Showing posts with label Technology. Show all posts
Showing posts with label Technology. Show all posts

Saturday, January 5, 2013

Immune system 'booster' may hit cancer


Immune system 'booster' may hit cancer

Two T-cells on the surface of a cancerous cell Two white blood cells attacking a cancer

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Vast numbers of cells that can attack cancer and HIV have been grown in the lab, and could potentially be used to fight disease.
The cells naturally occur in small numbers, but it is hoped injecting huge quantities back into a patient could turbo-charge the immune system.
The Japanese research is published in the journal Cell Stem Cell.
Experts said the results had exciting potential, but any therapy would need to be shown to be safe.
The researchers concentrated on a type of white blood cell known as a cytotoxic T-cell, which can recognise telltale markings of infection or cancer on the surfaces of cells. If a marking is recognised, it launches an attack.
Teams at the University of Tokyo and the Riken Research Centre for Allergy and Immunology used advances in stem cell technology to make more T-cells.
One group extracted T-cells which targeted a patient's skin cancer. Another group did the same for HIV.

“Start Quote

The next step will be to test whether these T-cells can selectively kill tumour cells, but not other cells in the body”
Dr Hiroshi Kawamoto Researcher
These T-cells were converted into stem cells, which could dramatically increase in number when grown in the laboratory. These were converted back into T-cells which should also have the ability to target the cancer or HIV.
New weapon? The groups have proved only that they can make these cells, not that they can be safely put back into patients or that if would make a difference to their disease if they did.
Dr Hiroshi Kawamoto, who worked on the cancer immune cells at Riken, said: "The next step will be to test whether these T-cells can selectively kill tumour cells, but not other cells in the body.
"If they do, these cells might be directly injected into patients for therapy. This could be realized in the not-so-distant future."
Dr Hiromitsu Nakauchi from the University of Tokyo said it was "unclear" whether this technique would help in treating HIV and that other infections and cancer may be a better place to start.
'Very exciting' Experts in the field said the findings were encouraging.
Prof Alan Clarke, the director of the European Cancer Stem Cell Research Institute at Cardiff University, said: "This is a potentially very exciting development which extends our capacity to develop novel cell therapies."
He said it was important that cells could be tailored for each patient so there would be no risk of rejection.
Other experts said the findings were still at an early stage, but were still very promising and represented a strong foundation for future research. However, Cancer Research UK said it was still too early to know if any therapy would be safe.
Prof Sir John Burn, from the Institute of Genetic Medicine at Newcastle University, said: "This is a very appealing concept and the research team are to be congratulated on demonstrating the feasibility of expanding these killer cells.
However he added: "Even if these T cells are effective, it could prove very challenging to produce large quantities safely and economically.
"Nevertheless, there is real promise of this becoming an alternative when conventional therapies have failed."

Source

Monday, December 3, 2012

Plastic bulb development promises better quality light


Plastic bulb development promises better quality light

Wake forest university researchers

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US researchers say they have developed a new type of lighting that could replace fluorescent bulbs.
The new source is made from layers of plastic and is said to be more efficient while producing a better quality of flicker-free light.
The scientists behind it say they believe the first units will be produced in 2013.
Details of the new development have been published in the journal Organic Electronics.

“Start Quote

What we've found is a way of creating light rather than heat”
Prof David Carroll Wake Forest University
Brighter white
The new light source is called field-induced polymer electroluminescent (Fipel) technology. It is made from three layers of white-emitting polymer that contain a small volume of nanomaterials that glow when electric current is passed through them.
The inventor of the device is Dr David Carroll, professor of physics at Wake Forest University in North Carolina. He says the new plastic lighting source can be made into any shape, and it produces a better quality of light than compact fluorescent bulbs which have become very popular in recent years.
Wake university researcher with light The new light source is said to be twice as efficient as fluorescent bulbs
"They have a bluish, harsh tint to them, " he told BBC News, "it is not really accommodating to the human eye; people complain of headaches and the reason is the spectral content of that light doesn't match the Sun - our device can match the solar spectrum perfectly.
"I'm saying we are brighter than one of these curly cube bulbs and I can give you any tint to that white light that you want."

Lighting up the world

  • Lighting accounts for around 19% of global electricity use
  • A worldwide switch to low-energy bulbs could save the output of around 600 power plants
There have been several attempts to develop new light-bulbs in recent years - Light Emitting Diodes (LEDs) have come a long way since they were best known for being indicator lights in electronic devices. Over the past decade, they have become much more widely used as a light source as they are both bright and efficient. They are now often used on large buildings.
Light not heat Another step forward has been organic LEDs (OLEDs) which also promise greater efficiency and better light than older, incandescent bulbs. Their big advantage over LEDs is that they can be transformed into many different shapes including the screens for high-definition televisions.
But Prof Carroll believes OLED lights haven't lived up to the hype.
"They don't last very long and they're not very bright," he said. "There's a limit to how much brightness you can get out of them. If you run too much current through them they melt."
The Fipel bulb, he says, overcomes all these problems.
"What we've found is a way of creating light rather than heat. Our devices contain no mercury, they contain no caustic chemicals and they don't break as they are not made of glass."
Prof Carroll says his new bulb is cheap to make and he has a "corporate partner" interested in manufacturing the device. He believes the first production runs will take place in 2013.
He also has great faith in the ability of the new bulbs to last. He says he has one in his lab that has been working for about a decade.

Source 

Friday, November 30, 2012

Bread that lasts for 60 days could cut food waste


Bread that lasts for 60 days could cut food waste


Bread

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An American company has developed a technique that it says can make bread stay mould-free for 60 days.
The bread is zapped in a sophisticated microwave array which kills the spores that cause the problem.
The company claims it could significantly reduce the amount of wasted bread - in the UK alone, almost a third of loaves purchased.
The technique can also be used with a wide range of foods including fresh turkey and many fruits and vegetables.
World of waste Food waste is a massive problem in most developed countries. In the US, figures released this year suggest that the average American family throws away 40% of the food they purchase - which adds up to $165bn (£102bn) annually.
Bread is a major culprit, with 32% of loaves purchased in the UK thrown out as waste when they could be eaten, according to figures from the Department for Environment, Food and Rural Affairs (Defra).
Machine microwave The machine uses similar technology to a home microwave
One of the biggest threats to bread is mould. As loaves are usually wrapped in plastic, any water in the bread that evaporates from within is trapped and makes the surface moist. This provides excellent growing conditions for Rhizopus stolonifer, the fungus that leads to mould.
In normal conditions, bread will go mouldy in around 10 days.
But an American company called Microzap says it has developed a technique that will keep the bread mould free for two months.
At its laboratory on the campus of Texas Tech University in Lubbock, chief executive Don Stull showed off the long, metallic microwave device that resembles an industrial production line. Originally designed to kill bacteria such as MRSA and salmonella, the researchers discovered it could kill the mould spores in bread in around 10 seconds.
"We treated a slice of bread in the device, we then checked the mould that was in that bread over time against a control, " he explained.
"And at 60 days it had the same mould content as it had when it came out of the oven."
Question of taste The machine the team has built uses much the same technology as found in commercial microwaves - but with some important differences, according to Mr Stull.
"We introduce the microwave frequencies in different ways, through a slotted radiator. We get a basically homogeneous signal density in our chamber - in other words, we don't get the hot and cold spots you get in your home microwave."

20th-Century history of bread

Bread making competition 1965
  • 1928: First bread slicing machine, invented by Otto Rohwedder, exhibited in US
  • 1930: Large UK bakeries take commercial slicers and sliced bread first appears in shops
  • 1933: About 80% of US bread is pre-sliced and wrapped, and the phrase "the best thing since sliced bread" is coined
  • 1941: Calcium added to UK flour to prevent rickets
  • 1942: The national loaf - much like today's brown loaf - introduced to combat shortage of white flour
  • 1954: Conditions in bakeries regulated by the Night Baking Act
  • 1956: National loaf abolished
  • 1961: The Chorleywood Bread Process introduced
Source: The Federation of Bakers
The company's device has attracted plenty of interest from bread manufacturers - but it is worried that it could push up costs in an industry where margins are very tight.
And there is also a concern that consumers might not take to bread that lasts for so long. Mr Stull acknowledges it might be difficult to convince some people of the benefits.
"We'll have to get some consumer acceptance of that," he said. "Most people do it by feel and if you still have that quality feel they probably will accept it. "
Mr Stull believes that the technology could impact bread in other ways. He said that bread manufacturers added lots of preservatives to try and fight mould, but then must add extra chemicals to mask the taste of the preservatives. If bakers were able to use the microwave technology, they would be able to avoid these additives.
While a wholesale change in the bread industry might be difficult to achieve, there may be more potential with other foods, including ground turkey.
In 2011, food giant Cargill had to recall 16 million kg of the product after a salmonella outbreak. Mr Stull believes that using microwaves would be an effective way of treating this and several other products ranging from jalapenos to pet foods.
The only fruit that his device was unable to treat effectively were cantaloupes.
"We've used our tumbler machine to treat them, he says "but you can't tumble cantaloupes because they damage."

Source

Thursday, November 22, 2012

South Pacific Sandy Island 'proven not to exist'


South Pacific Sandy Island 'proven not to exist'

Sandy Island map Cartographers everywhere are now rushing to undiscover Sandy Island for ever

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A South Pacific island, shown on marine charts and world maps as well as on Google Earth and Google Maps, does not exist, Australian scientists say.
The supposedly sizeable strip of land, named Sandy Island on Google maps, was positioned midway between Australia and French-governed New Caledonia.
But when scientists from the University of Sydney went to the area, they found only the blue ocean of the Coral Sea.
The phantom island has featured in publications for at least a decade.
Scientist Maria Seton, who was on the ship, said that the team was expecting land, not 1,400m (4,620ft) of deep ocean.
"We wanted to check it out because the navigation charts on board the ship showed a water depth of 1,400m in that area - very deep," Dr Seton, from the University of Sydney, told the AFP news agency after the 25-day voyage.
"It's on Google Earth and other maps so we went to check and there was no island. We're really puzzled. It's quite bizarre.
"How did it find its way onto the maps? We just don't know, but we plan to follow up and find out."
Australian newspapers have reported that the invisible island would sit within French territorial waters if it existed - but does not feature on French government maps.
Australia's Hydrographic Service, which produces the country's nautical charts, says its appearance on some scientific maps and Google Earth could just be the result of human error, repeated down the years.
A spokesman from the service told Australian newspapers that while some map makers intentionally include phantom streets to prevent copyright infringements, that was was not usually the case with nautical charts because it would reduce confidence in them.
A spokesman for Google said they consult a variety of authoritative sources when making their maps.
"The world is a constantly changing place, the Google spokesman told AFP, "and keeping on top of these changes is a never-ending endeavour'.'
The BBC's Duncan Kennedy in Sydney says that while most explorers dream of discovering uncharted territory, the Australian team appears to have done the opposite - and cartographers everywhere are now rushing to undiscover Sandy Island for ever.

Source 

Monday, November 19, 2012

Anonymous message to pro-Israeli groups


Greetings from Anonymous,

It has come to our attention that conservative and pro-Israeli groups throughout the blogosphere have taken advantage of Operation Israel, attempting to solidify public opinion against Anonymous.

TheOtherMcCain.com posted an editorial this morning which stated the following: “If you ever doubted that Anonymous was a terrorist organization, they have now removed all reason for doubt.” The article only contained 55 words of original content by the site itself, the other 90 percent of the article was selected quotations by mainstream media sources.

Let us once again be perfectly clear: Anonymous does not in any way support the use of violence. Anonymous is a world wide collective of individuals whose means pursue human rights, justice, and universal equality for the citizens of every nation.

Pro-Israeli groups throughout the world have grown from a foundation of Israeli/US propaganda and lies.
They arbitrarily dismiss the apartheid system of racial segregation and oppression imposed by the Israeli government on the Palestinian people. The fact of the matter is, in the eyes of the media, only the United States and it’s allies are capable of labeling another state or organization as a terrorists. Throughout our campaign, we’ve been inundated with one response in particular; references to Hamas hiding in school buildings or using women and children as human shields. Selective memory seems to have given pro-Israeli organizations the ability to forget that in 2005 Israeli Defence Minister Shaul Mofaz appeared in court to defend the practice of using Palestinians as human shields in combat after a supreme court outlawed the practice, noting it violated International Law.

The reasons for Anonymous intervention through #OpIsrael should be abundantly clear: What is happening in Palestine is oppression. They have no navy, no army, or air force. There is no war in Gaza. There is only the continuous application of military force by Israel in an attempt to push every last person out of the Palestinian state, despite international laws that make these efforts illegal. This illegal expansion of territory by Israel in to the Palestinian state has been ongoing since1948, making refugees of over 700,000 Palestinians. Today, 
Palestinians are not permitted to live in Israeli settlements, drive on Israeli roads or even travel is the “security” areas surrounding them. These Israeli only housing developments are being built on stolen land, even while being called illegal settlements by the International Court of Justice.

The violence inflicted upon the civilian residents of Gaza is well documented, despite the fact that Israel has adamantly opposed intervention by human rights organizations and the IDF constantly blocks and harasses international journalists.

Despite these facts, Anonymous has not used any anti-Semitic language during our campaign. Nor have we vocalized any support for Palestinian military operations or resistance groups. Our goal was to protect the rights of Palestinian people who are threatened with silence as Israel has made attempts to shut down cell phone and internet service throughout Gaza. We know what happens to victims of oppression when the lights go dark.

It is also worthy to note, that as of yesterday, members of Anonymous participating in #OpIsrael were making attempts to augment our Gaza Care Package for civilians in Tel Aviv by translating the same documents in to Hebrew in the event that they lose access to internet service as well. We do not racially or geographically differentiate between victims of violence or oppression anywhere in the world.

Both Palestinians and Israelis need to find common ground and end the violence that has already resulted in the deaths of innocent people, including children. Israel’s advancement on Palestinian Territories and the racist oppression of Palestinian people needs to end.

We are not terrorists. Governments that fund wars, practice deceit against their own citizens, condone corruption, and turn a blind eye to the deaths of innocent people are terrorists. The word terror does not belong to Israel or the United States. We will judge you by your actions.
Peace and Freedom to all,
#OpIsrael
#Anonymous
Anonymous Gaza Care Package
#OpIsrael Information and Tools
Original PR source

Source

Monday, November 12, 2012

Vegetative patient Scott Routley says 'I'm not in pain'


Vegetative patient Scott Routley says 'I'm not in pain'



Scott Routley

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A Canadian man who was believed to have been in a vegetative state for more than a decade, has been able to tell scientists that he is not in any pain.
It's the first time an uncommunicative, severely brain-injured patient has been able to give answers clinically relevant to their care.
Scott Routley, 39, was asked questions while having his brain activity scanned in an fMRI machine.
His doctor says the discovery means medical textbooks will need rewriting.
Vegetative patients emerge from a coma into a condition where they have periods awake, with their eyes open, but have no perception of themselves or the outside world.
Mr Routley suffered a severe brain injury in a car accident 12 years ago.
None of his physical assessments since then have shown any sign of awareness, or ability to communicate.
But the British neuroscientist Prof Adrian Owen - who led the team at the Brain and Mind Institute, University of Western Ontario - said Mr Routley was clearly not vegetative.

Panorama: Find out more

  • Fergus Walsh presents The Mind Reader: Unlocking My Voice - a Panorama Special
  • BBC One, Tuesday 13 November at 22:35 GMT
"Scott has been able to show he has a conscious, thinking mind. We have scanned him several times and his pattern of brain activity shows he is clearly choosing to answer our questions. We believe he knows who and where he is."
Prof Owen said it was a groundbreaking moment.
"Asking a patient something important to them has been our aim for many years. In future we could ask what we could do to improve their quality of life. It could be simple things like the entertainment we provide or the times of day they are washed and fed."
Scott Routley's parents say they always thought he was conscious and could communicate by lifting a thumb or moving his eyes. But this has never been accepted by medical staff.
Prof Bryan Young at University Hospital, London - Mr Routley's neurologist for a decade - said the scan results overturned all the behavioural assessments that had been made over the years.

FMRI SCANNING

Prof Adrian Owen and team with patient at scanner
  • Functional Magnetic Resonance Imaging measures the real-time activity of the brain by tracking the flow of oxygen-rich blood
  • The patients were repeatedly asked to imagine playing tennis or walking around their home
  • In healthy volunteers each produces a distinct pattern of activity, in the premotor cortex for the first task and the parahippocampal gyrus for the second
  • It allowed the researchers to put a series of yes or no questions to severely brain-injured patients. A minority were able to answer by using the power of thought
  • In 2010 Prof Owen published research showing that nearly one in five of the vegetative patients were able to communicate using brain activity
"I was impressed and amazed that he was able to show these cognitive responses. He had the clinical picture of a typical vegetative patient and showed no spontaneous movements that looked meaningful."
Observational assessments of Mr Routley since he responded in the scanner have continued to suggest he is vegetative. Prof Young said medical textbooks would need to be updated to include Prof Owen's techniques.
The BBC's Panorama programme followed several vegetative and minimally-conscious patients in Britain and Canada for more than a year.
Another Canadian patient, Steven Graham, was able to demonstrate that he had laid down new memories since his brain injury. Mr Graham answers yes when asked whether his sister has a daughter. His niece was born after his car accident five years ago.
The Panorama team also followed three patients at the Royal Hospital for Neuro-disability (RHN) in Putney, which specialises in the rehabilitation of brain-injured patients.
It collaborates with a team of Cambridge University neuroscientists at the Wolfson Brain Imaging Centre at Addenbrooke's hospital, Cambridge.
Panorama's Fergus Walsh meets Professor Adrian Owen to learn what the brain is like when in a vegetative state
One of the patients is diagnosed as vegetative by the RHN, and he is also unable to show awareness in an fMRI machine.
A second patient, who had not been fully assessed by the RHN, is shown to have some limited awareness in brain scans.
The Mind Reader: Unlocking My Voice - a Panorama Special - will be broadcast on Tuesday 13 November at 22:35 on BBC One. Or catch up later on the BBC iPlayer using the link above.

US to become 'world's biggest oil producer'


US to become 'world's biggest oil producer'

Oil fracking operation in North Dakota 
  Shale oil and gas is now big business in the US

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The US will overtake Saudi Arabia as the world's biggest oil producer "by around 2020", an International Energy Agency (IEA) report has said.
The IEA said the reason for this was the big growth and development in the US of extracting oil from shale rock.
This has enabled the US to gain significantly more extractable oil resources.
As a result, the IEA predicts the US will become "all but self-sufficient" in its energy needs by around 2035.
The US shale oil industry has grown significantly in recent years.
It extracts oil from the ground using a method called fracking - pumping down a mixture of sand, water and chemicals at high pressure.
The industry says the method is safe, but critics say it could cause earthquakes and pollute water sources.
The IEA predicts that the US will be producing 11.1 million barrels per day by 2020, compared with 10.6 million from Saudi Arabia.
Currently the US imports about 20% of its total energy needs.
The IEA also expects that the US will overtake Russia as the word's biggest gas producer by 2015, again thanks to fracking, which can also be used to extract natural gas.
It warns that the big growth in US oil and gas production could have significant geopolitical implications, as it may make the US less concerned about the Middle East.

Source

Tuesday, October 23, 2012

The maths that made Voyager possible


The maths that made Voyager possible

In 1961, mathematics graduate Michael Minovitch decided to take on the hardest problem in celestial mechanics - the "three body problem".

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Nasa's Voyager spacecraft have enthralled everyone with their exploits at the edge of the Solar System, but their launch in 1977 was only possible because of some clever maths and the persistence of a PhD student who worked out how to slingshot probes into deep space.
On the 3 October, 1942, the nose cone of an early V2 test rocket soared high above the north German coast before falling back to a crash-landing in the Baltic Sea.
For the first time in history, an object built by humans had crossed the invisible Karman line, which marks the edge of space.
Astonishingly, within 70 years - just one human lifespan - we'd hurled another spacecraft right to the edge of the Solar System.
Today, 35 years after leaving Earth, Voyager 1 is 18.4 billion km (11.4 billion miles) from Earth and about to cross over the boundary marking the extent of the Sun's influence, where the solar wind meets interstellar space.
Sometime in the next five years, it will likely break through this so called "bowshock" and head out into the galaxy beyond. Its twin, Voyager 2, having flown past all the outer giant planets, should pass over into interstellar not long after.

Nasa's Voyager probes

  • Voyager 2 launched on 20 August 1977; Voyager 1 lifted off on 5 September the same year
  • Their official missions were to study Jupiter and Saturn, but the probes were able to continue on
  • The Voyager 1 probe is now the furthest human-built object from Earth
  • Both probes carry discs with recordings designed to portray the diversity of culture on Earth
It's easy to take this monumental achievement for granted, but the gateway to the outer Solar System remained shut for the first 20 years of the space age.
In 1957, as Sputnik 1 became the first engineered object to orbit our home planet, mission planners started to look towards other worlds to propel their probes.
Spacecraft were quickly dispatched to the Moon, Venus and Mars. But there was one major limiting factor to reaching more distant destinations.
For a voyage to the outer planets, you must escape the gravitational pull of the Sun, and that demands a very large rocket indeed. And given what an "uphill" gravitational struggle it would be to reach them, such a journey to the furthest planet - Neptune, more than four billion km (2.5 billion miles) away - could easily take 30 or 40 years.
At the time, Nasa couldn't guarantee a spacecraft for more than a few months of operational life, and so the outer planets were considered out of reach.
That was until a 25-year-old mathematics graduate called Michael Minovitch came along in 1961.
Excited by UCLA's new IBM 7090 computer, the fastest on Earth at the time, Minovitch decided to take on the hardest problem in celestial mechanics: the "three body problem".
Jupiter, Nasa The issue was being able to reach the outer planets in practical timeframe
The three bodies it refers to are the Sun, a planet and a third object such as an asteroid or comet all travelling through space with their gravities acting on each other. The problem is predicting exactly how the gravity of the Sun and the planet will influence the third object's trajectory.
Astronomers had been pondering the three-body problem for at least 300 years, ever since they'd started plotting the path that comets took as they fell through the inner Solar System towards the Sun.
Undeterred by the fact that some of the finest minds in history, including Isaac Newton hadn't solved the three-body problem, Minovitch became focused on cracking it. He intended to use the IBM 7090 computer to home in on a solution using a method of iteration.
In his spare time, whilst studying for his PhD during the summer of 1961, he set about coding a series of equations to apply to the problem.
Feeding data on planetary orbits into his model, Minovitch had made progress by the autumn, but was anxious to check his data. So in the summer of the following year, during an internship at Nasa's Jet Propulsion Lab he persuaded his boss to give him more accurate data on planetary positions to re-test his model.
To his delight, he ran the simulations again and found his solution still worked. What he had achieved made possible an extraordinary breakthrough in spacecraft propulsion.
Minovitch had shown that as a craft flew close to a planet orbiting the Sun, it would steal some of the planet's orbital speed, and be accelerated away from the Sun. Such acceleration, without using a single drop of rocket propellant seemed too good to be true, and Minovitch's critics were quick to try to discredit him.
Voyager One, Nasa The domain of the Sun's influence is called the heliosphere: The Voyagers are approaching the edge of this enormous balloon of charged particles thrown out into space by our star
Without funds for further computer time, and in a bid to persuade Nasa to embrace his discovery, he drew up by hand hundreds of theoretical mission trajectories to the outer planets. Among them was one very special flight path that would become the Voyagers' trajectory.
But in 1962 the Jet Propulsion Lab was preoccupied with supporting Project Apollo, and no-one spotted Minovitch's breakthrough.
It would take another summer intern called Gary Flandro to identify the opportunity.
A spacecraft engineer, grounded in the hard realities of spaceflight, Flandro knew that any mission to the outer planets would have to be flown as fast as possible, otherwise the craft might not last long enough to reach its destination.
So in the summer of 1965, he began to look at whether the solution to the three-body problem could be put to practical use in exploring the outer planets. He started by drawing graphs of where these planets were going to be in the coming years.
And to his surprise, the plots revealed that Jupiter, Saturn, Uranus and Neptune would all be on the same side of the Solar System in the late 1970s.
Using a solution to the three-body problem, a single mission, launching from Earth in 1977, could sling a spacecraft past all four planets within 12 years. Such an opportunity would not present itself again for another 176 years.
With further lobbying from Minovitch and high level intervention from Maxwell Hunter, who advised the president on US space policy, Nasa eventually embraced Minovitch's slingshot propulsion and Flandro's idea for a "grand tour" of the planets.
IBM computer The solution came through using the most powerful computer of the day
Initially named "Mariner-Jupiter-Saturn", or MJS, funding to build two spacecraft was released in the early 1970s. The twin craft would eventually become known as the Voyagers.
To reach Neptune they would have to last for over a decade in space, operating in the darkest reaches of the Solar System billions of km from the Sun.
They would require radiation-hardened electronics to survive their encounters with the magnetosphere of Jupiter, and an artificial intelligence autonomous enough to make independent decisions when too far away from Earth for help.
Although still lacking funding to extend its mission beyond Saturn, Nasa's optimistic engineers loaded enough control propellant on board to keep the probes' dishes orientated towards the Earth for decades after passing Saturn.
They'd also built the Voyager power supply system to last until at least the year 2020. But most visionary of all, they'd included five experiments on board that were capable of analyzing space beyond the Solar System.
In 1977, as the duo launched from Earth, no-one dared imagine that they would survive long enough to make such measurements. But in 2012, they're still going strong - their pitifully weak signals just a billionth of a billionth of a billionth of a watt of power by the time they reach the Earth. New discoveries are still being made.
Today, in a darkened lecture theatre at JPL - named after the same Theodore von Karman whose boundary to space our machines first crossed 70 years ago - sits a model of the Voyagers.
These great machines are now carrying our spirit of exploration across a boundary the Hungarian-American engineer could only dream of - into interstellar space.
Chris Riley next to the Voyager model at JPL The author Christopher Riley stands in front of the Voyager exhibition at JPL

Friday, October 5, 2012

Exhibition gives visitors power to control the rain


Exhibition gives visitors power to control the rain

Rain Room exhibition 
  The Rain Room has been described as a "cocooning experience" by its creators.

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Most of us have been caught in a torrential downpour and wished we could make it stop, but how would it feel to have the power to control the weather?
Rain Room, a new 3D exhibition at London's Barbican Centre marries art, science and technology to do just that.
Despite standing in a space filled with drops of falling water, visitors remain dry, as the water halts above them.
Its creators have described it as "a social experiment" which "extracts behavioural experiences".
"We wanted to give people the cocooning experience of being immersed in a 3D rain room and watch their reaction," Hannes Koch told the BBC.
Koch met Florian Ortkrass and Briton Stuart Wood in 2005 while studying at the Royal College of Art in London and together they formed Random International.
As well as audience participation, science and technology play a big part in bringing their experimental exhibition to life.
Gravity effect With several 3D sensory cameras fixed to the ceiling of the Rain Room, every person who walks into the 100 square metre space is recognised.
Random International Florian Ortkrass, Stuart Wood and Hannes Koch met at London's Royal College of Art.
As they move around "slowly", the rain stops overhead.
"If you run around you'll get wet because while the sensor picks up the movement, gravity limits the speed of the drops falling from the ceiling," explained Koch.
The artists said he and collaborators hoped the experience would give people a sense of "playful empowerment".
"By your sheer presence you can control the rain."
The installation has been designed to create an intimate atmosphere of contemplation.
"There's no distractive sound, you are very close [to the rain] and it is beautiful as it becomes hypnotic and the sound of the rain is extremely calming.
"Behavioural experiences" "It is very different to having an umbrella as you don't have the sound of the rain battering on the umbrella," said Koch."
This is not Random International's first experiment with visitor participation.
Its 2008 exhibition, Audience, used motorised mirrors to respond to the individual facing them with each viewer becoming the subject of the exhibition.
"It has been interesting and a lot of fun for us to watch people, as this kind of installation piece extracts behavioural experiences," said Koch.
"In the Rain Room, shy people may wait to see others' reaction and may act quite cautiously, while more excitable visitors will just rush in."
If the Rain Room is filled with participants, the "collective power of the crowd stops the rain", which Koch admits may limit the experience.
"We have recommended to our hosts that a little crowd control may be required to give people the full experience."
Rain Room at The Curve runs until March next year.

Source 

Thursday, October 4, 2012

Life created from eggs made from skin cells


Life created from eggs made from skin cells

Newborn mice 
  The resulting mice were fully fertile

Stem cells made from skin have become "grandparents" after generations of life were created in experiments by scientists in Japan.
The cells were used to create eggs, which were fertilised to produce baby mice. These later had their own babies.
If the technique could be adapted for people, it could help infertile couples have children and even allow women to overcome the menopause.
But experts say many scientific and ethical hurdles must be overcome.
Healthy and fertile Stem cells are able to become any other type of cell in the body from blood to bone, nerves to skin.
Last year the team at Kyoto University managed to make viable sperm from stem cells. Now they have performed a similar feat with eggs.
They used stem cells from two sources: those collected from an embryo and skin-like cells which were reprogrammed into becoming stem cells.

“Start Quote

I just thought wow! The science is quite brilliant”
Dr Evelyn Telfer University of Edinburgh
The first step, reported in the journal Science, was to turn the stem cells into early versions of eggs.
A "reconstituted ovary" was then built by surrounding the early eggs with other types of supporting cells which are normally found in an ovary. This was transplanted into female mice.
Surrounding the eggs in this environment helped them to mature.
IVF techniques were used to collect the eggs, fertilise them with sperm from a male mouse and implant the fertilised egg into a surrogate mother.
Dr Katsuhiko Hayashi, from Kyoto University, told the BBC: "They develop to be healthy and fertile offspring."
Those babies then had babies of their own, whose "grandmother" was a cell in a laboratory dish.
Devastating blow The ultimate aim of the research is to help infertile couples have children. If the same methods could be used in people then cells in skin could be turned into an egg. Any resulting child would be genetically related to the mother.
However, Dr Hayashi said that was still a distant prospect: "I must say that it is impossible to adapt immediately this system to human stem cells, due to a number of not only scientific reasons, but also ethical reasons."
He said that the level of understanding of human egg development was still too limited. There would also be questions about the long-term consequences on the health of any resulting child.
Dr Evelyn Telfer, from the University of Edinburgh, said: "It's an absolutely brilliant paper - they made oocytes [eggs] from scratch and get live offspring. I just thought wow! The science is quite brilliant."
However, she warned that this had "no clinical relevance" as there were still too many gaps in understanding about how human eggs developed.
"If you can show it works in human cells it is like the Holy Grail of reproductive biology," she added.
Prof Robert Norman, from the University of Adelaide, said: "For many infertile couples, finding they have no sperm or eggs is a devastating blow.
"This paper offers light to those who want a child, who is genetically related to them, by using personalised stem cells to create eggs that can produce an offspring that appears to be healthy.
"It also offers the potential for women to have their own children well past menopause raising even more ethical issues.
"Application to humans is still a long way off, but for the first time the goal appears to be in sight."
Dr Allan Pacey, from the British Fertility Society and the University of Sheffield, said: "What is remarkable about this work is the fact that, although the process is still quite inefficient, the offspring appeared healthy and were themselves fertile as adults."

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'50-hour genome' test for babies with genetic diseases


'50-hour genome' test for babies with genetic diseases

Baby in intensive care 
  Faster results mean sick babies can be given the correct medication

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Doctors in the US say they have taken a big step forward in the speed of analysing the DNA of seriously ill babies with genetic diseases.
The whole of a baby's genetic code - genome - was sequenced, analysed and the results given to doctors within 50 hours in intensive care units at Children's Mercy Hospital, Kansas City.
The process would normally take at least a month, they said.
Experts in the UK said it was an "impressive" technical achievement.
US doctors say up to a third of babies admitted to neonatal intensive care units are there because of genetic diseases caused by mutations in their DNA. However, there are more than 3,500 different genetic diseases meaning many are rare and difficult to diagnose.
The first copy of the blueprint of human life - the Human Genome Project - took years to accomplish and an incredible amount of money. Since then both the time and the cost have fallen dramatically.
Children's Mercy Hospital has been testing a new way of reading the genetic code which takes 50 hours from the moment a blood sample is taken.
They were able to make a diagnosis in three out of the four babies they tested, according to a study published in Science Translational Medicine.
Costly business Dr Stephen Kingsmore, director of the Center for Pediatric Genomic Medicine at the hospital, said: "We can now consider whole genome sequencing to be relevant for hospital medicine.
"It is now feasible to decode an entire genome and provide interim results back to the physician in two days.
"We think this is going to transform the world of neonataology."
The results could help doctors provide the best treatment and counsel families. However, at a cost of about £8,400 ($13,500) it is still expensive.
Prof David Bonthron, from the University of Leeds, said: "It's pretty impressive technically, they're pushing the envelope of how fast you can turn this stuff around - two days is pretty fast."
He said speed was also vital in analysing the genes of a foetus still in the womb if abnormalities have been identified.
However, he added: "The speed issue is maybe a bit restricted in its applicability as other areas are not that time pressured. In outpatients a few days is not that important."

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Tuesday, October 2, 2012

Liquid air 'offers energy storage hope'


Liquid air 'offers energy storage hope'

Electricity pylon and wind turbines (Image: PA) 
  Renewable power generation, such as wind turbines, can produce electricity when it is not in demand

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Turning air into liquid may offer a solution to one of the great challenges in engineering - how to store energy.
The Institution of Mechanical Engineers says liquid air can compete with batteries and hydrogen to store excess energy generated from renewables.
IMechE says "wrong-time" electricity generated by wind farms at night can be used to chill air to a cryogenic state at a distant location.
When demand increases, the air can be warmed to drive a turbine.
Engineers say the process to produce "right-time" electricity can achieve an efficiency of up to 70%.
IMechE is holding a conference today to discuss new ideas on how using "cryo-power" can benefit the low-carbon economy.
The technology was originally developed by Peter Dearman, a garage inventor in Hertfordshire, to power vehicles.
A new firm, Highview Power Storage, was created to transfer Mr Dearman's technology to a system that can store energy to be used on the power grid.
The process, part-funded by the government, has now been trialled for two years at the back of a power station in Slough, Buckinghamshire.
More than hot air The results have attracted the admiration of IMechE officials.
Highview Power Storage site (Image: Highview Power Storage) The energy storage technology has been tested for two years at a power station
"I get half a dozen people a week trying to persuade me they have a brilliant invention," head of energy Tim Fox told BBC News.
"In this case, it is a very clever application that really does look like a potential solution to a really great challenge that faces us as we increase the amount of intermittent power from renewables."
Dr Fox urged the government to provide incentives in its forthcoming electricity legislation for firms to store energy on a commercial scale with this and other technologies.
IMechE says the simplicity and elegance of the Highview process is appealing, especially as it addresses not just the problem of storage but also the separate problem of waste industrial heat.
The process follows a number of stages:
  1. "Wrong-time electricity" is used to take in air, remove the CO2 and water vapour (these would freeze otherwise)
  2. the remaining air, mostly nitrogen, is chilled to -190C (-310F) and turns to liquid (changing the state of the air from gas to liquid is what stores the energy)
  3. the liquid air is held in a giant vacuum flask until it is needed
  4. when demand for power rises, the liquid is warmed to ambient temperature. As it vaporizes, it drives a turbine to produce electricity - no combustion is involved
IMechE says this process is only 25% efficient but it is massively improved by co-siting the cryo-generator next to an industrial plant or power station producing low-grade heat that is currently vented and being released into the atmosphere.
The heat can be used to boost the thermal expansion of the liquid air.
More energy is saved by taking the waste cool air when the air has finished chilling, and passing it through three tanks containing gravel.
The chilled gravel stores the coolness until it is needed to restart the air-chilling process.
Delivering durability Highview believes that, produced at scale, their kits could be up to 70% efficient, and IMechE agrees this figure is realistic.
"Batteries can get 80% efficiency so this isn't as good in that respect," explains Dr Fox.
"But we do not have a battery industry in the UK and we do have plenty of respected engineers to produce a technology like this.
"What's more, it uses standard industrial components - which reduces commercial risk; it will last for decades and it can be fixed with a spanner."
In the future, it is expected that batteries currently used in electric cars may play a part in household energy storage.
But Richard Smith, head of energy strategy for National Grid, told BBC News that other sorts of storage would be increasingly important in coming decades and should be incentivised to commercial scale by government.
He said: "Storage is one of four tools we have to balance supply and demand, including thermal flexing (switching on and off gas-fired power stations); interconnections, and demand-side management. Ultimately it will be down to economics."
Mr Dearman, who also invented the MicroVent resuscitation device used in ambulances, told BBC News he was delighted at the success of his ideas.
He said he believed his liquid air engine would prevail against other storage technologies because it did not rely on potentially scarce materials for batteries. "I have been working on this off and on for close on 50 years," he told BBC News.
"I started when I was a teenager because I thought there wouldn't be enough raw materials in the world for everyone to have a car. There had to be a different way. Then somehow I came up with the idea of storing energy in cold.
"It's hard to put into words to see what's happening with my ideas today."
John Scott, from the Institution of Engineering and Technology (IET), added: "At present, pumped-hydro storage is the only practical bulk storage medium in the British grid.
"However, locations are very restricted," he told BBC News. "In the future, if new storage technologies can be deployed at a lower cost than alternatives, it would benefit the power system."
A spokesman for the Department of Energy and Climate Change (Decc) said it would shortly launch a scheme to incentivise innovation in energy storage. Other grants are available from Ofgem.
Follow Roger Harrabin on Twitter: @RogerHarrabin

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Wednesday, September 12, 2012

Viewpoint: Apple's iPhone launches no longer excite


Viewpoint: Apple's iPhone launches no longer excite


Apple unveils the latest version of its iPhone this Wednesday. It will be the first since the death of Steve Jobs.
To mark the occasion the BBC asked Dan Lyons, Newsweek magazine's technology editor and creator of the satirical blog, The Secret Diary of Steve Jobs, to pen an article about the firm's progress over past year.
This is his provocative view.
Man uses iPhone in front of Apple logo
Somewhere up there, I can hear Steve screaming

Back in 2006 I launched a blog where I pretended to be Apple CEO Steve Jobs. My alter ego, "Fake Steve," had a good run, but I shut it down in January 2011 when it became apparent that Jobs was in poor health. Nevertheless, even now, I'm constantly wondering what Steve would think about whatever Apple is doing.
This week it's the the iPhone 5. Everyone pretty much accepts that Apple will introduce it, and there have been so many leaks that everybody pretty much seems to know what it's going to be. Word is it will look a lot like the last two versions of the iPhone, except a bit thinner and a bit taller, with upgraded guts and a refreshed operating system.
iPhone and Galaxy S3 being held Samsung's Galaxy S3 is outselling the iPhone 4S in some countries
If that's correct, I imagine Steve is not happy. First of all, he'd be furious about the leaks. Steve liked surprising people.
More important, is this really the best we can expect from an outfit that claims to be the most innovative company in the world? This is the sixth version of the iPhone, and the user interface still looks almost exactly like the original iPhone in 2007.
The hardware on the iPhone has been the same for two years, since the iPhone 4 and 4S were virtually identical.
Now, having had two years to plot and scheme, Apple's renowned designer Jonathan Ive has replaced the tiny 3.5in (8.9cm) screen with a slightly-less-tiny 4in (10.2cm) screen? Wow. Knock me over with a feather. What do you do with the rest of your time, Jony?
This is what happens when a company is too cheap to invest in research and development. Did you know that Apple spends far less on R&D than any of its rivals - a paltry 2% of revenues, versus 14% for Google and Microsoft?
No wonder the Android platform, where new models appear every week, now represents 68% of the smartphone market, up from 47% a year ago, while Apple slid to 17% over the same period.
In case you're bad at math, let me work that out for you: Android's market share is now four times that of Apple. Four times!
Worse, despite all its bluster about innovation, Apple has become a copycat, and not even a good one. Why is Apple making the iPhone bigger? To keep up with the top Android phones.
Tim Cook launching the iPhone 4S Apple's stock has hit new heights under chief executive Tim Cook
(Phones that, mind you, Apple fanboys ridiculed at first.)
The problem is that the new iPhone won't really give you much more screen real estate than the old one. Worse, it looks ridiculous.
Apple also has become a copycat in tablets. Jobs once said the iPad's 9.7in screen was the perfect size, and smaller tablets made no sense. Then the Android camp had success with 7in tablets like Amazon's Kindle Fire and Google's Nexus 7, and now Apple supposedly will announce its own smaller iPad in October. Talk about thinking different!
What else is there to complain about?
Um, Siri still doesn't work. The oft-rumoured Apple TV doesn't exist yet, presumably because media companies won't let Apple take over their business.
The latest batch of Apple ads were such embarrassing garbage that Apple to take them down from YouTube. Apple's new guy in charge of retail launched a plan to lay off workers and boost profits, then had to walk it back when people pointed out that this was stupid.
The big $1bn (£650m) patent "victory" over Samsung made Apple look like a bully, and also raised awareness of how good Samsung's latest products are.
Last month, Samsung's Galaxy S3, with its huge 4.8in screen, outsold the iPhone 4S in the United States, the first time any smartphone has outsold the iPhone in the States.
Apple got where it was by taking bold risks. Now it has become a company that copies others and plays it safe.
A company that once was run by a product visionary now is run by a number-cruncher - chief executive Tim Cook, whose claim to fame involves running an efficient supply chain and beating ever lower prices out of Asian subcontractors and component suppliers.
To use a car analogy, six years ago the iPhone was like a sexy new flagship model from BMW or Porsche. Today it's a Toyota Camry. Safe, reliable, boring. The car your mom drives. The car that's so popular that its maker doesn't dare mess with the formula.
Person takes photo of Steve Jobs portrait Steve Jobs co-founded Apple in 1976. He stepped down as chief executive in August, 2011.
Apple seems less interested in blowing people away than it is in milking profit out of the existing lineup. At this Cook is doing marvellously well.
Sales are booming and will top $150bn this year, with net profit margins of nearly 30%. That's incredible in any business, but qualifies as a miracle when you're selling consumer electronics hardware.
Apple has more than $100bn in cash. Its market value of $632bn makes it the biggest company in the world, bigger than any company in US history.
That's great for Apple's shareholders. But for customers, who cares? In terms of products, Apple has become the one thing it should never be. Apple has become boring.
Somewhere up there, I can hear Steve screaming.

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Thursday, July 19, 2012

Microsoft makes its first ever loss

Microsoft makes its first ever loss

Microsoft logo  
Microsoft 's advertising business struggled to compete with rival Google

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The computing giant Microsoft has made its first-ever quarterly loss after it wrote off some of the value of its online advertising business.
The loss came after it wrote down the value of Aquantive by $6.2bn (£3.94bn, 5bn euros), which failed to bring the profits expected by Microsoft.
That led to a $492m loss in the three months to the end of June, compared with a profit of $5.9bn a year ago.
The company has not made a loss since it joined the stock market in 1986.
It took over aQuantive in 2007 but it struggled to compete with rival Google.
Microsoft paid $6.3bn for Aquantive.
Microsoft is doing well in other areas, despite the decline in popularity of its Windows operating system, which dominated the personal computer market for years.
Revenue for the three months to June rose by 4% to $18.06bn.
Mosaic Excluding the adjustment for the asset write-down, and the holding back of some income related to the launch of its Windows 8 system, Microsoft profits beat those expected by investors.
Shares were up 1.6% after the results were announced.
Microsoft says the update of the Windows systems is the most important redesign in more than 10 years.
Windows 8, which will launch in October, will feature a new look that will present applications in a mosaic of tiles.
Importantly, it will also enable the operating system to work on tablet computers, which along with smartphones are the fastest-growing sector of the computing market.
Microsoft is also planning to release its own tablet, the Surface.
Earlier this week, Microsoft previewed its next version of the Office system, which is expected to be released next year.

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Thursday, March 8, 2012

Touch-and-go tablet and computer screens

Touch-and-go tablet and computer screens

(Copyright: Getty Images)

(Copyright: Getty Images)

The new iPad launched yesterday amid its usual fanfare. But could dwindling supplies of a crucial component make such events a thing of the past?

Another iPad launch, another event filled with intense anticipation and speculation. This time Apple’s CEO Tim Cook revealed that the latest iteration of iPad will feature a high-definition screen, and no doubt its competitors will rapidly follow suit.

But there is a problem looming on the horizon for fans of the latest tablet computers, not to mention smart phones and flatscreen TVs. Whether it is on the shiny new iPad, computer or phone, the chances are that you are reading this article through a screen laced with one of the rarest metals on Earth: indium. And analysts are warning that global supplies of indium could be exhausted as soon as 2017. So how will we live without the gadgets that we have come to depend on?

Such a prospect might not seem as alarming as running out of essential commodities, such as food or water. But over the past few decades digital displays have become so enmeshed in our lives that they are integral to our social interactions and livelihoods from rural East Africa to the offices of Wall Street. I have met Kenyan fisherwomen trading their wares via SMS to clients based hundreds of kilometres away – an opportunity that depends on indium just as much as my need to read these words I am typing on my computer monitor.

Wonder metal

Though it was discovered 150 years ago, indium’s remarkable qualities have been harnessed only recently to create wafer-thin electrodes. It is a very soft silvery metal that can be painted onto glass because unlike other soft metals, such as mercury, it wets the glass rather than forming beads. (Another curious property of indium is that when you bend a rod of the metal, it issues a high-pitched crackling sound, known as its “cry”.)

Indium is most useful, however, when it is manufactured into indium tin oxide, or ITO. The reason you cannot see it is because when indium reacts with oxygen, it becomes transparent. This, plus its tremendous ability to conduct electricity, allows our mobile phones to be smarter, our TV flatscreens to be larger and our tablet computers to be more sleek.

As a result, the price of indium has rocketed in recent years – it went from $60 per kilogramme in 2003 to $1,000 in just three years – giving rise to a whole new indium smuggling industry, primarily out of China. And there is no let up on our demand for hi-tech displays – there were more than 1.5 billion mobile phone handsets alone sold in 2011, one of which was to me.

But the supply of indium cannot meet our voracious demands. Indium is harvested as a byproduct of zinc mining because this so-called "hitchhiker" metal exists almost entirely in trace amounts inside deposits of other ores such as zinc and lead – sometimes as little as 1 part per million. And because indium is not mined in its own right, greater demand for it won't necessarily lead to more being mined, according to Robert Ayres, a physicist and economist at INSEAD business school in France. "Most of the indium is just single atoms stuck inside rock that can never be utilised," he says.

If the most gloomy predictions for indium are true, Ayres says the only solution is to increase recycling efforts. Because of its value, the indium recycling market is already bigger than primary production.

But a single monitor screen typically contains less than 0.5 g of ITO, so recovering such a tiny amount from electronic products is expensive and energy-intensive. "I call indium a “spice metal”, because it's sprinkled into products in a way that makes it almost impossible to recover," says Armin Reller, a materials physicist at the University of Augsburg in Germany.

So what other options do we have to indium? Finding a material that is transparent, light and conducts electricity as efficiently as ITO is a big challenge, but there are some candidates. So-called non-stochiometric tin oxides, which use the far more abundant aluminium, are one option that could be incorporated fairly easily into current manufacturing set-ups. The problem is that they do not perform as well as ITO and that tin is itself running out, with reserves estimated to last another 20-40 years.

Researchers in Germany and Japan are working on a flexible polymer-based material called PEDOT, which when doped with various chemicals becomes more transparent and a better conductor. Again, the polymer relies on non-renewable oil or coal supplies.

What’s desperately needed is a sustainable alternative, and the best solution could come in the shape of a remarkable material called graphene, the subject of a recent Nobel Prize. Like pencil-lead and diamonds, graphene is yet another form of carbon, one of the most abundant elements on Earth. Graphene's carbon atoms are arranged in a flat sheet of hexagons, like chicken wire, and this structure makes it the strongest known material and can conduct electricity as well as copper. And because graphene is just one atom thick, it is almost transparent.

Graphene may be one of the most versatile materials ever discovered – with an endless list of possibilities ranging from miniaturised computer chips to high-capacity batteries (and believe it or not for making extra-strong vodka). But one of its most-desired applications is to roll it up into carbon nanotubes and use it in touchscreens, as it offers several advantages over ITO. Graphene is more stable, so it will survive better in applications where the product will be subjected to constant physical force, such as regular finger-pounding. And graphene's superior flexibility means that it can be shaped in various configurations – you could create a spherical touchscreen, for example.

So why have we not already moved from ITO to carbon? Mark Hersam, a carbon nanotubes pioneer at Northwestern University in Illinois, believes we're waiting for an industry tipping point. "There's tremendous inertia in the electronics sector because the entire industry is modelled around ITO. Big companies like Apple are wedded to the ITO manufacturing processes and will need to invest substantially to start using carbon," he says. However, as the price of indium goes up and it becomes harder to get hold of, there is likely to be a switch."

With solar cells and electronics all competing for the same rare metal, industry is already under increasing pressure to start using a different material, whether that's another metal oxide or novel carbon chicken-wire. Looking through the breathless coverage of the iPad 3 launch on my phone, one thing is for sure: our unwavering enthusiasm for touchscreen/display-screen technologies means we desperately need to find alternatives soon.

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Stem cells beat kidney rejection

Stem cells beat kidney rejection

Operating theatre
The study involved eight patients

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An injection of stem cells given alongside a kidney transplant could remove the need for a lifetime of drugs to suppress the immune system, say scientists.

Early tests of the technique at US hospitals were successful in a small number of patients.

The journal Science Translational Medicine reports how the majority no longer need anti-rejection medication.

Researchers said it could have a "major impact" on transplant science.

One of the key problems associated with organ transplantation is the risk that the body will "recognise" the new organ as a foreign invader and attack it.

To prevent this, patients take powerful drugs to suppress their immune systems, and will have to do this for life.

The drugs come at a price, preventing organ rejection but increasing the risk of high blood pressure, diabetes and serious infection.

Challenges

The study, carried out at the University of Louisville and the Northwestern Memorial Hospital in Chicago, involved eight patients.

Their transplant came from a live donor, who also underwent a procedure to draw stem cells, the building blocks of their immune system, from the blood.

The transplant recipient's body was prepared using radiotherapy and chemotherapy to suppress their own immune system.

Then the transplant went ahead, with the stem cells put into their body a couple of days later.

“Start Quote

It's almost surreal when I think about it because I feel so healthy and normal”

Lindsay Porter

The idea is that these will help generate a modified immune system that no longer attacks the organ or its new owner.

Although the patients started off with the same anti-rejection drugs, the aim was to reduce these slowly, hopefully withdrawing them completely over time.

Five out of the eight patients involved in the trial managed to do this within a year.

One of those is 47-year-old Lindsay Porter, from Chicago.

She said: "I hear about the challenges recipients have to face with their medications and it is significant.

"It's almost surreal when I think about it because I feel so healthy and normal."

Dr Joseph Leventhal, associate professor of surgery at Northwestern University Feinberg School of Medicine, said: "The preliminary results from this ongoing study are exciting and may have a major impact on organ transplantation in the future."

He said that, as well as kidney patients, the technique might improve the lives of those receiving other organs.

While stem cells from organ donors have been used before, this is the first time it has been used for "mismatched" transplants, in which donors and recipients do not have to be related and immunologically similar.

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The Raspberry Pi computer goes on general sale

The Raspberry Pi computer goes on general sale

Dr Eben Upton of the Raspberry Pi Foundation shows Rory Cellan-Jones how the computer works

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A credit-card sized computer designed to help teach children to code has gone on sale for the first time.

The Raspberry Pi is a bare-bones, low-cost computer created by volunteers mostly drawn from academia and the UK tech industry.

Sold uncased without keyboard or monitor, the Pi has drawn interest from educators and enthusiasts.

Supporters hope the machines could help reverse a lack of programming skills in the UK.

"It has been six years in the making; the number of things that had to go right for this to happen is enormous. I couldn't be more pleased," said Eben Upton of the Raspberry Pi Foundation which is based in Cambridge.

“Start Quote

That's eight weeks pocket money for me”

Peter Boughton, 12, from Cambridgeshire

Massive demand for the computer has caused the website of one supplier, Leeds-based Premier Farnell, to crash under the weight of heavy traffic.

School tools

The device's launch comes as the Department for Education considers changes to the teaching of computing in schools, with the aim of placing greater emphasis on skills like programming.

In a speech outlining those changes, Michael Gove mentioned the Pi, suggesting devices like it could play an important role in the kind of computer class the government envisages.

"Initiatives like the Raspberry Pi scheme will give children the opportunity to learn the fundamentals of programming," he said.

"This is a great example of the cutting edge of education technology happening right here in the UK."

Initially the £22 ($35) model of the Pi will be offered for sale. A cheaper £16 ($25) version will go on sale later in the year.

The machine, which runs on open-source operating system Linux, can be hooked up to a typical computer monitor - with additional ports used to attach a keyboard, mouse and other peripherals.

It also features an ethernet port, meaning the device can make use of high-speed internet connectivity.

Supporters hope the thousands-strong community of people that has grown up around the Pi will help develop additional software and suggest uses for the device.

The Pi going on general sale is likely to add to the buzz around the machine, but there are already a number of similar stripped-down computers on the market.

These include devices such as the Beagleboard and the Omnima MiniEMBWiFi.

Bottle-necks banished

The Raspberry Pi Foundation says it has already produced thousands of the machines, using a Chinese manufacturer.

“Start Quote

The real task, however, is not about getting the Raspberry Pi out to that impatient crowd of enthusiasts. What matters is the kind of reception the device gets when it arrives in schools”

It had originally hoped to produce the devices in the UK - "we want to help bootstrap the UK electronics industry" the group wrote in a blog post - but that turned out not to be possible at the right price.

But while production remains overseas, deals with two distributors, Premier Farnell and RS Components, mean that production volumes will be able to grow much faster than previously thought.

Rather than the foundation having to fund production, distributors have agreed to handle orders and deal with manufacturers paying the foundation a royalty on sales.

Mr Upton says that will help the project grow much more quickly then previously thought.

"We didn't realise how successful this was going to be," he said.

"This means we can scale to volume. Now we can concentrate on teaching people to program."

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