Thursday, March 8, 2012

Single molecule's electric charges seen in first image

Single molecule's electric charges seen in first image

Experimental and theoretical representation of charge distributions (IBM Research)
The team's first-ever charge distribution measurements (top) matched neatly with theory

Related Stories

Researchers have shown off the first images of the "charge distribution" in a single molecule, showing an intricate dance of electrons at tiny scales.

Charges on single atoms have been measured before, but capturing the dance within a complex molecule is significantly more difficult.

The pioneering measurement could shed light on a range of "charge-transfer" processes that are common in nature.

Details are reported in the journal Nature Nanotechnology.

The work comes from a group at IBM Research Zurich that specialises in examining the world at the infinitesimal scale of atoms and molecules.

The same team is responsible for the measurement of charge on single atoms, as well as the first image of a single molecule - in a sense the new work is a combination of those two views.

However, it makes use of a different technique, called Kelvin probe microscopy. It is a variant of the atomic force microscopy that allowed the first molecular image in 2009.

It requires a tiny bar just billionths of a metre across and with a sharp tip that ends in a single small molecule. This bar, or cantilever, is held at a small voltage while it is scanned across the surface of a much larger, X-shaped molecule, naphthalocyanine.

As the charged tip encounters charges within the naphthalocyanine, the cantilever begins wagging in a way that shows up precisely where the electrons are.

The trick of naphthalocyanine, though, is that by applying a voltage to the molecule directly, two hydrogen atoms at its centre swap places, and the electrons reshuffle to opposite arms of the "X".

With the team's technique, they were able to observe this change in charge distribution.

In combination with more established techniques, the approach will shed light on the nanoscale world that is promising not only for fundamental science, but also for future applications in which electric behaviour at such scales will be exploited.

"It will now be possible to investigate at the single-molecule level how charge is redistributed when individual chemical bonds are formed between atoms and molecules on surfaces," said lead author of the research Fabian Mohn.

"This is essential as we seek to build atomic and molecular scale devices."

Source

Wikileaks suspect Bradley Manning enters no plea

Wikileaks suspect Bradley Manning enters no plea

Pte Bradley Manning appearing for his pretrial hearing at Fort Meade, Maryland, 22 December 2011 Bradley Manning is accused of leaking 700,000 files to Wikileaks

Related Stories

The US Army private accused of leaking classified documents to Wikileaks has chosen not to enter a plea at the start of his court martial.

The 24-year-old was read the 22 charges against him at a hearing at Fort Meade, Maryland.

If found guilty of leaking and "aiding the enemy" he could face a life term.

Pte Manning, who was first arrested in May 2010, appeared for a pre-trial hearing in December, following which a court martial was recommended.

Thursday's arraignment hearing offered the defendant his first opportunity to state his case personally.

As well as deferring a plea, he also passed on the opportunity to decide whether to be tried by a military jury or a single judge.

When asked if he understood his rights to counsel, Pte Manning told the judge: "Yes, your honour."

He spoke several times, giving brief replies to questions from lawyers and the judge.

Another procedural hearing has been set for 15 March.

Breaches

Defence lawyer David Coombs has asked that the court martial begin in June, but prosecutors want an August start date.

Mr Coombs says his client will have spent more than 800 days in jail by August.

During his pre-trial hearing in December, defence lawyers argued that Pte Manning was a troubled young man with gender identity issues.

They suggested he should not have been sent to Iraq, where he served as an intelligence analyst with access to classified material.

Pte Manning is alleged to have been the source of a series of high-profile stories that saw Wikileaks rise to global fame.

After a video showing US troops firing on Iraqis from a helicopter came caches of documents from both the Iraq and Afghan wars, and a huge haul of classified state department cables.

Source

Google and Facebook in White House web privacy sights

Google and Facebook in White House web privacy sights

File photo of Google logo 17 January 2008
The Center for Digital Democracy filed a complaint this week over Google's privacy policy

Related Stories

The White House has called on internet firms to develop stronger privacy protections for consumers.

The move comes amid worries that browsing information is being tracked and given to advertisers.

State attorneys in 36 states recently sent a letter of concern over Google's plan to share personal information across its products.

As part of the announcement, the firms' ad networks said they would support a "Do Not Track" browser option.

The US has advocated since 2010 for "Do Not Track", a one-click option to prevent information gathered while web browsing being shared with third parties.

'Bill of rights'

In a statement, President Barack Obama outlined a "consumer privacy bill of rights".

The White House said internet users should have the right to limit the context in which information was collected, should be allowed to correct information and should have the right to transparency in privacy policies.

Companies like Google and Facebook have signed on to develop guidelines based on the "bill of rights", enforceable by the US Federal Trade Commission (FTC).

"American consumers can't wait any longer for clear rules of the road that ensure their personal information is safe online," Mr Obama said.

"As the internet evolves, consumer trust is essential for the continued growth of the digital economy."

Privacy complaints

Privacy advocates will be involved with the development of the new guidelines, but some remain concerned about the firms' ability to self-regulate.

"The real question is how much influence companies like Google, Microsoft, Yahoo and Facebook will have in their inevitable attempt to water down the rules that are implemented and render them essentially meaningless," John Simpson, who works on privacy issues for Consumer Watchdog, told the New York Times.

Marc Rotenberg, the executive director of the Electronic Privacy Information Center, called the announcement "the clearest articulation of the right to privacy by a US president in history".

However, he told Reuters news agency there were "real concerns about implementation and enforcement".

The FTC has taken previous action against Facebook and Google over privacy complaints, both of which were settled in 2011.

While US legislators have argued that online tracking should be curtailed, little has been done.

Any guidelines developed by US officials in concert with internet firms would be enforceable by the FTC once agreed on, but would not necessarily apply to companies that did not sign on.

Source

US freezes Japan gangsters' financial assets

US freezes Japan gangsters' financial assets

Kenichi Shinoda gets into a car after arriving at the train station in Kobe, western Japan on April 9, 2011
The US Treasury is targeting Japan's Kenichi Shinoda

Related Stories

The US has targeted organised crime by freezing the financial assets of two groups - Japan's Yamaguchi-gumi yakuza group and the Brothers' Circle.

The Department of the Treasury said it was also freezing the assets of key members, including Yamaguchi-gumi leader Kenichi Shinoda.

This is the first time measures have been imposed following a presidential executive order last year.

No details were given on the value of the frozen assets.

President Barack Obama issued the executive order in 2011 to "target and disrupt significant transnational criminal organisations".

Under the order members of crime organisations could be identified, their assets within US jurisdiction frozen and their supporters prohibited from doing any transactions in the US.

"They use our financial system, they use our commercial system to both penetrate the markets, to disrupt the markets and to make use of their illicit proceeds," said David S. Cohen, Treasury under-secretary for terrorism and financial intelligence, on Thursday.

The Treasury also listed nine individuals - two from the Yamaguchi-gumi and seven from the Brothers' Circle - as being subject to financial sanctions.

The Brothers' Circle, described as a "muti-ethnic criminal group", operates in at least four continents.

Source

Syria unrest: Opposition seeks arms pledge

Syria unrest: Opposition seeks arms pledge

Unverified footage shows an apparent attack by opposition fighters on one of President Assad's tanks, as Bridget Kendall reports from Tunis

The main Syrian opposition group has asked for rebel fighters to be allowed to import weapons.

The plea came at a major international "Friends of Syria" conference being held in Tunisia to seek a breakthrough in the increasingly bitter conflict.

A declaration is expected later, calling on Syrian forces to declare a ceasefire and allow humanitarian access to the worst-hit areas.

Syrian state TV said the conference was a meeting of "symbols of colonialism".

Those attending, it said, were "historic enemies of the Arabs".

The US, Europe and Arab countries plan to challenge President Bashar al-Assad to provide humanitarian access within days, with the threat of fresh sanctions if he does not comply.

Around 70 nations, including the US, UK, France and Turkey, are attending the conference, organised by the Arab League.

“Start Quote

The Friends of Syria should not constrain individual countries from aiding the Syrian opposition by means of military advisers, training and provision of arms to defend themselves”

Syrian National Council

But Russia and China, key allies of Syria which have blocked UN resolutions again Damascus, are not there.

A group of pro-Assad protesters forced their way into the grounds of the hotel where the conference is being held, Reuters news agency reported, but tight security prevented them getting into the building.

'Offensive measures'

The leading opposition group, the Syrian National Council, said countries should be allowed to supply arms if Damascus refused to bow to outside pressure.

Analysis

Syrian opposition groups point to the disparity of force in this conflict - their Kalashnikovs against Syrian government artillery - and are calling for arms supplies to help them defend themselves against President Assad's forces.

For now, at least, Western governments believe that arms supplies would only further militarise the conflict, making a bad situation worse. But if the bloodshed continues then the pressure - at least covertly - to arm the opposition will grow.

I asked UK Foreign Secretary William Hague as he arrived at the conference to confront this question square on. Had the time come - I asked - to arm the Syrian opposition fighters? There was, he replied, a European Union arms embargo in place against Syria and Britain, he stressed, would abide by it.

There was of course an arms embargo in force in Libya but that didn't prevent Qatar, France and others supplying weaponry to Col Gaddafi's opponents. Even the US seems to be shifting its position slightly - Secretary of State Hillary Clinton implying that one way or another the opposition would get arms from somewhere. If the fighting continues this is going to become an ever more pressing question.

"If the regime fails to accept the terms of the political initiative outlined by the Arab League and end violence against citizens, the Friends of Syria should not constrain individual countries from aiding the Syrian opposition by means of military advisers, training and provision of arms to defend themselves."

The conference endorsed the council as a "credible" voice of opposition, while making clear it did not exclude other groups - thereby stopping short of declaring it a plausible government-in-waiting.

At least one other opposition group, the National Co-ordination Committee for Democratic Change (NCCDC), is boycotting the meeting, saying it excludes some voices and leaves open the idea of military intervention, AFP news agency reports.

Activists say more than 7,000 people have died in the 11-month uprising - more than 90 on Thursday alone - and concern is growing over the humanitarian situation, particularly in the besieged city of Homs.

The International Committee of the Red Cross (ICRC) appealed this week for a pause in fighting to allow aid to be taken in, but said it had received no response from Damascus.

The ICRC said it was becoming "more and more concerned over humanitarian needs that are increasing by the hour".

Spokesman Hicham Hassan told Reuters news agency: "It is crucial that our initiative is met with a positive and concrete reaction urgently."

Journalists' appeal

US Secretary of State Hillary Clinton told the conference the Syrian government had "ignored every warning, squandered every opportunity and broken every agreement".

"If the Assad regime refuses to allow this life-saving aid to reach civilians, it will have ever-more blood on its hands,'' she said in opening remarks.

Edith Bouvier: "I need an urgent operation"

UK Foreign Secretary William Hague said "terrible crimes" were being committed in Homs.

"I think we have seen enough in the last few weeks to know that the Assad regime will go down in history as a criminal regime," he said.

French Foreign Minister Alain Juppe said the conference needed to exert the maximum pressure on the Syrian government and also on Russia, but insisted there was no military option on the table and France could not envisage such an option without an international mandate.

The BBC's Jonathan Marcus in Tunis says the conference is a means of getting around Russia and China, which have faced Western and Arab criticism for vetoing a UN Security Council resolution condemning Syria and Mr Assad.

Moscow and Beijing have said they want to see an end to the violence but that such action amounts to forced regime change.

On the eve of the conference, the UN and Arab League appointed Kofi Annan as their envoy to Syria.

Mr Annan, a former UN secretary general who has acted as a diplomatic troubleshooter in several long-running conflicts, said he hoped to "help bring an end to the violence and human rights abuses, and promote a peaceful solution to the Syrian crisis".

Diplomats attending the conference say the UN will call for preparations to start an Arab/UN peacekeeping force for Syria, to assist with the political transition after the violence ends, the BBC's Kim Ghattas reports from Tunis.

The civilian police force would be deployed only in a "permissive" environment, under Chapter 6 of the UN charter.

Diplomats said the efforts were designed to show a political transition was inevitable and that President Assad's rule was coming to an end.

The conference comes two days after two journalists - American Sunday Times reporter Marie Colvin and French photographer Remi Ochlik - died during shelling in Homs.

Two journalists wounded in the same attack have made internet appeals for medical help. Frenchwoman Edith Bouvier is being treated by Syrian medics but needs surgery which they are unable to perform. Paul Conroy, who is British, also asked for outside help to bring him to safety.

Source

~~~~~~~~~~~~

Commentary

What happened to peaceful opposition like we were taught in America?

How can anyone support this type of aggressive activism?

It involves the deaths of hundreds of people; completely unjust.

What can political donors learn from history?

What can political donors learn from history?

Sheldon Adelson Adelson could probably finance an entire presidential campaign on his own, Forbes Magazine says

A billionaire Las Vegas casino magnate has said he might donate $100m (£64m) to support Republican Newt Gingrich's presidential campaign. He joins history's long list of great - and ignominious - political money men.

Sheldon Adelson, who is worth an estimated $25bn, is almost single-handedly responsible for keeping Mr Gingrich's bid for the Republican nomination afloat, analysts say.

He and his wife have already donated $10m to a nominally independent political fund that has bought adverts for the former House speaker's campaign.

"What scares me is the continuation of the socialist-style economy we've been experiencing for almost four years," Mr Adelson told Forbes Magazine.

"That scares me because the redistribution of wealth is the path to more socialism, and to more of the government controlling people's lives."

Mr Adelson's big contributions place him among a new generation of US political money men freed to donate millions by recent Supreme Court decisions that overturned campaign finance restrictions.

But he is part of a long tradition - stretching back into antiquity - of wealthy men who used their cash to buy political influence.

Here are some lessons he could heed:

Lesson 1: Patronage can yield profits

Crassus Crassus, seated, enabled Caesar's rise by backing his debts and funding his campaign for consul

Known to historian Plutarch as "the richest of the Romans", Marcus Crassus got even richer by staking Julius Caesar's military career and his later election as Roman consul.

"We never would have heard of Caesar without Crassus," says Philip Freeman, chairman of the classics department at Luther College in the US state of Iowa and author of a recent biography of Caesar.

Born in a household of relatively modest means, Crassus aligned himself with Roman dictator Sulla and grew rich by taking property Sulla had expropriated from his own political enemies.

He made "the public calamities his greatest source of revenue", Plutarch wrote, and also made lots of money as a contract tax collector.

In 61BC, Caesar was named to a military post in Spain, but his creditors sought to prevent him from leaving Rome.

Crassus guaranteed his debts - to the sum of about $23m (£14.6m) in 2012 figures, by Prof Freeman's calculation.

Two years later, Caesar ran for election as consul, the highest political office in the Roman republic. Crassus funded his campaign, which depended on officially condemned but widespread vote-buying, Freeman says.

In return, Caesar pushed through legislation giving the contract tax collectors a break in the amount of money they had to return to the central government.

"It's like if Mr Gingrich got to be president and passed a bill making casinos tax exempt - for his benefactor back in Las Vegas," says Prof Freeman.

"It was a great financial play for Crassus purely in monetary terms."

Lesson 2: Have an exit strategy

Sir William de la Pole of Hull was a 14th-Century wine importer, wool merchant and financier who lent staggering sums of money to King Edward III to finance his lavish lifestyle and his wars in France and Scotland.

"There's no doubt that Pole did acquire a great deal of wealth, and wealth brought him social status," says Jonathan Sumption, a historian and jurist who has written three volumes about The Hundred Years War.

"His sons went on to become Earls of Suffolk, noblemen, which nobody would have accused William of being. You couldn't do much better than that. This was simply the normal way in which money was converted into status."

Pole's involvement with the crown began in earnest in 1327, when he lent Edward III £2,001 (about £1.4m in today's money, according to Measuringworth.com, a calculator devised by economists at the University of Illinois at Chicago) to hire mercenaries to fight the Scots.

In 1336-1337, Edward III sought to exploit the wool industry to finance the start of the Hundred Years War with France.

Pole organised other wool growers into the Wool Company, in effect purchasing from Edward III the right to export wool on privileged terms, Mr Sumption says.

Between June 1338 and October 1339, he lent the crown £111,000 (more than £86m in 2012 figures).

For Pole himself, the story did not end well.

Edward III grew resentful at his dependence on Pole and imprisoned him for two years. He was released because the king again needed his help raising money.

Edward defaulted on his debts because the wars cost more than his tax revenue, Mr Sumption says, and Pole and his partners went bust.

"Lending to the king was a mug's game," Mr Sumption says. "The problem was that if you didn't you were likely to be ruined anyway."

Lesson 3: The stakes are high

Thomas Seymour When Seymour's political intrigue failed, he lost more than his shirt

When Edward VI ascended to the throne in 1547 at the age nine, members of the Tudor court began jockeying for position and influence.

Two of the top intriguers were his uncles Edward and Thomas Seymour.

Edward Seymour managed to have himself declared Lord Protector of the Realm, Governor of the King's Person and later Duke of Somerset, making him the most powerful man in the court.

But Thomas Seymour, who had been well placed under Henry VII, found himself increasingly frozen out.

Among his several schemes to gain influence over the boy king, Seymour began supplying him with pocket money, telling him "you are a beggarly king, you have no money to play or to give".

Edward VI, who had reportedly complained to Seymour that Somerset "deals very hardly with me and keeps me so straight that I cannot have money at my will", wanted the cash to pay for musicians in his court and to reward his personal servants, says John Cooper, a lecturer in early modern history at the University of York.

Seymour gave the king £188 (about £70,400 in today's value), funnelled in part through Edward's personal servants and his tutor.

"It's a political gamble that fails very dramatically," Mr Cooper says.

When Somerset found out about that and other intrigues (Seymour also flirted with the teenaged Princess Elizabeth, whom he may have hoped to marry), he had him arrested and charged with treason.

He was beheaded at the Tower of London.

On hearing of his execution, Elizabeth said: "This day died a man with much wit, and very little judgment."

Lesson 4: Be prepared to lose big

Among the liberals incensed about the Vietnam war in the late 1960s and early 1970s was Stewart Mott, the black-sheep son of a wealthy Detroit car manufacturing family.

Mott, who described himself as an "avant-garde philanthropist", donated more than $200,000 to the 1968 presidential campaign of Eugene McCarthy, and about $400,000 in 1972 to George McGovern, the Democratic challenger to President Richard Nixon, according to Mr Corrado, the campaign finance expert.

His big contributions in part led Congress to enact strict limits on direct contributions to political campaigns that remain in effect to this day (though giving to independent committees are unlimited).

"He identified with their politics, and whatever one means by progressive, he was it," says Victor Navasky, professor of journalism at Columbia University.

"He cared about them, and he hoped to help them attain the White House."

Despite Mott's seed money, Mr McGovern suffered one of the greatest political defeats in American history, winning only the state of Massachusetts and Washington DC.

Mott's support for liberal candidates earned him a spot on Nixon's infamous enemies list. Nixon aide Chuck Colson listed him as "nothing but big money for radic-lib candidates".

Source

What has happened to Nasa's missing Moon rocks?

What has happened to Nasa's missing Moon rocks?

moon rock practice 13 Oct, 1969

The US space agency Nasa recently announced that many of the Moon rocks brought back to Earth from two Apollo space missions have gone missing. They were given as gifts to the nations of the world. So what happened to them?

Towards the end of the Apollo 17 mission on 13 December 1972, Eugene Cernan and Harrison Schmitt - the last men to have set foot on the Moon - picked up a rock.

Cernan announced: "We'd like to share a piece of this rock with so many of the countries throughout the world."

His wish was fulfilled.

President Richard Nixon ordered that the brick-sized rock be broken up into fragments and sent to 135 foreign heads of state and the 50 US states.

Each "goodwill Moon rock" was encased in a lucite ball and mounted on a wooden plaque with the recipient nations' flag attached.

Moon rock infographic

Moon rock collected during the Apollo 11 mission in 1969 was also distributed to the same nations and US states.

There were 370 pieces gathered for this purpose from the two missions. Two hundred and seventy were given to nations of the world and 100 to the 50 US states.

But 184 of these are lost, stolen or unaccounted for - 160 around the world and 24 in the US.

The rocks were distributed to countries ranging from Afghanistan to Trinidad and Tobago.

Joseph Gutheinz Joseph Gutheinz's search for the missing Moon rocks began in 1998

"Gaddafi's government was given two Moon rocks - they're missing. Romania is missing its Apollo 17 goodwill Moon rock," says Joseph Gutheinz Jr, the Texas-based lawyer and former Nasa agent, who has become known as the "Moon rock hunter".

His obsession began in 1998 when - still at Nasa - he set up an undercover sting operation called Operation Lunar Eclipse.

He placed an advert entitled "Moon Rocks Wanted" in USA Today, to entice con-artists selling bogus Moon rocks to approach him.

"What I did not anticipate was that a person with the real thing, the Honduras goodwill Moon rock, would call me," he says.

The rock - which weighed 1.142g - was offered to Gutheinz for $5m (£3m).

He did not pay the money, but says the asking price was reasonable.

These valuable rocks are not being protected as well as they could be, he says, and both Nasa and the recipient nations have done a poor job of entering them into an inventory system.

He says the only authorised sale of lunar material that he is aware of was in 1993, when the Russian government sold material gathered from the Soviet Union's Luna 16 mission at Sotheby's auction house in New York.

From lunar landscape to Dublin dump

Dr Ian Elliott worked at the Dunsink Observatory in Dublin when it was destroyed by fire on 3 October 1977.

I heard about the fire on the morning news. I can tell you, that was a bit of a shock.

My main concern was with the disruption to the work of the observatory. It was only afterwards that we realised that the bit of Apollo 11 Moon rock could not be found.

It was gathered up with all of the other debris and dumped in the municipal dump which was conveniently just across the road.

It is probably the only municipal dump in the world that has got a bit of Moon rock.

If we'd had any perception of the rock's value, perhaps all of the debris would have been sifted by archaeologists and it might have been found.

I am amazed that anyone puts a value of $5m on it, though there are a lot of mad people with money around so they might just pay that.

It is a very big dump, I am afraid. It is worse than a needle in a haystack - you would never find it.

An anonymous private collector bought 0.2g of lunar dust for $442,500 (£280,000).

With potential prices in this range, it is no surprise there is a lucrative black market in moon rocks, both real and fake.

Mr Gutheinz says a woman in California allegedly tried to sell a Moon rock online, and that attempts to sell Spain's and Cyprus's moon rocks have been well documented.

"I once offered $10,000 for the recovery of Malta's stolen Apollo 17 goodwill Moon rock but it still hasn't been recovered," he says.

"I know for certain that this was an amateur thief as he only took the rocks, and not the self-authenticating plaque."

Some Moon rocks have gone astray at times of revolution or political transition. The US national archives show that a rock was presented to the late Romanian dictator, Nicolae Ceausescu, but Gutheinz believes it was sold after his execution.

Then there is the mysterious tale of how - after a fire at an observatory in Dublin - Ireland's Apollo 11 Moon rock ended up lying in a rubbish dump, after apparently being thrown out with the rest of the debris.

"It's still there under a couple of tonnes of trash. That could definitely be worth over $5m (£3.1m). I'll tell you where it's at. It's in the Finglas landfill dump in Dublin," Gutheinz says.

Because of the scale of the task he has challenged his students at the University of Phoenix and Alvin Community College in Texas - where he teaches criminal justice - to help find the missing rocks.

So far, they have helped to track down 77, including those that were given to the governors of the US states of Colorado, Missouri and West Virginia.

Moon rock in a plaque The Honduras Moon rock was recovered in a sting operation

Dr Carle Pieters, a planetary geologist at Brown University, Rhode Island, says the knowledge gained from these tiny rocks is priceless.

"I am continually awed when I work with four-billion-year-old lunar samples. They are beautiful and don't have ugly weathering products often seen in Earth rocks.

"The lunar rocks retain a record of events in the early solar system that we cannot obtain elsewhere."

While Joseph Gutheinz has compared them to works of art, not everyone is so enthusiastic about them. London-based art writer and curator, Francesca Gavin, describes them as "ugly little things", although she is not opposed to the idea of seeing one in an art gallery.

"Moon rocks could be seen as artworks - relating in particular to the Chinese tradition of the Philosopher Stones as naturally occurring artworks reflecting the universe in microcosmic form," she says.

Gavin does not think the rocks are worth $5m (£3.1m), however, and questions the way they are mounted as goodwill gifts.

"The brown plaque, text and flag? It's pretty uneasy on the eyes."

Gutheinz concedes he will never be able to recover all of the missing Moon rocks - many are now in private collections - but says there are some he particularly wants back.

"Definitely the Malta Moon rock. I'd really like to see that back, and the Romanian rock. If I go to Europe, I will hunt that one down. I have a few ideas as to how I'll do that.

"And I love the story about the Ireland Moon rock - that pot of gold under a dump."

Source

Pancreatic cancer: Trial drug MRK003 shows promise

Pancreatic cancer: Trial drug MRK003 shows promise

Pancreatic cancer cell
Doctors want to improve the prognosis of this aggressive cancer

Related Stories

Scientists say they may have found a new weapon against pancreatic cancer after promising early trial results of an experimental drug combination.

Giving the chemotherapy agent gemcitabine with an experimental drug called MRK003 sets off a chain of events that ultimately kills cancer cells, studies in mice show.

Patients are now testing the treatment to see if it will work for them.

The Cancer Research UK-funded trials are being carried out in Cambridge.

Father-of-two Richard Griffiths, 41, from Coventry, has been on the trial since being diagnosed with pancreatic cancer in May 2011.

"After six cycles of treatment, a scan showed the tumours had reduced and so I have continued with the treatment," he said.

"The trial gives you hope - I really feel I can do this with the science behind me."

Aggressive cancer

Cancer Research UK says it is prioritising research into pancreatic cancer because the survival rate still remains dismally low.

About 8,000 people in the UK are diagnosed with pancreatic cancer each year, and the disease is the fifth most common cause of cancer death in the UK.

Survival rates are very low in relation to other cancers, and the length of time between diagnosis and death is typically short, usually less than six months.

The most recent data for England show that about 16% of patients survive the disease beyond 12 months after diagnosis - prompting the need for new treatments.

Professor Duncan Jodrell, who is leading the trials at the University of Cambridge, said: "We're delighted that the results of this important research are now being evaluated in a clinical trial, to test whether this might be a new treatment approach for patients with pancreatic cancer, although it will be some time before we're able to say how successful this will be in patients."

In total, about 60 patients with advanced pancreatic cancer will be recruited for the first Phase I/II clinical trial.

Source

The cult of the hyperpolyglot

The cult of the hyperpolyglot

Alex Rawlings demonstrates his 11 languages

Many people want to speak a second language, but for some people two can never be enough. Welcome to the world of the hyperpolyglot.

Ray Gillon speaks 18 languages. To be precise, he only speaks eight fluently. His grasp on the other 10 is merely conversational.

Throw anything at him in Portuguese, Thai, Turkish, Russian, Polish, Dutch, Danish, Norwegian, Bulgarian or Mandarin and he will banter back.

In the UK, where there has been a growing anxiety over the failure to learn additional languages, Gillon might seem to be a bit of an anomaly. More and more children have been giving up languages since the last government made learning foreign languages optional in England from the age of 14.

Publisher HarperCollins has been searching for the UK's most multilingual student, and has discovered a 20-year-old Oxford University undergraduate who can speak 11 languages. And a new book, Babel No More: The Search for the World's Most Extraordinary Language Learners, by Michael Erard, suggests Gillon is among a set of people who are learning languages for fun.

Ray Gillon Ray Gillon says he sees etymology as a sport and he enjoys looking up the origins of words

So what makes some people learn language after language?

For self-taught polyglot Gillon, 54, his love affair with language started by accident. He says he first learned French and Latin at the age of 11, and later studied French and German as elective courses while studying for his electronic engineering degree.

"But it wasn't until I got my first job, and was sent to live in the south of France, that I had any real enthusiasm for languages," he says.

It was during this chapter of his life, while designing audio visual systems for a cruise liner, that Gillon was introduced to Italian through colleagues.

What's that you're saying?

Beatles promote multi-language version of their song All You Need Is Love
  • Up to 7,000 different languages are estimated to be spoken around the world
  • Mandarin Chinese, English, Spanish, Hindi, Arabic, Bengali, Russian, Portuguese, Japanese, German and French are world's most widely spoken languages, according to UNESCO
  • Languages are grouped into families that share a common ancestry
  • English is related to German and Dutch, and all are part of Indo-European family of languages
  • Also includes French, Spanish and Italian, which come from Latin
  • 2,200 of the world's languages can be found in Asia, while Europe has 260

Source: BBC Languages

"I went to Italy for a weekend, and fell in love with the language. I bought books and started teaching myself. By the end of my three years in France, I was fluent in both languages," he says.

Gillon's next job took him round the world, and pretty soon he was up to speed on German, Spanish, Polish, Portuguese and Swedish.

He says he used half a dozen languages every day for 10 years and his current job, which involves supervising foreign language versioning of Hollywood movies, means he has to stay on top of his skills.

"I have a massive foreign language book library, so I regularly keep up to date, revising grammar, reading newspapers, watching satellite television.

"My much better half is also Swedish and speaks six languages - we probably speak them all every day," he says.

According to author and linguistics expert Erard, there are not many hyperpolyglots like Gillon in the world. He has identified 11 languages as a significant watershed. Those who speak more than this are very rare.

But he says it is difficult to define hyperpolyglots and polyglots because essentially it has to be about speaking and knowing rather than reading and writing. In some cases literacy is not possible, or a language does not have an alphabet.

He says the question of "how much a language weighs" is also significant in determining how unusual a linguist is.

Rise of the polyglots

"Most people say it's easier to pick up languages when you're younger," says David Green, of University College London, who specialises in bilingualism.

"But people can learn languages at any point in their lives. Being immersed in a language is important. Personality is a contributing factor too - not being able to tolerate feeling foolish from making inevitable errors will make learning a new language a difficult process.

"Polyglots are definitely on the rise worldwide predominantly because of migration. In 10 years' time, it is estimated that 50% of America will be Spanish-speaking. Many of these people will speak both English and Spanish."

"If the languages are English, French, Mandarin, Japanese, Hindi and Russian - that would be more significant from a learner's perspective than 11 Romance languages such as Italian, French and Spanish," he says.

People who are gifted linguists also often have to make the choice between getting very highly developed skills in a smaller number of languages, or focusing on one aspect like the oral language, he says.

For language-lover Matt Withers, 32, who speaks German, Portuguese, Luxembourgish, French and Welsh, it is not his vocation, but a fascination with language and the world that fuels his hobby.

But rather than relying solely on books, he also signed up to a series of courses.

"When I lived in Germany, I shared a house with three Brazilians, so I did an evening course in Portuguese to converse with them - it was interesting trying to learn Portuguese through the medium of German," he laughs.

Which words come easily?

Road signs in English and Polish
  • Usually easier when second language is close to learner's native tongue in terms of vocabulary, sounds or sentence structure
  • So Polish speakers find it easier to learn Slavic languages like Czech rather than Asian ones
  • And Japanese speakers will find it easier to learn Mandarin than Polish
  • Easiest language for native English speakers to learn is said to be Dutch
  • Five most difficult languages for native English speakers are Arabic, Cantonese, Mandarin, Japanese and Korean

Source: BBC Languages

"For the past few years, I've been living in Wales - I share an office with predominantly native Welsh speakers, so I've been learning Welsh."

Withers thinks that fluency in one language allows people to accumulate others more easily.

"Most monoglots in this country aren't really able to explain English in terms such as the perfect past tense and past tense. When you learn about cases and tenses and grammatical formations, I think the tool box is there for other languages," he says.

But he concedes it is not always the case, "as Welsh isn't like any other major European language, in terms of the way it is constructed, and is incredibly different".

So what enables hyperpolyglots to seemingly pick up a new language at the push of a button?

Erard says it is hard to explain, but whatever an individual's biographical reasons are, he believes there is something that distinguishes hyperpolyglots neurologically.

"They have a neurological hardware that responds to the world, that's fed by the world, that is suited to a pattern that is recognition-heavy, sound-heavy and memory-heavy - that is very structured, and also very sociable.

Manuel from Fawlty Towers Manuel probably spoke three languages - Basil Fawlty just the one

"They have an ability to switch between languages very easily, and that involves cognitive skills which are often heritable," he adds.

But Gillon says he has no idea what the secret to his success is.

He says some "blocks" - Germanic, Slavic, Latin - make it "easier to go with the flow, and language becomes intuitive". He agrees that by the third or fourth language, it also gets easier to assimilate vocabulary and grammar much more quickly.

"Etymology is a sport for me. I enjoy looking up the origin of words and seeing which particular invasion was responsible for bringing that word into our vocabulary. I am immersed in it for my work and it will continue to intrigue me for every day of my life."

But he concludes: "I can't explain it - if I could, I would bottle and sell it."

Source

Thursday, February 23, 2012

Dolphins deserve same rights as humans, say scientists

Dolphins deserve same rights as humans, say scientists

Two dolphins at a zoo in Duisburg, Germany
Recognising the rights of dolphins would end whaling and their captivity

Related Stories

Dolphins should be treated as non-human "persons", with their rights to life and liberty respected, scientists meeting in Canada have been told.

Experts in philosophy, conservation and animal behaviour want support for a Declaration of Rights for Cetaceans.

They believe dolphins and whales are sufficiently intelligent to justify the same ethical considerations as humans.

Recognising their rights would mean an end to whaling and their captivity, or their use in entertainment.

“Start Quote

Science has shown that individuality - consciousness, self-awareness - is no longer a unique human property. That poses all kinds of challenges.”

Ethics Professor Tom White Loyola Marymount University of Los Angeles

The move was made at the annual meeting of the American Association for the Advancement of Science (AAAS) in Vancouver, Canada, the world's biggest science conference.

It is based on years of research that has shown dolphins and whales have large, complex brains and a human-like level of self-awareness.

This has led the experts to conclude that although non-human, dolphins and whales are "people" in a philosophical sense, which has far-reaching implications.

'Self-aware'

Ethics expert Prof Tom White, from Loyola Marymount University, Los Angeles, author of In Defence of Dolphins: The New Moral Frontier, said dolphins were "non-human persons".

"A person needs to be an individual. If individuals count, then the deliberate killing of individuals of this sort is ethically the equivalent of deliberately killing a human being.

Intelligent cetacean behaviour

A baby bottle-nose dolphin with her mother, in a Tokyo aquarium
  • A member of a group of orcas, or killer whales, in Patagonia had a damaged jaw and could not feed. The elderly whale was fed and kept alive by its companions.
  • Dolphins taking part in an experiment had to press one of two levers to distinguish between sounds, some of which were very similar. By pressing a third lever, they were able to tell the researchers they wanted to "pass" on a particular test because it was too hard. "When you place dolphins in a situation like that they respond in exactly the same way humans do," said Dr Lori Marino. "They are accessing their own minds and thinking their own thoughts."
  • A number of captive dolphins were rewarded with fish in return for tidying up their tank. One of them ripped up a large paper bag, hid away the pieces, and presented them one at a time to get multiple rewards.
  • In Iceland, killer whales and fishermen have been known to work together. The whales show the fishermen where to lay their nets, and in return are allowed to feed on part of the catch. Then they lead the fleet to the next fishing ground.

"We're saying the science has shown that individuality - consciousness, self-awareness - is no longer a unique human property. That poses all kinds of challenges."

“Start Quote

They can look in a mirror and say, 'Hey, that's me'”

Dr Lori Marino Psychologist

The declaration, originally agreed in May 2010, contains the statements "every individual cetacean has the right to life", "no cetacean should be held in captivity or servitude, be subject to cruel treatment, or be removed from their natural environment", and "no cetacean is the property of any state, corporation, human group or individual".

It adds: "The rights, freedoms and norms set forth in this declaration should be protected under international and domestic law."

Psychologist Dr Lori Marino, from Emory University in Atlanta, told how scientific advances had changed the view of the cetacean brain.

She said: "We went from seeing the dolphin/whale brain as being a giant amorphous blob that doesn't carry a lot of intelligence and complexity to not only being an enormous brain but an enormous brain with an enormous amount of complexity, and a complexity that rivals our own."

Dolphins had a sense of self which could be tested by the way they recognise themselves in mirrors, she added.

"When you get up in the morning and look in the mirror and know that's you, you have a sense of 'you'," said Dr Marino.

"They have a similar sense. They can look in a mirror and say, 'Hey, that's me'."

Source