tuesday, Prime Minister Francois Fillon caused dismay among Muslim and Jewish groups by suggesting the religious slaughter of animals was out of date.

The controversy started when a TV documentary said last month that all the abattoirs in Paris region only produced halal meat.

So far the election campaign seems to have made relatively little impact on voters.

The latest opinion poll published on Tuesday by CSA showed the Socialist leader Francois Hollande widening his lead over President Sarkozy for the 22 April vote.

It also suggested that the Socialist leader would win decisively by 54% to 46% in a second round of voting on 6 May.

Source

~~~~~~~~~~~~

Commentary

"Give me your tired, your poor/Your huddled masses yearning to breathe free"

What happened to those human values and why have they been replaced with xenophobia?

What happened to looking at a human for who they are, not by their culture or their skin color?

What happened to human dignity and preciousness?

Sarkozy has flushed it all down his french toilet. His people would do well to get rid of his racist french hiney.

The myth of the eight-hour sleep

The myth of the eight-hour sleep

Woman awake

We often worry about lying awake in the middle of the night - but it could be good for you. A growing body of evidence from both science and history suggests that the eight-hour sleep may be unnatural.

In the early 1990s, psychiatrist Thomas Wehr conducted an experiment in which a group of people were plunged into darkness for 14 hours every day for a month.

It took some time for their sleep to regulate but by the fourth week the subjects had settled into a very distinct sleeping pattern. They slept first for four hours, then woke for one or two hours before falling into a second four-hour sleep.

Though sleep scientists were impressed by the study, among the general public the idea that we must sleep for eight consecutive hours persists.

In 2001, historian Roger Ekirch of Virginia Tech published a seminal paper, drawn from 16 years of research, revealing a wealth of historical evidence that humans used to sleep in two distinct chunks.

His book At Day's Close: Night in Times Past, published four years later, unearths more than 500 references to a segmented sleeping pattern - in diaries, court records, medical books and literature, from Homer's Odyssey to an anthropological account of modern tribes in Nigeria.

A woman tending to her husband in the middle of the night by Jan Saenredam, 1595 Roger Ekirch says this 1595 engraving by Jan Saenredam is evidence of activity at night

Much like the experience of Wehr's subjects, these references describe a first sleep which began about two hours after dusk, followed by waking period of one or two hours and then a second sleep.

"It's not just the number of references - it is the way they refer to it, as if it was common knowledge," Ekirch says.

During this waking period people were quite active. They often got up, went to the toilet or smoked tobacco and some even visited neighbours. Most people stayed in bed, read, wrote and often prayed. Countless prayer manuals from the late 15th Century offered special prayers for the hours in between sleeps.

And these hours weren't entirely solitary - people often chatted to bed-fellows or had sex.

A doctor's manual from 16th Century France even advised couples that the best time to conceive was not at the end of a long day's labour but "after the first sleep", when "they have more enjoyment" and "do it better".

Ekirch found that references to the first and second sleep started to disappear during the late 17th Century. This started among the urban upper classes in northern Europe and over the course of the next 200 years filtered down to the rest of Western society.

By the 1920s the idea of a first and second sleep had receded entirely from our social consciousness.

When segmented sleep was the norm

  • "He knew this, even in the horror with which he started from his first sleep, and threw up the window to dispel it by the presence of some object, beyond the room, which had not been, as it were, the witness of his dream." Charles Dickens, Barnaby Rudge (1840)
  • "Don Quixote followed nature, and being satisfied with his first sleep, did not solicit more. As for Sancho, he never wanted a second, for the first lasted him from night to morning." Miguel Cervantes, Don Quixote (1615)
  • "And at the wakening of your first sleepe You shall have a hott drinke made, And at the wakening of your next sleepe Your sorrowes will have a slake." Early English ballad, Old Robin of Portingale
  • The Tiv tribe in Nigeria employ the terms "first sleep" and "second sleep" to refer to specific periods of the night

Source: Roger Ekirch

He attributes the initial shift to improvements in street lighting, domestic lighting and a surge in coffee houses - which were sometimes open all night. As the night became a place for legitimate activity and as that activity increased, the length of time people could dedicate to rest dwindled.

In his new book, Evening's Empire, historian Craig Koslofsky puts forward an account of how this happened.

"Associations with night before the 17th Century were not good," he says. The night was a place populated by people of disrepute - criminals, prostitutes and drunks.

"Even the wealthy, who could afford candlelight, had better things to spend their money on. There was no prestige or social value associated with staying up all night."

That changed in the wake of the Reformation and the counter-Reformation. Protestants and Catholics became accustomed to holding secret services at night, during periods of persecution. If earlier the night had belonged to reprobates, now respectable people became accustomed to exploiting the hours of darkness.

This trend migrated to the social sphere too, but only for those who could afford to live by candlelight. With the advent of street lighting, however, socialising at night began to filter down through the classes.

In 1667, Paris became the first city in the world to light its streets, using wax candles in glass lamps. It was followed by Lille in the same year and Amsterdam two years later, where a much more efficient oil-powered lamp was developed.

London didn't join their ranks until 1684 but by the end of the century, more than 50 of Europe's major towns and cities were lit at night.

Night became fashionable and spending hours lying in bed was considered a waste of time.

Street-lighting in Leipzig in 1702 A small city like Leipzig in central Germany employed 100 men to tend to 700 lamps

"People were becoming increasingly time-conscious and sensitive to efficiency, certainly before the 19th Century," says Roger Ekirch. "But the industrial revolution intensified that attitude by leaps and bounds."

Strong evidence of this shifting attitude is contained in a medical journal from 1829 which urged parents to force their children out of a pattern of first and second sleep.

"If no disease or accident there intervene, they will need no further repose than that obtained in their first sleep, which custom will have caused to terminate by itself just at the usual hour.

"And then, if they turn upon their ear to take a second nap, they will be taught to look upon it as an intemperance not at all redounding to their credit."

Today, most people seem to have adapted quite well to the eight-hour sleep, but Ekirch believes many sleeping problems may have roots in the human body's natural preference for segmented sleep as well as the ubiquity of artificial light.

This could be the root of a condition called sleep maintenance insomnia, where people wake during the night and have trouble getting back to sleep, he suggests.

The condition first appears in literature at the end of the 19th Century, at the same time as accounts of segmented sleep disappear.

"For most of evolution we slept a certain way," says sleep psychologist Gregg Jacobs. "Waking up during the night is part of normal human physiology."

The idea that we must sleep in a consolidated block could be damaging, he says, if it makes people who wake up at night anxious, as this anxiety can itself prohibit sleeps and is likely to seep into waking life too.

Stages of sleep

Every 60-100 minutes we go through a cycle of four stages of sleep

  • Stage 1 is a drowsy, relaxed state between being awake and sleeping - breathing slows, muscles relax, heart rate drops
  • Stage 2 is slightly deeper sleep - you may feel awake and this means that, on many nights, you may be asleep and not know it
  • Stage 3 and Stage 4, or Deep Sleep - it is very hard to wake up from Deep Sleep because this is when there is the lowest amount of activity in your body
  • After Deep Sleep, we go back to Stage 2 for a few minutes, and then enter Dream Sleep - also called REM (rapid eye movement) sleep - which, as its name suggests, is when you dream

In a full sleep cycle, a person goes through all the stages of sleep from one to four, then back down through stages three and two, before entering dream sleep

Source: Gregg Jacobs

Russell Foster, a professor of circadian [body clock] neuroscience at Oxford, shares this point of view.

"Many people wake up at night and panic," he says. "I tell them that what they are experiencing is a throwback to the bi-modal sleep pattern."

But the majority of doctors still fail to acknowledge that a consolidated eight-hour sleep may be unnatural.

"Over 30% of the medical problems that doctors are faced with stem directly or indirectly from sleep. But sleep has been ignored in medical training and there are very few centres where sleep is studied," he says.

Jacobs suggests that the waking period between sleeps, when people were forced into periods of rest and relaxation, could have played an important part in the human capacity to regulate stress naturally.

In many historic accounts, Ekirch found that people used the time to meditate on their dreams.

"Today we spend less time doing those things," says Dr Jacobs. "It's not a coincidence that, in modern life, the number of people who report anxiety, stress, depression, alcoholism and drug abuse has gone up."

So the next time you wake up in the middle of the night, think of your pre-industrial ancestors and relax. Lying awake could be good for you.

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DNA analysis shows huge genetic diversity in tumours

DNA analysis shows huge genetic diversity in tumours

Kidney Cancer cells
Kidney cancer cells

Related Stories

Taking a sample from one part of a tumour may not reveal its full genetic identity, according to research by scientists from Cancer Research UK (CRUK).

They carried out the first genome-wide analysis of the genetic variation between different regions of the same tumour using samples of kidney cancer.

They found around two third of genetic faults were not repeated across other biopsies from the same tumour. The research was published in the New England Journal of Medicine.

Lead author Professor Charles Swanton, based at CRUK's London Research Institute and the UCL Cancer Institute said:

"This has revealed an extraordinary amount of diversity, with more differences between biopsies from the same tumour at the genetic level than there are similarities. The next step will be to understand what's driving this diversity in different cancers and identify key driver mutations that are common throughout all parts of a tumour."

The tumour samples were donated by patients with advanced kidney cancer being treated at London's Royal Marsden Hospital.

The findings may explain why personalised cancer treatments based on biomarkers from tumour biopsies are not always successful.

The gene sequencing revealed that even samples next to each other in the tumour were not identical.

Professor Swanton said as a clinician the findings did not surprise him but they helped explain why cancers are so difficult to treat once they have spread.

He said cancers adapted as they grew, along 'Darwinian principles' of evolution: "We need to think of tumours like trees, with common mutations in the trunk but the more they spread into the branches the greater the genetic diversity."

Prof Swanton said the findings underlined the importance of early diagnosis of cancer before it had spread, and the need to target the common mutations in the 'trunk' of the cancer.

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Oetzi the Iceman's nuclear genome gives new insights

Oetzi the Iceman's nuclear genome gives new insights

Sampling the body of Oetzi (Samadelli Marco/EURAC)
"The Iceman" has been the subject of constant study for more than 20 years

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New clues have emerged in what could be described as the world's oldest murder case: that of Oetzi the "Iceman", whose 5,300-year-old body was discovered frozen in the Italian Alps in 1991.

Oetzi's full genome has now been reported in Nature Communications.

It reveals that he had brown eyes, "O" blood type, was lactose intolerant, and was predisposed to heart disease.

They also show him to be the first documented case of infection by a Lyme disease bacterium.

Analysis of series of anomalies in the Iceman's DNA also revealed him to be more closely related to modern inhabitants of Corsica and Sardinia than to populations in the Alps, where he was unearthed.

'Really exciting'

The study reveals the fuller genetic picture as laid out in the nuclei of Oetzi's cells.

This nuclear DNA is both rarer and typically less well-preserved than the DNA within mitochondria, the cell's "power plants", which also contain DNA.

Oetzi reconstruction (South Tyrol Museum of Archaeology/EURAC/Marco Samadelli-Gregor Staschitz) A reconstruction shows what Oetzi may have looked like before an arrow felled him

Oetzi's mitochondrial DNA had already revealed some hints of his origins when it was fully sequenced in 2008.

Albert Zink, from the Eurac Institute for Mummies and the Iceman in Bolzano, Italy, said the nuclear DNA study was a great leap forward in one of the most widely studied specimens in science.

"We've been studying the Iceman for 20 years. We know so many things about him - where he lived, how he died - but very little was known about his genetics, the genetic information he was carrying around," he told BBC News.

He was carrying around a "haplotype" that showed his ancestors most likely migrated from the Middle East as the practice of formal agriculture became more widespread.

It is probably this period of transition to an agrarian society that explains Oetzi's lactose intolerance.

Prof Zink said that next-generation "whole-genome" sequencing techniques made the analysis possible.

"Whole-genome sequencing allows you to sequence the whole DNA out of one sample; that wasn't possible before in the same way.

"This was really exciting and I think it's just the start for a longer study on this level. We still would like to learn more from this data - we've only just started to analyse it."

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The Raspberry Pi computer goes on general sale

The Raspberry Pi computer goes on general sale

Dr Eben Upton of the Raspberry Pi Foundation shows Rory Cellan-Jones how the computer works

Related Stories

A credit-card sized computer designed to help teach children to code has gone on sale for the first time.

The Raspberry Pi is a bare-bones, low-cost computer created by volunteers mostly drawn from academia and the UK tech industry.

Sold uncased without keyboard or monitor, the Pi has drawn interest from educators and enthusiasts.

Supporters hope the machines could help reverse a lack of programming skills in the UK.

"It has been six years in the making; the number of things that had to go right for this to happen is enormous. I couldn't be more pleased," said Eben Upton of the Raspberry Pi Foundation which is based in Cambridge.

“Start Quote

That's eight weeks pocket money for me”

Peter Boughton, 12, from Cambridgeshire

Massive demand for the computer has caused the website of one supplier, Leeds-based Premier Farnell, to crash under the weight of heavy traffic.

School tools

The device's launch comes as the Department for Education considers changes to the teaching of computing in schools, with the aim of placing greater emphasis on skills like programming.

In a speech outlining those changes, Michael Gove mentioned the Pi, suggesting devices like it could play an important role in the kind of computer class the government envisages.

"Initiatives like the Raspberry Pi scheme will give children the opportunity to learn the fundamentals of programming," he said.

"This is a great example of the cutting edge of education technology happening right here in the UK."

Initially the £22 ($35) model of the Pi will be offered for sale. A cheaper £16 ($25) version will go on sale later in the year.

The machine, which runs on open-source operating system Linux, can be hooked up to a typical computer monitor - with additional ports used to attach a keyboard, mouse and other peripherals.

It also features an ethernet port, meaning the device can make use of high-speed internet connectivity.

Supporters hope the thousands-strong community of people that has grown up around the Pi will help develop additional software and suggest uses for the device.

The Pi going on general sale is likely to add to the buzz around the machine, but there are already a number of similar stripped-down computers on the market.

These include devices such as the Beagleboard and the Omnima MiniEMBWiFi.

Bottle-necks banished

The Raspberry Pi Foundation says it has already produced thousands of the machines, using a Chinese manufacturer.

“Start Quote

The real task, however, is not about getting the Raspberry Pi out to that impatient crowd of enthusiasts. What matters is the kind of reception the device gets when it arrives in schools”

It had originally hoped to produce the devices in the UK - "we want to help bootstrap the UK electronics industry" the group wrote in a blog post - but that turned out not to be possible at the right price.

But while production remains overseas, deals with two distributors, Premier Farnell and RS Components, mean that production volumes will be able to grow much faster than previously thought.

Rather than the foundation having to fund production, distributors have agreed to handle orders and deal with manufacturers paying the foundation a royalty on sales.

Mr Upton says that will help the project grow much more quickly then previously thought.

"We didn't realise how successful this was going to be," he said.

"This means we can scale to volume. Now we can concentrate on teaching people to program."

Source

Leap year: 10 things about 29 February

Leap year: 10 things about 29 February

Line up of "leaplings" from 1928

The "leap day" of 29 February exists for purely astronomical reasons, but has always prompted less scientific curiosities.

Here are 10 things to consider - for one day only. Until 2016, that is.

1. The leap year's extra day is necessary because of the "messiness" of our Solar System. One Earth year (a complete orbit around the Sun) does not take an exact number of whole days (one complete spin of the Earth on its axis). In fact, it takes 365.2422 days, give or take.

2. Until Julius Caesar came to power, people observed a 355-day calendar - with an extra 22-day month every two years. But it was a convoluted solution to the problem and feast days began sliding into different seasons. So Caesar ordered his astronomer, Sosigenes, to simplify things. Sosigenes opted for the 365-day year with an extra day every four years to scoop up the extra hours. This is how the 29 February was born. It was then fine-tuned by Pope Gregory XIII (see below).

3. Every fourth year is a leap year, as a rule of thumb. But that's not the end of the story. A year that is divisible by 100, but not by 400, is not. So 2000 was a leap year, as was 1600. But 1700, 1800 and 1900 are not leap years. "It seems a bit arbitrary," says Ian Stewart, emeritus professor of mathematics at Warwick University. But there's a good reason behind it.

"The year is 365 days and a quarter long - but not exactly. If it was exactly, then you could say it was every four years. But it is very slightly less." The answer arrived at by Pope Gregory XIII and his astronomers when they introduced the Gregorian calendar in 1582, was to lose three leap days every 400 years. The maths has hung together ever since. It will need to be rethought in about 10,000 years' time, Stewart warns. But by then mankind might have come up with a new system.

PM's Leap Day

All this month on PM, listeners have been asked whether they'd be prepared to take advantage of this extra day to do something different.

It transpires there are a lot of people who're ready to use today to take a leap.

There's the apparently mundane... "I resolve to speak Mandarin all day long"… "my partner and I are going to visit some elderly people"... "often meant to take a roof tour of Lincoln Cathedral but never got round to it".

After six years one woman will finally decide the wording for her husband's headstone. Some people are at last scattering the ashes of loved ones having put it off for years.

There's a woman taking up the hula-hoop after more than 50 years.

One woman intends to have some chocolate today - her anorexia has been a problem for years. A man who suffers panic attacks will try to make a bus journey. And a woman in her 60s will get a tattoo.

PM is on BBC Radio Four, Monday to Saturday at 17:00 GMT

PM blog

4. Why is February 29, not February 31, a leap year day? All the other months have 30 or 31 days, but February suffered from the ego of Roman Emperor Caesar Augustus, says Stewart. Under Julius Caesar, February had 30 days, but when Caesar Augustus was emperor he was peeved that his month - August - had only 29 days, whereas the month named after his predecessor Julius - July - had 31. "He pinched a couple of days for August to make it the same as July. And it was poor old February that lost out," says Prof Stewart.

5. The tradition of a woman proposing on a leap year has been attributed to various historical figures. One, although much disputed, was St Bridget in the 5th Century. She is said to have complained to St Patrick that women had to wait too long for their suitors to propose. St Patrick then supposedly gave women a single day in a leap year to pop the question - the last day of the shortest month. Another popular story is that Queen Margaret of Scotland brought in a law setting fines for men who turned down marriage proposals put by women on a leap year. Sceptics have pointed out that Margaret was five years old at the time and living far away in Norway. The tradition is not thought to have become commonplace until the 19th Century.

It is believed that the right of every woman to propose on this day goes back to the times when the leap year day was not recognised by English law. It was believed that if the day had no legal status, it was acceptable to break with tradition.

6. A prayer has been written by a female cleric for people planning a leap year day marriage proposal. The prayer, for 29 February, asks for blessings on the engaged couple. It reminds them that wedding plans should not overtake preparations for a lifetime together. The prayer has been taken from Pocket Prayers of Blessing by the Venerable Jan McFarlane, Archdeacon of Norwich:

"God of love, please bless N and N as they prepare for the commitment of marriage. May the plans for the wedding not overtake the more important preparation for their lifetime together. Please bless their family and friends as they prepare for this special day and may your blessing be upon them now and always. Amen."

7. The practice of women proposing in a leap year is different around the world. In Denmark, it is not supposed to be 29 but 24 February, which hails back to the time of Julius Caesar. A refusal to marry by Danish men means they must give the woman 12 pairs of gloves. In Finland, it is not gloves but fabric for a skirt and in Greece, marriage in a leap year is considered unlucky, leading many couples to avoid it.

8. The chance of being born on a leap day is often said to be one in 1,461. Four years is 1,460 days and adding one for the leap year you have 1,461. So, odds of 1/1,461.

But Stewart points out that is very slightly out, owing to the loss of the three leap years every 400 years. In any case, babies are more likely to be born at certain times of the year rather than others, due to a range of other factors, he says. Babies born on 29 February are known as "leapers" or "leaplings".

9. Other calendars apart from the Gregorian require leap years. The modern Iranian calendar is a solar calendar with eight leap days inserted into a 33-year cycle. The Indian National Calendar and the Revised Bangla Calendar of Bangladesh arrange their leap years so that the leap day is always close to 29 February in the Gregorian calendar.

10. Explorer Christopher Columbus used the lunar eclipse of 29 February 1504 to his advantage during his final trip to the West Indies. After several months of being stranded with his crew on the island of Jamaica, relations with the indigenous population broke down and they refused to continue helping with food and provisions. Columbus, knowing a lunar eclipse was due, consulted his almanac and then gathered the native chiefs on 29 February. He told that God was to punish them by painting the Moon red. During the eclipse, he said that God would withdraw the punishment if they starting co-operating again. The panicked chiefs agreed and the Moon began emerging from its shadow.

Also of a supernatural nature, on 29 February 1692 the first warrants were issued in the Salem witchcraft trials in Massachusetts.

Source

New twist in antimatter mystery

New twist in antimatter mystery

CDF (Fermilab)
CDF was one of two multi-purpose experiments at the US Tevatron accelerator near Chicago

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Physicists have taken a step forward in their efforts to understand why the Universe is dominated by matter, and not its shadowy opposite antimatter.

A US experiment has confirmed previous findings that hinted at new phenomena outside our understanding of physics.

The results show that certain matter particles decay differently from their antimatter counterparts.

Such differences could potentially help explain why there is so much more matter in the cosmos than antimatter.

The findings from scientists working on the CDF experiment have been presented at a particle physics meeting in La Thuile, Italy.

CDF was one of two multi-purpose experiments at the now-defunct Tevatron particle smasher in Illinois.

Physicists think the intense heat of the Big Bang should have forged equal amounts of matter and its "mirror image" antimatter. Yet today we live in a Universe composed overwhelmingly of matter.

Antimatter is relatively uncommon, being produced at particle accelerators, in nuclear reactions or by cosmic rays. Getting to the bottom of where all this antimatter went remains one of the great endeavours of particle physics.

The latest results support findings from the LHCb experiment at the Large Hadron Collider, which were announced in November 2011.

Both CDF and LHCb have been looking at the process by which sub-atomic particles called D-mesons decay - or transform - into other ones. For example, D mesons are made up of particles known as charm quarks, and can decay into kaons and pions.

Our best understanding of physics so far, known as the Standard Model, suggests the complicated cascades of decay of D-mesons into other particles should be very nearly the same - within less than 0.1% - as a similar chain of antimatter decays.

But the LHCb team reported a difference of about 0.8%, and the team from CDF have now presented data showing a difference of 0.62%.

lhcb LHCb is an enormous detector designed to examine CP violation

Getting such a similar measurement as LHCb was "a bit of a surprise", according to CDF's spokesperson Giovanni Punzi, because it is a "very unusual result".

He told BBC News: "That two separate experiments have found this using different methods - different environments - is very interesting."

Prof Punzi, from the University of Pisa and Italy's National Nuclear Physics Institute (INFN), said this was likely to "change the minds of many people about this being just one of those effects, to something that will be considered a confirmed observation - because of this independent result".

Statistics of a 'discovery'

Quarter
  • Particle physics has an accepted definition for a "discovery": a five-sigma level of certainty
  • The number of standard deviations, or sigmas, is a measure of how unlikely it is that an experimental result is simply down to chance rather than a real effect
  • Similarly, tossing a coin and getting a number of heads in a row may just be chance, rather than a sign of a "loaded" coin
  • The "three sigma" level represents about the same likelihood of tossing more than eight heads in a row
  • Five sigma, on the other hand, would correspond to tossing more than 20 in a row
  • Unlikely results can occur if several experiments are being carried out at once - equivalent to several people flipping coins at the same time
  • With independent confirmation by other experiments, five-sigma findings become accepted discoveries

He explained that when the results from CDF and LHCb are combined, the statistical significance almost reaches the four sigma level of certainty. This equates to roughly a one in 16,000 chance that the observation is down to some statistical quirk in the data.

Dr Tara Shears, a particle physicist from Liverpool University, who works on the LHCb experiment, told BBC News: "We don't know yet if we are seeing the first signs of new physics, or are starting to understand the Standard Model better.

"What we've seen is a hint that's worth looking into. And the fact that CDF see the same effect as LHCb is confirmation that this is really worth doing."

These views were echoed by Giovanni Punzi: "This effect is definitely much larger than anything that had been predicted. So there will be discussions between the theoreticians, asking: 'Is this really new physics, or did we get our calculations wrong?'"

The dominance of matter in the Universe is possible only if there are differences in the behaviour of particles and anti-particles.

Physicists had already seen such differences - known as called "CP violation". But these known differences are much too small to explain why the Universe appears to prefer matter over anti-matter.

One other experiment has shown a significant "asymmetry" of matter over antimatter. In June 2010, physicists working on the Tevatron's DZero experiment reported seeing a 1% difference in the production of pairs of muon (matter) particles and pairs of anti-muons (antimatter).

The Tevatron was shut down in September last year, after the American government rejected a proposal to fund it until 2014, but scientists continue to analyse data gathered up to the end of operations.

Source

Google Fiber: Can ultra-fast internet change a city?

Google Fiber: Can ultra-fast internet change a city?

VIDEO: People in Kansas City discuss the arrival of Google's super-fast internet

Google is installing super-fast fibre optic internet service in Kansas City. Will it usher in a new era in industry and society - or just enable faster web browsing and media downloads?

For technology consultant Bret Rhodus, Google's newest venture is an amazing business opportunity.

"This can be a game-changer," he says. "The opportunity for entrepreneurs is significant."

For art supply clerk Danni Parelman, however, it's just a chance to download more music.

The California internet giant has begun installing fibre optic cable that will give Kansas City residents download speeds of up to 1Gbps - about 100 times faster than the broadband internet service currently available to most Americans.

'The future'?
Danni Parelman Danni Parelman says the high speed internet will enable her to download music faster

In dozens of interviews in the streets, shops, offices and cafes of Kansas City - a metropolitan area that straddles the Kansas-Missouri state line - residents and business people agreed that the project would be great for the town.

Analysts say the project, called Google Fiber, is the future of the web.

But the speed will be so much faster than what is currently available that even people familiar with the concept have a hard time imaging how it will affect industries and lives.

Although the seeds of the internet germinated in US Department of Defense laboratories and many of the most innovative internet companies are based in the US, Americans have far slower internet than residents of many other industrialised nations.

Google Fiber details

  • In March, Google chose the Kansas City metropolitan area from more than 1,100 cities and towns that requested the service
  • Google crews have begun hanging fibre lines from utility polls in selected neighbourhoods
  • The service will launch in residential neighbourhoods only - no commercial districts - the first half of 2012
  • About two million people live in the Kansas City metropolitan area, but Google has not said how many will have access to the service
  • Google has not said how much the monthly service will cost, but says it will be "competitive"

Source: BBC research

The average broadband internet speed across the US is 12.84 Mbps, according to Netindex.com. That makes the US 31st in the world (the UK is 32nd with 12.4 Mbps speed).

The ultra-high-speed unleashed by the fibre optic technology is a natural progression in the development of America's telecommunications infrastructure, says Aaron Deacon, a member of the board of the Social Media Club of Kansas City and a technology marketing consultant.

"This is the way the world is heading," he says.

"There are other places around the world that have this kind of connectivity, but around the US adoption has been pretty slow."

Uncertain impact

But what will be super-fast internet's affect on the town in practical terms?

Aaron Deacon Aaron Deacon says: "Being the first for a new infrastructure is kind of a double-edged sword"

At first, the ultra-high-speed could simply mean people use the same web sites and internet services they already do, just faster.

"People say, 'oh it's going to just be faster YouTube'. It's sort of a joke," says Mr Deacon.

"But actually to have fast YouTube and videos with no buffering, and instantaneous downloading of feature movies, is a pretty significant change in the way that video can work."

The high speed will enable small businesses and home-office workers to have high-definition video conferencing without the hiccups, lag-time, and buffering slogs frequently suffered with cable or DSL broadbased.

It will allow greater use of cloud computing by small businesses, for example by allowing them to keep customer databases and accounting systems online instead of in costly local servers.

"Once business people can collaborate and work together and they don't have to worry about lag times - when you're not frustrated with the limitations of internet speeds - things really start jiving and amazing things get done," says Dave Greenbaum owner of a Kansas City computer repair company, who predicts a burst of small business innovation.

Aside from the expected boon to businesses, analysts predict almost every aspect of people's personal lives could be affected.

Having affordable super-fast internet in the home will enable faster and more efficient telecommuting, which could take cars off the roads, analysts say.

Holograms and MRIs

Average broadband download speeds, in Mbps

  • South Korea: 32.96
  • Lithuania: 31.78
  • Latvia: 26.78
  • Sweden: 25.26
  • Romania: 24.80
  • Netherlands: 24.61
  • Singapore: 22.84
  • Bulgaria: 22.26
  • US: 12.76
  • UK: 12.44

Source: Netindex.com, based on volunteers who have tested their own connections through the speedtest.net

Doctors and hospitals will more easily be able to transmit data-heavy medical images like MRI scans. Businesses or local governments could install "dumb terminals" - computers with little more than a screen, keyboard, mouse and internet connection - across the city.

Communities could establish shared music, film and e-book libraries. High definition - even holographic - video conferencing could enable greater participation in local government: "Town hall in the home" is one catchphrase. Public safety could be improved by higher definition CCTV and video emergency calling.

Elsewhere in the US, an electric power firm in Chattanooga, Tennessee now offers 1Gbps internet to its customers - the broadest community-wide rollout of fiber optic connectivity in the nation.

But with its high cost for residential customers - about $350 (£223) a month - only nine have signed up, says EPB's spokeswoman Danna Bailey.

"It's not going to happen overnight," she says.

"It's a bit of a curiosity."

Google fiber video Google published web videos and a blog promoting its service to Kansas City residents

And in Britain, BT says it will begin offering 300Mbps - less than one-third of Google Fiber's advertised speed - in 2013.

Shift to wifi

Despite the overwhelming enthusiasm in Kansas City for Google Fiber, people familiar with it warn of potential pitfalls.

"Being the first for a new infrastructure is kind of a double-edged sword," Mr Deacon says.

"It can be a really great thing, and it can build a leadership position around that, but you're also sort of a guinea pig, so if you're not smart about how you use that opportunity you can be the bad example that somebody else learns from."

Since Google first announced plans to install the fibre network in 2010, internet users' attention has shifted away from desktop internet to mobile internet, as consumers spend more and more time on smart phones, tablets and other mobile devices, says Ed Malecki, a professor of geography at Ohio State University who studies technology and economic development.

As mobile providers tighten up on cellular data use, consumers will have greater need for high-speed wifi where ever they go in their home towns, he says.

Downtown Kansas City Residents said they hoped the project would help Kansas City outgrow its reputation as a "cow town"

"If Google wants to make super-fast community wifi, fine," he says. Google fiber is "not going to help anybody unless it's translated into wifi."

Meanwhile, Ms Bailey of EPB notes past world-changing technologies took years to have a broader impact.

"When electric power first became widely available in homes, it was a more convenient, somewhat novel alternative to the oil lamp for lighting," she says.

"At that time, it would have taken an incredible visionary to predict what kind of an impact electric power would have on business and ultimately quality of life."

Source

Neverending DNA and Immortal Worms

Neverending DNA and Immortal Worms

How Israel might strike at Iran

How Israel might strike at Iran

Israeli Air Force F-16 An Israeli attack would have to cope with a variety of problems

For all the myriad challenges facing Israel over the past decade it is the potential threat from a nuclear-armed Iran that has preoccupied the country's military planners.

It is this that in large part has guided the development of the Israeli Air Force (IAF) over recent years.

The IAF has purchased 125 advanced F-15I and F-16I warplanes, equipped with Israeli avionics and additional fuel tanks - tailor-made for long-range strike missions.

In addition, Israel has bought specialised bunker-busting munitions; developed large, long-endurance, unmanned aircraft; and much of its training has focused on long-range missions.

Israel has a track-record of pre-emptive strikes against nuclear targets in the region.

Remains of the Osirak nuclear site outside Baghdad (2002) Israel has a track-record of pre-emptive strikes against nuclear targets

In June 1981, Israeli jets bombed the Osirak reactor near the Iraqi capital, Baghdad.

More recently, in September 2007, Israeli warplanes attacked a facility in Syria that Israel, the US and many experts believed was a nuclear reactor under construction.

However, a potential strike against Iran would be nothing like the attacks in Iraq and Syria. These were both against single targets, located above ground, and came literally out of the blue.

An Israeli attempt to severely damage Iran's nuclear programme would have to cope with a variety of problems, including range, the multiplicity of targets, and the nature of those targets.

Many of these problems are daunting in themselves, but when put together, they only compound the difficulties facing Israeli military planners.

How to get there?

For a start it is a very long way from Israel to Iran. As a rough estimate many of the potential targets are some 1,500km (930 miles) to 1,800km (1,120 miles) from Israeli bases. Israeli warplanes have to get to Iran and, equally important, get back.

At least three routes are possible.

  • There is the northern one where Israeli jets would fly north and then east along the borders between Turkey and Syria, and then Turkey and Iraq
  • The central, more likely route would take Israeli warplanes over Iraq. With the US military gone, the Iraqi authorities are far less able to monitor and control their air space, effectively opening a door to an Israeli incursion
  • The third, southern route would take Israeli jets over Saudi air space. Would the Saudis turn a blind eye to such a move given their own concerns about Iran's nuclear programme? Could this route be used by Israeli aircraft on the return leg of their journey? We just do not know
Map showing possible routes Israeli aircraft might take to bomb Iranian nuclear sites

What we do know, given the range, is that Israeli aircraft will have to be topped up with fuel en route.

Douglas Barrie, senior fellow for military aerospace at the International Institute for Strategic Studies (IISS) in London, says that "air-to-air refuelling will be critical".

Israeli F-15 fighter jets refuel during an air show at the graduation ceremony of Israeli pilots in the Hatzerim air force base in the Negev desert near the southern Israeli city of Beersheva on June 30, 2011 Israel is believed to have between eight and 10 large tankers based on the Boeing 707 airframe

"Israeli aircraft," he says, "need not just to get in and out of Iranian air space; they need to have enough fuel to provide time over their targets and they need sufficient fuel to cover any contingencies that might arise during the mission."

The initial tanking, Mr Barrie says, might be done over the Mediterranean or even in Israeli airspace. "One option," he notes, "would be to take off with a full bomb load and drop tanks containing additional fuel; to climb to cruising altitude and then at this point to replenish their tanks, before setting course for their targets in Iran."

Israel is believed to have between eight and 10 large tankers based on the commercial Boeing 707 airframe, but experts believe that tanking capacity will prove one of the limiting factors in the scope of any operation.

What targets to hit?

The problems of range, the nature of some of the targets, and the availability of tanker aircraft will determine the nature and scope of any Israeli operation.

Iran nuclear sites

A general view of the water facility at Arak on January 15, 2011

Natanz - Uranium enrichment plant

Fordo, near Qom - Uranium enrichment plant

Arak (pictured) - Heavy water plant

Isfahan - Uranium conversion plant

Parchin - Military site

Douglas Barrie, of the IISS, says that "Israeli planners will be looking for where they can do most damage with the limited number of platforms at their disposal".

"They'll be asking where the main choke points are in the Iranian programme. Clearly, striking enrichment facilities makes a lot of sense from a military point of view," he adds.

So the uranium enrichment facilities at Natanz, south of Tehran, and Fordo, near the holy city of Qom, would almost certainly be prominent on the target list.

The heavy-water production plant and heavy-water reactor under construction at Arak, in the west, might also figure, as would the uranium conversion facility at Isfahan.

It is unclear whether Israel would have the capacity to strike a range of other targets associated with Iran's missile programmes and explosives testing.

But this target list raises another set of problems. The enrichment facilities at Natanz are underground and the new plant at Fordo is buried deeply into the side of a mountain.

Can Israel destroy buried targets?

For an attack like this, says Douglas Barrie, you need good intelligence information. "You need to know", he says, "about the geography of the target site; its geology; the nature of the earth; and the details of the design and construction of any buried reinforced concrete chambers."

"You can assume," he asserts, "that the Americans and the Israelis have been watching these sites closely over time."

“Start Quote

The target would have to be attacked from relatively close range, meaning any attacking force will have to fight its way in and out of heavily-contested airspace”

Robert Hewson IHS Jane's Air-Launched Weapons

To reach buried targets you need special kinds of munitions. Deeply-buried facilities are not exclusive to the Middle East. There is a kind of race between the diggers and the weapons designers and it is one where the Americans have considerable experience.

The main weapon in Israel's arsenal is the US-supplied GBU-28. This is a 5,000lb (2,268kg) laser-guided weapon with a special penetrating warhead. For an assessment of its capabilities I turned to Robert Hewson, the editor of IHS Jane's Air-Launched Weapons.

"The GBU-28," he told me, "is the largest penetrating weapon available for a tactical aircraft and, since it was first used by the US in 1991, it has been improved with better warheads and more accurate guidance.

"However, Israel's use of this weapon would be hindered by several key operational factors. Realistically, the F-15I - the only delivery platform - can carry only one bomb, so a sizeable attack force would be required - demanding tanker and other support assets that Israel does not have in large numbers.

"The target would have to be attacked from relatively close range, meaning any attacking force will have to fight its way in and out of heavily-contested airspace."

Furthermore, he says that "very accurate targeting data is required to use a weapon like GBU-28 to best effect".

"The potential for success of a GBU-28 attack is not determined by the 'book' performance of the weapon alone."

Of course, the great unknown question is how capable these weapons would be against buried Iranian enrichment facilities at Natanz and Fordo.

Israel's 'Bunker Buster' bomb

Israel's 'bunker buster' bomb

1. The bombs are carried by Israeli F-15Is - but only one per aircraft, which would mean a large attack force for multiple attempts on numerous targets

2. Bomb is released almost vertically over the target, and guided by lasers

3. The bombs can penetrate up to 6m of concrete or about 30.5m of earth before detonating the 4,400lb warhead

Mr Hewson says that the GBU-28 is "effective against any hardened or deeply buried target - up to a point".

"For a weapon like the GBU-28, velocity and angle of impact determine the penetrating effect, so the ideal drop is made from high altitude at maximum speed and hits the target at a near vertical angle," he explains.

"This is less easy to do against a cave or mountainside, so the weapon will be less effective - but still more effective than pretty much any other available munitions."

Indeed, as Douglas Barrie notes, one weapon might be insufficient.

"You could", he says, "attempt to 'dig your way in' using several weapons on the same impact area to try to get through the soil, rock and concrete. Or you could try to block access to the facility by destroying tunnel entrances.

"In addition," he says, "all of these facilities are power hungry, so you could attempt to destroy power supplies and any buried cabling.

"The aim would be to present the Iranians with a compound problem of blocked entrances, no power and collapsed underground chambers."

Does Israel have other military options?

So far we have discussed only the known elements of Israel's capabilities, mainly US-supplied aircraft and munitions. But Israel has a hugely advanced aerospace and electronics industry of its own and this may well have produced systems relevant for an attack against Iran.

The Eitan, the Israeli Air Force's latest generation of Unmanned Aerial Vehicle (UAV), flies over a ceremony introducing it into the 210th UAV squadron on February 21, 2010 at the Tel Nof air base in central Israel. The Eitan, or Heron TP, weighs in at 5,000 kgs and has a 26 meter wingspan. It can carry a heavy payload, is equipped with more advanced technological systems than its predecessors and has a 20-hour high-altitude flying time. The Eitan, the Israeli Air Force's latest generation of Unmanned Aerial Vehicle

Douglas Barrie says that there is much about Israel's capabilities, especially its home-grown technology, that we do not know.

"Israel's long-range Heron or Eitan drone could be used to gather an assessment of the damage done by any strikes, but perhaps could also be put to use helping to spoof air defences," he adds.

"Indeed, this kind of deception or cyber-operation will likely be an integral part of the mission with the aim of blinding radars or generating a false picture of what was going on."

What about Iran's air defences?

Iran's air defences are largely Russian-supplied systems familiar to Israeli pilots, though Iran also deploys the US-built Hawk system dating back to the days of the Shah.

Iran's defences

Hawk surface-to-air missiles (bottom-C) are seen in Khandab near Arak, 290 kms (180 miles) southwest of the Iranian capital Tehran, during military manoeuvres on November 26, 2009.

Surface-to-air missiles - Hawk system (pictured)

For high altitude targets - SA-5 or S-200

For low level targets - Tor-M1/SA-15 Gauntlet

Long-range systems - S-300

Iranian Air Force - Russian-built Mig-29s, US-built F-14 Tomcats

Some of its most capable defences are Russian SA-5 missiles intended to target high-altitude threats, while it also deploys the mobile Tor-M1/SA-15 Gauntlet system optimised to engage targets at lower level.

Russia has consistently refused to supply Iran with the much more capable S-300 long-range system, though the Iranians claim to have procured some batteries elsewhere.

Iran's surface-to-air missile force may be old but still represents a threat. Look at how much effort Nato and the US put into taking down Libya's similar vintage air defences last year.

Israel will not have the time or the resources to embark upon this kind of protracted air campaign and thus the electronic element of any strike to suppress Iranian defences is likely to be as important as the actual dropping of weapons.

Israel's small submarine force could potentially play a role here too. Douglas Barrie says that "there must be a reasonable assumption that Israel has an operational sea-launched cruise missile capability based upon their German-built Dolphin submarines".

Escorted by navy missile ships, Israeli submarine 'Dolphin' sails along the Mediterranean Sea near the coastal city of Tel Aviv during special naval maneuvers ahead of Israel?s 60th independence anniversary on May 5, 2008. The 'Dolphin', a German-built submarine, is 56.4m long with a cruising range of 4500 nautical miles. It is armed with ten 21-inch multi-purpose tubes for torpedoes, mines, missiles and decoys. Israel's small submarine force could play a role

"These could be used to go after older but capable SA-5 air defence sites and big search and surveillance radars."

But, he notes: "Adding a naval dimension complicates the co-ordination of any attack."

Iran's air force is seen by experts as being totally outclassed by its Israeli counterpart.

It has a small number of US-built F-14 Tomcat fighters and a significant number of relatively more modern Russian-supplied MiG-29s.

But the potential threat from Iranian aircraft again complicates Israeli planning and any air-to-air combat might place additional strains on the limited fuel supplies carried by the attacking aircraft.

Would an Israeli strike succeed?

Most experts agree that Israel could hit multiple targets in Iran and do considerable damage to its nuclear programme. They would, however, do much less damage than a full-scale US attack using all of the resources at Washington's disposal.

“Start Quote

Even if successful, it would only delay Iran's nuclear programme”

Douglas Barrie International Institute for Strategic Studies

The Israelis would be operating at the very limits of their capabilities. "If they pulled it off," says Douglas Barrie, "it would be an impressive display of power projection against a difficult and dispersed set of targets."

Only a small number of air forces in the world, he notes, could mount such an operation. But, Mr Barrie stresses: "Even if successful, it would only delay Iran's nuclear programme."

It is a point echoed by IHS Jane's Robert Hewson.

"Israel does not have the mass of forces and will not be given the operational freedom [by Iran] required to destroy Iran's nuclear complex," he says. "If you bury enough stuff deep enough, enough of it will survive. Any Israeli attack can only damage and possibly not even slow the Iranian effort.

"The consequences of such an attack would be dire and global. It is impossible to see any up-side to this venture."

That's a view shared for now by Israel's most important ally.

Only a few days ago, the Chairman of the US Joint Chiefs of staff, Gen Martin Dempsey, said that an Israeli attack would not be prudent.

Such a strike, he said, "would be destabilising and would not achieve their long-term objectives".

However Israel's calculus is very different. Knowing all their operational limitations, might they launch such an operation anyway?

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