Tuesday, February 14, 2012

When Charles Dickens fell out with America

When Charles Dickens fell out with America

Portraits of Charles Dickens in 1860
Photography was in its infancy in the 1840s. These portraits date from 1860

On his first visit to America in 1842, English novelist Charles Dickens was greeted like a modern rock star. But the trip soon turned sour, as Simon Watts reports.

On Valentine's Day, 1842, New York hosted one of the grandest events the city had ever seen - a ball in honour of the English novelist Charles Dickens.

Dickens was only 30, but works such as Oliver Twist and the Pickwick Papers had already made him the most famous writer in the world.

The cream of New York society hired the grandest venue in the city - the Park Theatre - and decorated it with wreaths and paintings in honour of the illustrious visitor.

There was even a bust of Dickens hanging from one of the theatre balconies, with an eagle appearing to soar over his head.

Dickens and his wife, Catherine, danced most of the night in the company of around 3,000 guests.

"If I should live to grow old," the novelist told a dinner the following night, "the scenes of this and other evenings will shine as brightly to my dull eyes 50 years hence as now".

But a visit which had started so well quickly turned into a bitter dispute, known as the "Quarrel with America".

Enthusiastic fans

“Start Quote

I am disappointed.... This is not the republic of my imagination”

Charles Dickens in a letter to his friend, William Macready

As a committed social reformer, Dickens wanted to use his trip to find out if American democracy was an improvement on class-ridden Victorian England.

The novelist particularly enjoyed Boston, his first port of call.

His hosts watched in amazement as he charged through the snowy streets with delight, reading aloud the signs on the shops.

But little by little, the enthusiasm of his American fans began to overwhelm him.

When Dickens's boat made a stopover in Cleveland, he awoke to find a "party of gentlemen" staring through the cabin window as his wife lay in bed.

"If I turn into the street, I am followed by a multitude," Dickens complained in a letter.

"I can't drink a glass of water, without having 100 people looking down my throat when I open my mouth to swallow."

'Fellow animals'

The novelist was particularly irritated by Americans who tried to make money out of his fame.

Find out more

  • Dickens in America by Simon Watts was broadcast on the BBC World Service history programme Witness

In New York, the jewellers Tiffany's had made copies of a Dickens bust and an enterprising barber is said to have tried to sell locks of the writer's hair.

Then, there were the table manners of the Americans that Dickens was forced to share meals with as he travelled around the country.

In his travel book, American Notes, Dickens describes Mid-Westerners at dinner as "so many fellow animals", who "strip social sacraments of everything but the mere satisfaction of natural cravings".

"The longer Dickens rubbed shoulders with Americans, the more he realised that the Americans were simply not English enough," says Professor Jerome Meckier, author of Dickens: An Innocent Abroad.

"He began to find them overbearing, boastful, vulgar, uncivil, insensitive and above all acquisitive."

'Tobacco-tinctured saliva'

Dickens had scheduled a whole week in Washington to see if American politics lived up to his high hopes.

A scene from Martin Chuzzlewit, which was published in 1843-4 Martin Chuzzlewit was written after Charles Dickens returned to England from his North American trip

He visited the Capitol, met American politicians and attend President John Tyler's morning reception at the White House.

But by now Dickens was in such a foul mood that his enduring memory of the city was the tobacco-spitting he saw in the streets.

"Washington may be called the head-quarters of tobacco-tinctured saliva," Dickens fumed in American Notes. "The thing itself is an exaggeration of nastiness, which cannot be outdone."

As for the politicians, Dickens concluded that, like everyone else in America, they were motivated by money, not ideals.

"I am disappointed," he wrote in a famous letter. "This is not the republic of my imagination."

Washington, Dickens blasted in American Notes, was the home of: "Despicable trickery at elections; under-handed tamperings with public officers; and cowardly attacks upon opponents, with scurrilous newspapers for shields, and hired pens for daggers".

Pirated editions

By this stage in the trip, Americans were as annoyed with Dickens as the novelist was with them.

The issue was a very modern one - intellectual property.

Courier and Enquirer's furious response to American Notes:

James Watson Webb, editor of the Courier and Enquirer (Picture between 1855 and 1865)

Mr Dickens is a young man who knows nothing of this world, of society, or of government, but what he picked up as a "flash reporter" and penny-a-liner when connected with some of the most scurrilous of the vile presses with which London abounds. No person of ordinary intelligence can get up from the perusal of these "notes" without feeling that the great aim of the writer is produce the impression among the English readers that he is really somebody, and possesses all those niceties of feeling and sensitiveness of contact with the vulgar mass, so frequently assumed by the low-bred scullion unexpectedly advanced from the kitchen to the parlour...

Courier and Enquirer, 17 November 1842

In 1842, there were no international copyright laws so Americans could read Dickens's works for free in pirated editions.

Once Dickens saw how popular he was in the US, he realised he could virtually double his income if his American fans started paying a going rate for his work.

"I am the greatest loser alive by the present law," he complained in letters home.

Dickens raised the matter with his American audiences as tactfully as he could.

At literary dinners, he argued that a copyright law would help American writers as much as him, and he stressed that he would "rather have the affectionate regard of my fellowmen as I would have heaps and mines of gold".

But the American press turned on Dickens, accusing him of mixing pleasure and business.

"We are mortified and grieved that he should have been guilty of such great indelicacy and impropriety," said the New York Courier and Enquirer, then the country's most popular paper.

"The entire press of the Union was predisposed to be his eulogist, but he urged those assembled (not just to) do honour to his genius, but to look after his purse also."

Dickens's visit to America ended with both sides accusing each other of being vulgar money-grabbers.

'Traitor'

On his return to England, Dickens published two books about his American trip.

As well as the scathing travel writing of American Notes, he satirised the country viciously in a section of Martin Chuzzlewit, his next major novel.

To the American press, the books were a libel on their country.

"We are all described as a filthy, gormandizing race," raged an article in the Courier and Enquirer, which was edited by James Watson Webb.

It described Dickens as a "low-bred scullion... who for more than half his life has lived in the stews of London".

Many of the friends Dickens had made in America, such as the novelist, Washington Irving, were also outraged and struggled to forgive him for ridiculing their country in print.

"Americans felt they'd welcomed Dickens into their country as a hero," says Prof Meckier, "and now there was a sense he was a traitor."

'Silver sunshine'

For some Dickens scholars, the "Quarrel With America" marks a significant shift in his work.

"Dickens had a traumatising experience in America," argues Prof Meckier. "He became less radical, less optimistic, and he downgraded his view of human nature."

Highlights of Charles Dickens's 1842 itinerary

  • January 22: Arrived Boston
  • February 2: Visited mills at Lowel, Massachusetts
  • February 13: Arrived New York by boat
  • February 14: Ball at Park Theatre
  • March 2: Visited Tombs Prison and Public Department
  • March 6: Arrived Philadelphia
  • March 10: Visited Capitol and White House
  • March 13: Dinner at the White House
  • March 29: Arrived Pittsburgh
  • April 4: Arrived Cincinnati
  • April 10: Arrived St Louis
  • April 26- May 3: Niagara Falls
  • May 4- 29: Visited Canada
  • June 7: Left New York for England

Source: Charles Dickens in America by William Glyde Wilkins

Dickens expressed his darker world view in later novels such as David Copperfield and Bleak House.

But despite the "quarrel", these books sold as well as his early works. And it was the novelist's enduring popularity with American readers that eventually ended the dispute.

Towards the end of his life, Dickens began holding wildly popular public readings from works such as A Christmas Carol.

He sent a scout to assess if the American public would react as well as his fans in England, and after getting favourable reports, he returned to the US in 1867 and 1868.

Dickens needn't have worried about his reception.

"To say that his audience followed him with delight hardly expresses the interest with which they hung upon his every word," wrote the Boston Journal.

"It was not Dickens, but the creation of his genius, that seemed to live and talk before the spectators."

Almost all of Dickens's American critics were won over by his performances, and the quarrel was declared to be over.

"Dickens' second coming was needed to disperse every cloud and every doubt," said the New York Tribune, "and to place his name undimmed in the silver sunshine of American admiration".

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Google Motorola bid approved in EU and US

Google Motorola bid approved in EU and US

Google Xoom tablet Google aims to strengthen its patent portfolio with the Motorola takeover

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US regulators have approved Google's $12.5bn (£7.9bn) bid for phone maker Motorola Mobility, hours after it won clearance from European authorities.

The European Commission ruled the deal would not raise competition issues in the market for operating systems for devices like mobile phones or tablets.

Regulators in the US agreed, although both authorities vowed to monitor the company and rivals' use of patents.

Approval from China, Taiwan and Israel is needed before the deal is completed.

Motorola split in two last year, prompting Google to bid for the section that makes phones and tablet computers in a bid to gain access to more than 17,000 of Motorola Mobility's patents.

'Important milestone'

EU Competition Commissioner Joaquin Almunia said in a statement that regulators did not think the deal would diminish competition.

But he added: "The commission will continue to keep a close eye on the behaviour of all market players in the sector, particularly the increasingly strategic use of patents."

Last month, European regulators launched an investigation into whether Samsung was using some of its key patents to hinder competitors.

Google vice-president Don Harrison said in a blog post the EU approval was an "important milestone" which moved the company closer to closing the deal.

Android access

"As we outlined in August, the combination of Google and Motorola Mobility will help supercharge Android," he said.

"It will also enhance competition and offer consumers faster innovation, greater choice and wonderful user experiences."

The European Commission had originally intended to rule on the deal by 10 January but delayed its decision after requesting more information.

It wanted to examine whether Google might favour Motorola Mobility by making it harder for big-selling handset manufacturers, like Samsung or HTC, to use its Android operating system.

However, the commission concluded: "It is unlikely that Google would restrict the use of Android solely to Motorola, a minor player in the European Economic Area."

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Monday, February 13, 2012

Masdar - the carbon neutral city

Masdar - the carbon neutral city

Powered by the sun, cooled by wind, the car-free environment of Masdar is working to become the world's first carbon neutral city in the United Arab Emirates.

Fiona Foster investigates whether the city is a model for the future or just a green mirage.

Get in touch with Fast Track via email or Facebook.

Watch Fast Track on the BBC World News channel on Saturdays at 04:30, 13:30 and 19:30 GMT or Sundays at 06:30 GMT.

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Sunday, February 12, 2012

Poor America: 'Some kids are making ketchup soup'

Poor America: 'Some kids are making ketchup soup'

Panorama's Hilary Andersson travelled to Whitney Elementary School in Las Vegas to meet some of America's youngest poor.

Children told of going to bed hungry and worrying about their families, while school officials said some children were resorting to eating "ketchup soup".

Panorama: Poor America, BBC One, Monday, 13 February at 20:30 GMT then available in the UK on the BBC iPlayer.


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Immune cells use 'starvation tactics' on HIV

Immune cells use 'starvation tactics' on HIV

HIV
The human immunodeficiency virus (HIV) attacks the immune system

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Scientists have shown how some cells in the body can repel attacks from HIV by starving the virus of the building blocks of life.

Viruses cannot replicate on their own; they must hijack other cells and turn them into virus production factories.

A study, published in Nature Immunology, showed how some parts of the immune system destroy their own raw materials, stopping HIV.

It is uncertain whether this could be used in therapy, experts caution.

HIV attacks the immune system and can weaken the body's defences to the point that everyday infections become fatal.

However, not all parts of the immune system become subverted to the virus' cause. Macrophages and dendritic cells, which have important roles in orchestrating the immune response, seem to be more resistant.

Raw materials

Last year researchers identified the protein SAMHD1 as being a critical part of this resistance. Now scientists believe they know how it works.

They have shown that SAMHD1 breaks down the building blocks of DNA. So if a cell needs to make a copy of itself it will have a pool of these building blocks - deoxynucleoside triphosphates or dNTPs - which make the new copies of the DNA. However, they can also be used by viruses.

“Start Quote

How we can use the anti-retroviral action of this protein is not clear to me”

Dr Jonathan Stoye National Institute of Medical Research

The study, by an international team of researchers, showed that SAMHD1 lowered the levels of dNTPs below that needed to build viral DNA and prevented infection. When they removed SAMHD1 then those cells had higher levels of dNTPs and were infected by HIV.

The report said: "By depleting the pool of available dNTPs, SAMHD1 effectively starves the virus of a building block that is central to its replication strategy."

It is possible for macrophages and dendritic cells to produce SAMHD1 as they are "mature cells" which do not go on to produce new cells.

Prof Baek Kim, one of the researchers from the University of Rochester Medical Center, said: "It makes sense that a mechanism like this is active in macrophages.

"Macrophages literally eat up dangerous organisms, and you don't want those organisms to have available the cellular machinery needed to replicate and macrophages themselves don't need it, because they don't replicate.

"So macrophages have SAMHD1 to get rid of the raw material those organisms need to copy themselves. It's a great host defence."

Is a world without Aids possible?

Dr Jonathan Stoye, virologist at the Medical Research Council National Institute of Medical Research, was part of the team which determined the chemical structure of SAMHD1 last year and predicted that it would attack the dNTPs.

"We hypothesised that it works in this fashion and the paper tells us we were right. It is depleting cells of these dNTPs, in cells which are not proliferating (dividing)."

However, some cells do need to divide to boost numbers as part of the immune defence. Such as CD4 cells which are the prime target for HIV infection.

"Cells which are proliferating would be in trouble if we took dNTPs away," Dr Stoye said.

He added: "How we can use the anti-retroviral action of this protein is not clear to me."

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Wednesday, February 8, 2012

Ape versus machine: Do primates enjoy computer games?

Ape versus machine: Do primates enjoy computer games?

Liz Bonin witnesses Ayumu's incredible skill

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A chimp genius can complete a computer memory test in less time than it takes the average person to blink - and much faster than any human rival. But do the world's cleverest animals enjoy these cognitive tasks?

Ayumu, who was born and raised in Japan's Kyoto University, can remember the location and order of a set of numbers in record time. Sixty milliseconds to be precise.

Of course, it is not "natural" behaviour for a chimp to interact with a computer screen, but scientists suggest this type of task could be good for captive apes.

Ayumu the chimp completes a computer game (c) BBC/Professor Tetsuro Matsuzawa Ayumu's record stands at 60 milliseconds

"Unfortunately, captive great apes often exhibit behavioural signs of boredom, frustration and stress," says Fay Clark from the Royal Veterinary College's Centre for Animal Welfare.

Working with the Zoological Society of London, Ms Clark has recently published a review of research investigating whether challenges that get captive apes thinking can enhance their well-being.

"If an ape does not receive enough cognitive challenge in life, this can lead to abnormal behaviours or a lack of interest in the environment," she tells BBC Nature.

"The key is for scientists to develop challenges which are relevant, motivating, and ultimately solvable if they are going to be used as enrichment."

Chimp's challenge

Intelligent animals:

Chimpanzees grooming (Image: Science Photo Library)

Killer whale: Different pods have developed unique "dialects". A killer whale calf is most likely to learn a dialect from its mother.

Chimp: Wild chimpanzees use at least 66 distinct gestures to communicate with each other.

Octopus: The creatures have been filmed scooping up halved coconut shells and using them as shelters.

Carrion crow: Drop hard nuts on to roads and collect the food after passing cars have cracked them.

Dolphin: Dolphins often make "play" activities more challenging for themselves as time goes on, research suggests.

Otters: Pass down shell-cracking skills to their young. It can take a pup six months to learn how to crack a shell against a stone rested on its belly.

Sumatran orangutan: Observed using objects as tools, including leaves as "toilet paper", large leaves as "umbrellas" and modifying sticks to gather insects.

As one of the world's longest-running laboratory-based studies of chimpanzees, the Ai Project has been investigating chimp intelligence for over 30 years.

Professor Tetsuro Matsuzawa began his research with a one-year-old female chimp Ai, the namesake of the project, in 1977.

Over the years the team investigated Ai's brain power by observing her as she learned to complete tasks including number and object recognition.

In 2000, Ai gave birth to a son, Ayumu, who has since become the number-crunching star of the study, and features in the series Super Smart Animals, for BBC One and the Discovery Channel.

Ayumu's daily routine resembles that of many 11-year-olds: sleep, eat, play and learn.

During his "study sessions" he receives a treat every time he correctly remembers the location of the numbers on screen and selects them in order.

"Ayumu and others can do the task with social praise. Food reward is not the essential matter," Prof Matsuzawa says.

He says the chimps all go to the testing room of their own free will, and "they love to do so".

"It is not only Ayumu but also the other young ones who have the better memory than naive human adults," he says.

Because great apes are "highly individual", it is important to tailor challenges to them, says Ms Clark.

"Some will not be motivated to interact with computer screens," she says. "Some are highly motivated by food rewards; some by human contact."

Ayumu and Prof Tetsuro Matsuzawa Ayumu completes his tasks for food but also social praise, says Prof Matsuzawa

At Zoo Atlanta in Georgia, US, a group of orangutans are being closely watched. In 2007, a touch screen cunningly disguised in a tree was installed in their enclosure.

"We have specific programmes to look at how they learn," says Dr Tara Stoinski, who leads the study. "They are not games, [the orangutans] are doing problem-solving."

The apes currently have the opportunity to match symbols to photographs on the screen and their moves are studied by researchers at Emory University.

When they correctly categorise a photograph they are rewarded with a small pellet of food.

"It's not like they're getting jackpot of sweets," says Dr Stoinski, who explains that the orangutans are content to interact with the screen even when the dispenser runs out of pellets.

"For some of them it is inherently rewarding," she tells BBC Nature.

The research team say they have made careful observations to ensure the apes are not negatively influenced by the presence of the "learning tree".

Orangutan at Zoo Atlanta uses the "learning tree" Orangutans at Zoo Atlanta continue problem solving even when food rewards run out

"We were aware that introducing the tasks could cause competition in the group which could have negative effects - it could create some tension.

"So we evaluated it from that standpoint but we didn't find that.

"Our animals they seem to be very happy with the division of labour."

In contrast to the "undercover" enrichment in Atlanta, orangutans in Milwaukee County Zoo, Wisconsin have been presented with the latest in modern technology.

Apes with iPads

Last Christmas, charity Orangutan Outreach began trialling iPad interaction with the apes.

"They've been using the paint application, they love watching videos on them but they haven't really played many complex games," says Richard Zimmerman.

A small orangutan holds an iPad Zoo keepers want to build reinforced tablets so they can leave the orangutans to play without human help

It is early days for the project yet but Mr Zimmerman tells BBC Nature that researchers at Toronto Zoo are now helping to quantify how the apes are interacting with the tablets.

"It's not really toy-like because they are engaging with them as devices... it's definitely going in the cognitive direction."

As a conservation charity, Mr Zimmerman says Orangutan Outreach's key concern is enrichment and helping to raise people's awareness of the animal's plight in the wild.

But by introducing devices to more research-focused centres, including Zoo Atlanta, they hope they will provide more scientific insights.

Orangutans are clearly fascinated by unfamiliar objects but does it matter that these tasks do not mirror natural challenges?

"Tasks do not need to be 'naturalistic', by resembling a tree or a fruit, to be effective," says Ms Clark.

"Research suggests that in terms of animal welfare, it's more important for tasks to be motivating and 'functional' rather than looking natural."

Joystick games

We share 97% of our DNA with orangutans and 99% with chimpanzees so it is perhaps unsurprising that we have common interests.

But it is not just the great apes getting in on the interaction.

Professor John David Smith, from State University of New York at Buffalo and Michael Beran, from Georgia State University have trained macaque monkeys to use a joystick-based computer game.

When uncertain of the correct answer, macaques choose to skip the question and continue the game

To indicate whether the density of a pixel box that appeared at the top of the screen was either sparse or dense the monkeys had to simply move the cursor towards a letter S or a letter D.

"Rhesus monkeys can be trained to use joysticks to complete a variety of computer 'games' or tasks, and the animals readily and freely engage with these tasks for many hours of the day," explains Dr Beran.

"A number of studies suggest that the monkeys come to prefer having the computer apparatus available, to not having it available, even when the alternative is free food."

For Dr Beran, the computer games do not just enrich the lives of the monkeys, they can offer other important insights.

"In our lab perhaps the clearest indicator to us of impending illness or psychological distress in a monkey is a drop in his performance or in his production on his computer games," he explains.

Professor Smith adds: "In a sense, I think, the tasks are their 'Sudoku'.

"I have the impression that our tasks are appropriate and positive aspects of our animals' lives."

As advances in technology improve our lives they are also providing opportunities for us to learn more about our primate cousins, and enrich the experiences of those we study.

Ayumu the chimp features in Super Smart Animals on Wednesday 8 February, 20:00 GMT on BBC One.

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Saturday, February 4, 2012

Thursday, February 2, 2012

Science meets art in annual contest

In pictures: Science meets art in annual contest

Wednesday, February 1, 2012

Pakistan helping Afghan Taliban - Nato

Pakistan helping Afghan Taliban - Nato

Front page of the report
The report comes at a sensitive time in Pakistan-Nato relations

The Taliban in Afghanistan are being directly assisted by Pakistani security services, according to a secret Nato report seen by the BBC.

The leaked report, derived from thousands of interrogations, claims the Taliban remain defiant and have wide support among the Afghan people.

A BBC correspondent says the report is painful reading for international forces and the Afghan government.

A Pakistani foreign ministry spokesman called the accusations "ridiculous".

"We are committed to non-interference in Afghanistan and expect all other states to strictly adhere to this principle," Abdul Basit told the BBC.

"A stable and peaceful Afghanistan is in our own interests. We cannot indulge in any activity which takes us away from achieving that objective," he added.

The report alleges that Pakistan knows the locations of senior Taliban leaders.

"We have long been concerned about ties between elements of the ISI [Pakistan's intelligence service] and some extremist networks," said US Pentagon spokesman Captain John Kirby, adding that the US Defence Department had not yet seen the report.

Pakistan Foreign Minister Hina Rabbani Khar is currently in Kabul for talks with Afghan President Hamid Karzai.

'Informational'

“Start Quote

The Taliban are not Islam - the Taliban are Islamabad”

Senior al-Qaeda detainee, quoted by the report

The BBC's Quentin Sommerville in Kabul says the report - on the state of the Taliban - fully exposes for the first time the relationship between the ISI and the Taliban.

The report is based on material from 27,000 interrogations with more than 4,000 captured Taliban, al-Qaeda and other foreign fighters and civilians.

It notes: "Pakistan's manipulation of the Taliban senior leadership continues unabatedly".

It says that Pakistan is aware of the locations of senior Taliban leaders.

Analysis

Pakistan is finding it harder to convince outsiders it is not helping the Afghan Taliban and giving safe haven to its leaders.

In effect, the accusation is that Pakistan is betting on the insurgents being the strongest power in Afghanistan and most likely ally once Nato leaves - something Islamabad of course strenuously denies.

The leak of this report comes at a particularly sensitive time. Pakistan is already blocking the supply route to coalition forces in Afghanistan, following a Nato attack in which 24 Pakistani soldiers were killed.

With increasing pressure being heaped on Pakistan, public support here for formally ending co-operation with the West simply grows.

"Senior Taliban representatives, such as Nasiruddin Haqqani, maintain residences in the immediate vicinity of ISI headquarters in Islamabad," it said.

It quotes a senior al-Qaeda detainee as saying: "Pakistan knows everything. They control everything. I can't [expletive] on a tree in Kunar without them watching."

"The Taliban are not Islam. The Taliban are Islamabad."

Our correspondent says the report seems to suggest that the Taliban feel trapped by ISI control and fear they will never escape its influence.

However, it states: "As this document is derived directly from insurgents it should be considered informational and not necessarily analytical."

Despite Nato's strategy to secure the country with Afghan forces, the secret document details widespread collaboration between the insurgents and Afghan police and military.

Lt Col Jimmie Cummings, a spokesman for Nato's International Security Assistance Force (Isaf) in Afghanistan, said the document was "a classified internal document that is not meant to be released to the public".

"It is a matter of policy that documents that are classified are not discussed under any circumstances," he said.

The report also depicts the depth of continuing support among the Afghan population for the Taliban, our correspondent says.

It paints a picture of al-Qaeda's influence diminishing but the Taliban's influence increasing, he adds.

Taliban influence
Taliban fighters (file image) Villagers often prefer the Taliban to "corrupt" Afghan authorities, the report alleges

In a damning conclusion, the document says that in the last year there has been unprecedented interest, even from members of the Afghan government, in joining the Taliban cause.

It adds: "Afghan civilians frequently prefer Taliban governance over the Afghan government, usually as a result of government corruption."

The report has evidence that the Taliban are purposely hastening Nato's withdrawal by deliberately reducing their attacks in some areas and then initiating a comprehensive hearts-and-minds campaign.

It says that in areas where Isaf has withdrawn, Taliban influence has increased, often with little or no resistance from government security forces. And in many cases, with the active help of the Afghan police and army.

When foreign soldiers leave, Afghan security forces are expected to take control.

The report says that surrender is far from their collective mindset.

"For the moment, they believe that continuing the fight and expanding Taliban governance are their only viable courses of action," it adds.

According to the report, rifles, pistols and heavy weapons have been sold by Afghan security forces in bazaars in Pakistan.

The report adds that Taliban members "do not receive salaries or other financial incentives for their work", but their operations are funded by the narcotics trade and they frequently take a cut from the trade.

Their main revenue, though, is from donations, and they travel around the country from door to door making no secret of their affliation, it says.

Follow BBC Kabul correspondent Quentin Sommerville on Twitter @mrsommerville

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Tuesday, January 31, 2012

Skin transformed into brain cells

Skin transformed into brain cells

Neural network

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Skin cells have been converted directly into cells which develop into the main components of the brain, by researchers studying mice in California.

The experiment, reported in Proceedings of the National Academy of Sciences, skipped the middle "stem cell" stage in the process.

The researchers said they were "thrilled" at the potential medical uses.

Far more tests are needed before the technique could be used on human skin.

Stem cells, which can become any other specialist type of cell from brain to bone, are thought to have huge promise in a range of treatments. Many trials are taking place, such as in stroke patients or specific forms of blindness.

One of the big questions for the field is where to get the cells from. There are ethical concerns around embryonic stem cells and patients would need to take immunosuppressant drugs as any stem cell tissue would not match their own.

An alternative method has been to take skin cells and reprogram them into "induced" stem cells. These could be made from a patient's own cells and then turned into the cell type required, however, the process results in cancer-causing genes being activated.

“Start Quote

We are thrilled about the prospects for potential medical use of these cells”

Prof Marius Wernig Stanford University School of Medicine
Direct approach

The research group, at the Stanford University School of Medicine in California, is looking at another option - converting a person's own skin cells into specialist cells, without creating "induced" stem cells. It has already transformed skin cells directly into neurons.

This study created "neural precursor" cells, which can develop into three types of brain cell: neurons, astrocytes and oligodendrocytes.

These precursor cells have the advantage that, once created, they can be grown in a laboratory into very large numbers. This could be critical if the cells were to be used in any therapy.

Brain cells and skin cells contain the same genetic information, however, the genetic code is interpreted differently in each. This is controlled by "transcription factors".

The scientists used a virus to infect skin cells with three transcription factors known to be at high levels in neural precursor cells.

After three weeks about one in 10 of the cells became neural precursor cells.

Lead researcher Prof Marius Wernig said: "We are thrilled about the prospects for potential medical use of these cells.

"We've shown the cells can integrate into a mouse brain and produce a missing protein important for the conduction of electrical signal by the neurons.

"More work needs to be done to generate similar cells from human skin cells and assess their safety and efficacy."

Dr Deepak Srivastava, who has researched converting cells into heart muscle, said the study: "Opens the door to consider new ways to regenerate damaged neurons using cells surrounding the area of injury."

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